Protein Alignment PITX1 and Ptx1

DIOPT Version :10

• Sequence 1: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Alignment Length: 308
• Identity: 136/308 - (44%)
• Similarity: 173/308 - (56%)
• Gaps: 83/308 - (26%)

Human    78 ENSASESSDTELPEKERGGEPKGPEDSGAGGTGCGGADDPAKKKKQRRQRTHFTSQQLQELEATF 142
            ||.:|...|.  |....|.|||..:                |.|:|||||||||||||||||.||
  Fly   237 ENISSSGHDE--PMTTSGEEPKNDK----------------KNKRQRRQRTHFTSQQLQELEHTF 283

Human   143 QRNRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQ------LDLCKGGYVPQFSGL 201
            .||||||||.|||||:||||||.|||||||||||||||||||..      .|. |.|:..||
  Fly   284 SRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWRKRERNAMNAAVAAADF-KSGFGTQF--- 344

Human   202 VQPYED--VYAAGYSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQ----------SMFSAPSSI 254
            :||:.|  :|:: |.||||   :..|:||.||.|.:  .::||.|.          :.|:..:|.
  Fly   345 MQPFADDSLYSS-YPYNNW---TKVPSPLGTKPFPW--PVNPLGSMVAGNHHQNSVNCFNTGASG 403

Human   255 SSMTM-PSSMGPGAVPGMPNSGLNNINNLTGSSLNSAMSPGA----CPYGTPASPYSVYR---DT 311
            .:::| .:||.||::               ||||::..:.||    |||.|||:|| :||   :.
  Fly   404 VAVSMNNASMLPGSM---------------GSSLSNTSNVGAVGAPCPYTTPANPY-MYRSAAEP 452

Human   312 C-----NSSLASLRLKSKQHSSFGYG---GLQGPAS-----GLNACQY 346
            |     :||:|:||||:|||:|.|:|   ....|.|     ||:||||
  Fly   453 CMSSSMSSSIATLRLKAKQHASAGFGSPYSAPSPVSRSNSAGLSACQY 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	50/55 (91%)
		OAR	310..327	CDD:461067	10/21 (48%)
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	50/55 (91%)