Protein Alignment PITX2 and OdsH

DIOPT Version :10

• Sequence 1: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Sequence 2: NP_523389.3
• Gene: OdsH / 32758
• FlyBaseID: FBgn0026058
• Length: 382
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 89/346 - (25%)
• Similarity: 137/346 - (39%)
• Gaps: 102/346 - (29%)

Human    20 SAVSSSSCHHPQPLAM---ASVLAPG--------QPRSLD-------SSKHRLEVHTISDT---- 62
            |..:|||.:..:.:|:   |.|.|..        |.|.|:       .|:.|:::.::|.|
  Fly    62 SVTNSSSVYMIRQMALIQQARVAAAAVAMQQQQQQQRDLNRELGMDPHSEQRIKLDSVSPTHNIH 126

Human    63 --SSPEAAEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEI 125
              ||....:...|.:|.:.::|..|.::..::||.||:|.|.||:|||..||.:.|||:..||.:
  Fly   127 AGSSRGIKQDPLSDEGADSNLGQNDCTESSKKRRGRTNFNSWQLRELERVFQGSHYPDIFMREAL 191

Human   126 AVWTNLTEARVRVWFKNRRAKWRKRE----------RNQQAELCKNGFGP--------------- 165
            |...:|.|.|:.|||:||||||||:|          .|...:.|.....|
  Fly   192 ATKLDLMEGRIAVWFQNRRAKWRKQEHTKKGPGRPAHNAHPQSCSGDPIPLSELRARELAQRSKR 256

Human   166 ------------QFNGLMQPYDDMYP---------GYSYNNWAAKGLTSASLSTKSFPFFNSMNV 209
                        |..||...|..:..         |...|||         |....   ::.:::
  Fly   257 MKKAIDRQAKKLQDKGLEVDYARLEAEYLAAHQENGVDENNW---------LDDDG---YDDLHI 309

Human   210 NPLSSQSMFSPPNSISSMSMSSSMVPSAV--TGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYA 272
            :.:..:     |..::..|:..|...|..  |....|.|:|    |::   .|...|.||    .
  Fly   310 DVVGVE-----PEYVTGDSLDHSFCSSRTYQTKSTSSELDS----NDM---GLQGRVETP----P 358

Human   273 PPTPPYVYRDTCNS--SLASL 291
            ||.||...:...||  |:.||
  Fly   359 PPQPPMQNKTLYNSPFSIESL 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	31/55 (56%)
		OAR	282..299	CDD:461067	5/12 (42%)
OdsH	NP_523389.3	Homeodomain	159..215	CDD:459649	31/55 (56%)