Protein Alignment PITX1 and hbn

DIOPT Version :10

• Sequence 1: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_788420.1
• Gene: hbn / 47894
• FlyBaseID: FBgn0008636
• Length: 409
• Species: Drosophila melanogaster
• Alignment Length: 354
• Identity: 94/354 - (26%)
• Similarity: 145/354 - (40%)
• Gaps: 79/354 - (22%)

Human    20 RPAPAPGAPAAVPT---SMDAFKGGM-SLER--LPEGL---RPPPPPPH--------DMGPAFHL 67
            ||||...:|.:.|.   |:|...|.. .::|  .|..:   .|....||        :...:.||
  Fly    21 RPAPVQESPVSRPRAVYSIDQILGNQHQIKRSDTPSEVLITHPHHGHPHHIHHLHSSNSNGSNHL 85

Human    68 ARPADPREPLENSASESSD-----------TELPEKERGGEPKGPEDSGAGGTGCG-GADDPAKK 120
            :.....:...:...|:...           .:.|....||.....:|..:.....| ...|..:.
  Fly    86 SHQQQQQHSQQQHHSQQQQQQQQLQVQAKREDSPTNTDGGLDVDNDDELSSSLNNGHDLSDMERP 150

Human   121 KKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQ 185
            :|.||.||.||:.||.:||..|::.:|||:..||::|:..:|:|.||:|||:||||||||||:..
  Fly   151 RKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKREKFM 215

Human   186 QLDLCKGGY------VPQFS-GLVQP---------------YEDVYAAGYSYNNWAAKS--LAPA 226
            ..|  |.||      :|:|. |:..|               :...:|....:|..||.:  |.|.
  Fly   216 NQD--KAGYLLPEQGLPEFPLGIPLPPHGLPGHPGSMQSEFWPPHFALHQHFNPAAAAAAGLLPQ 278

Human   227 PLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGAV-------PGMP-----NSGLNNI 279
            .|....:...|..:.||.....|..:.|        .|.||.       .|.|     ::||:.:
  Fly   279 HLMAPHYKLPNFHTLLSQYMGLSNLNGI--------FGAGAAAAAAAASAGYPQNLSLHAGLSAM 335

Human   280 NNLTGSSLNSA--MSPGACPYGTP--ASP 304
            :.::....||:  .||...|:.||  |:|
  Fly   336 SQVSPPCSNSSPRESPKLVPHPTPPHATP 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	30/55 (55%)
		OAR	310..327	CDD:461067
hbn	NP_788420.1	Homeodomain	154..210	CDD:459649	30/55 (55%)