Protein Alignment PITX1 and toy

DIOPT Version :10

• Sequence 1: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_001368990.1
• Gene: toy / 43833
• FlyBaseID: FBgn0019650
• Length: 655
• Species: Drosophila melanogaster
• Alignment Length: 333
• Identity: 94/333 - (28%)
• Similarity: 131/333 - (39%)
• Gaps: 87/333 - (26%)

Human    54 PPPPPHDMGPAFHLARPAD-----PRE---PLENSASESSDTELPEKERGGEPKGPEDSGAGGTG 110
            ||.......|| :|:..||     .||   .:|.|.:.|.|:             ..|..:....
  Fly   199 PPAASVVTSPA-NLSGQADRDDVQKRELQFSVEVSHTNSHDS-------------TSDGNSEHNS 249

Human   111 CGGADDPAK---KKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFK 172
            .|..|...:   |:|.:|.||.|:::|:..||..|:|..|||:..||.:|....|.|.|::|||.
  Fly   250 SGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFS 314

Human   173 NRRAKWRKRER----NQQLDLCKGGYVPQFSGLVQPYEDVYAAGYSYNNWAAKSLAPAPLSTKSF 233
            |||||||:.|:    .:..|...|      ||...      .|.......|:.|:|.:..||...
  Fly   315 NRRAKWRREEKMRTQRRSADTVDG------SGRTS------TANNPSGTTASSSVATSNNSTPGI 367

Human   234 TFFNS--------MSPLSSQSMFSA---PSSI---SSMTMPSSMGPGAVPGMP----NSGLN--- 277
            .  ||        .|.|.|.|:..|   |:.:   ::.|..||..|...|..|    |||.|
  Fly   368 V--NSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAPRLPLNSGFNTMY 430

Human   278 ------------NINNLTGSSLNSAMSP-GACPYG-----TPASPY--SVYRDT-CNSSLASLRL 321
                        |.|:..||...|.:.. .|.||.     :..|||  :.:|:| ||.|.|  ..
  Fly   431 SSIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAA--HQ 493

Human   322 KSKQHSSF 329
            :..||..:
  Fly   494 QPPQHGVY 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	27/55 (49%)
		OAR	310..327	CDD:461067	6/17 (35%)
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	42/126 (33%)
		Homeodomain	267..322	CDD:459649	27/54 (50%)