Protein Alignment PITX1 and toe

DIOPT Version :10

• Sequence 1: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_524041.2
• Gene: toe / 39418
• FlyBaseID: FBgn0036285
• Length: 640
• Species: Drosophila melanogaster
• Alignment Length: 723
• Identity: 136/723 - (18%)
• Similarity: 257/723 - (35%)
• Gaps: 199/723 - (27%)

Human    56 DKDAVYGV---PFSTDEPTDIIPRSCQLMTDVPH----VTQLLNMTKLRQTEIKFGGHPLRSAES 113
            ||...||.   .||...|||...|.....|.:.|    ..|:..:.:|.:|:...    :...:.
  Fly    34 DKTLPYGQYQNGFSARPPTDSYERDFLKQTMLEHEAVFKNQVYELHRLYRTQKSL----MAEVKG 94

Human   114 DQFINR--------GTSITR-----------NSKNQDVCHIAFGSKVLGPPPLSGRRNNMKI--- 156
            ..|::.        |:.|.|           .|.:|| |::...:|||...|:..||..:.:
  Fly    95 KNFVDHLNNNEPTPGSGIKRGFLFGNSICGEGSTSQD-CNVGKDNKVLEVRPVKVRRTMIDLQLP 158

Human   157 SSETVRSVGSKNNRSCQPSTVEKCV----------NGTEMSALLIPESEEQGNKENIHQIKQTVP 211
            :.|.:.:.|  :|.:|.|....|.|          |.:..|:||:..|....:.....|.:.:||
  Fly   159 ADEYLHTEG--DNTTCPPYEQSKEVGENIFFESHRNDSSGSSLLMKNSNGFTDLNEPVQCQDSVP 221

Human   212 I----------HAANL-HIMHPHPPQEPSADKNNNRRRLRL------KSTSRERTETPSGSSSGN 259
            :          :.||: |:      |....:||.::....:      |||.|::...||.|
  Fly   222 VSSSSRDLYSLYGANISHV------QGQWVEKNTSQNGWMVLEAGNGKSTPRDKLCLPSHS---- 276

Human   260 NRIEDKASTILTTVSQQGAELLNSGTLGPQSPDQSDEWIFPENADHISYLASSRQSLLLGDDSCN 324
                              .::|::....|..        :| :.|| |.|:..|.|........|
  Fly   277 ------------------VQVLSNSAFQPLG--------YP-STDH-SKLSGERASFKCEVRQRN 313

Human   325 PS---HLWLEASKES-----EHDQQAEESQSVPKDIFTFSSRPRSAPHGKTQTMSPEELSFILDL 381
            |.   ..::|:|..|     .|..:.|..:.....|.::.:|..|:........:...|:|...:
  Fly   314 PEVSYDSYVESSVASNVPSLNHGYRPESVRPWSHWISSWENRSSSSVQKPLPLQANPFLTFNTQV 378

Human   382 KEDNS--VTSRDTQSEDDFYGGDSSEEG--------NHSIQGSRGPTTGPS---ELTQLTLESLL 433
            :.|:|  :.|||:...:..:...|.|..        ||...|.:|..|..|   .:...:|::|.
  Fly   379 RADSSAEMRSRDSNGLNQGFSSFSEESAFNFPSVNFNHLNNGPKGAVTNGSLCESVMHQSLKNLQ 443

Human   434 GKAAKRTS--------KEYLRSAYTEAGATESQDSSMEQIDRNNFEMSLLPTTCLSP-TGRRCGS 489
            |...:..|        |...::..|..|...:..::.:.:|..:...|   :..:.| .|.|..:
  Fly   444 GPKKQECSSGLPWIKPKPLNKNGKTNGGLDLNASANHQFMDERDMGDS---SNYVHPQNGLRSVT 505

Human   490 CQKTPEPVIKAKDLSAQQVPASLNKTSLKEISG----ERLSSIPEASEYDWRNYQPSQMSES--- 547
            |         :.|.:.:.|..: |..|.::|.|    ::||...|         .||.::.|
  Fly   506 C---------SNDANLRHVEMA-NSQSRRKILGFPISQKLSICEE---------HPSLITSSVCI 551

Human   548 -----ELQMLASLRWQQNEELEDAGTSHGL---------SASQVDNCNVSISTSSDDTTTWNSCL 598
                 ::..|..:....|...| |..|.|:         :|:...:.:::...|.|:.:.:.|
  Fly   552 SNEPKKVNNLVKINLDINLPCE-ASVSEGVVVDKEEGNKAATHRQHIDLNFCASEDEDSGFCS-- 613

Human   599 PPPVNQGRHYQKEMNPPSPSNPRDWLNMLSPPIVPPSQQPA---EQRPDSCESLSVQGEEDLSVE 660
                          ||...:.....:|:.:|..:...::..   |:|.::.:|:     ::|...
  Fly   614 --------------NPRVETKATTLINVEAPLTLESEEEGGKFPEKRDEAGDSV-----DELIEA 659

Human   661 EDEEVLTL 668
            ..|.::|:
  Fly   660 AAEAIVTI 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	16/69 (23%)
		OAR	310..327	CDD:461067	4/19 (21%)
toe	NP_524041.2	HTH_ARSR	134..230	CDD:481197	21/97 (22%)
		Homeodomain	385..441	CDD:459649	12/55 (22%)