Protein Alignment PITX2 and oc

DIOPT Version :10

• Sequence 1: NP_000316.2
• Gene: PITX2 / 5308
• HGNCID: 9005
• Length: 324
• Species: Homo sapiens
• Sequence 2: NP_001356934.1
• Gene: oc / 31802
• FlyBaseID: FBgn0004102
• Length: 664
• Species: Drosophila melanogaster
• Alignment Length: 347
• Identity: 91/347 - (26%)
• Similarity: 124/347 - (35%)
• Gaps: 111/347 - (31%)

Human    29 HPQPLAMASVLAPGQPRSLDSSKHRLEVHTISDTSSP---EAAEKDKSQQGKNEDVGAEDPSKKK 90
            ||........|.||.|           :.::.....|   ||....:...|.|          .:
  Fly    22 HPHHSVPHGPLPPGMP-----------MPSLGPFGLPHGLEAVGFSQGMWGVN----------TR 65

Human    91 RQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQ 155
            :|||:||.||..||..|||.|.:.||||:..|||:|:..||.|:||:|||||||||.|::.:.||
  Fly    66 KQRRERTTFTRAQLDVLEALFGKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQLQQQQ 130

Human   156 ----AELCKNGFG-----------------PQFNGLMQPYDDMYPG------------------- 180
                ....||..|                 ...||.....:....|
  Fly   131 QSNSLSSSKNASGGGSGNSCSSSSANSRSNSNNNGSSSNNNTQSSGGNNSNKSSQKQGNSQSSQQ 195

Human   181 --------YSYNNWAAKGLTSA-------SLSTKSFPFFN------------SMNVNPLSSQSMF 218
                    .|.||.||...::|       |:.|....|.:            |.|.|..::....
  Fly   196 GGGSSGGNNSNNNSAAAAASAAAAVAAAQSIKTHHSSFLSAAAAAASGGTNQSANNNSNNNNQGN 260

Human   219 SPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDT 283
            |.|||.||.....|.....::....::..::...:..|||.|    ||||...:|
  Fly   261 STPNSSSSGGGGGSQAGGHLSAAAAAAALNVTAAHQNSSPLL----PTPATSVSP---------- 311

Human   284 CNSSLASLRLKAKQHSSFGYAS 305
                 .|:..| |:|.|.||.|
  Fly   312 -----VSIVCK-KEHLSGGYGS 327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX2	NP_000316.2	Homeodomain	93..149	CDD:459649	34/55 (62%)
		OAR	282..299	CDD:461067	3/16 (19%)
oc	NP_001356934.1	Homeodomain	68..123	CDD:459649	34/54 (63%)