Protein Alignment PITX1 and Gsc

DIOPT Version :10

• Sequence 1: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_001137762.2
• Gene: Gsc / 33240
• FlyBaseID: FBgn0010323
• Length: 473
• Species: Drosophila melanogaster
• Alignment Length: 296
• Identity: 81/296 - (27%)
• Similarity: 110/296 - (37%)
• Gaps: 100/296 - (33%)

Human    13 RSQGGGARPAPAPGAPAAVPTSMDAF-KGGMSLERLPEG-------------------LRPPPPP 57
            |.||||.  ||:.|:..:...:.:.. ..|:||.....|                   :||...|
  Fly   173 RQQGGGT--APSQGSHISSNGNQNGLTSNGISLGLKRSGAESPASPNSNSSSSAAASPIRPQRVP 235

Human    58 PHDMGPAFHL------------ARPAD---------PREPLENSASESSDTELPEKERG------ 95
            .....|..||            |.|:|         |......:.:..:..::.....|
  Fly   236 AMLQHPGLHLGHLAAAAASGFAASPSDFLVAYPNFYPNYMHAAAVAHVAAAQMQAHVSGAAAGLS 300

Human    96 ----------GEPKGPEDSGAGGTG------CGGADDPAKKKKQRRQRTHFTSQQLQELEATFQR 144
                      |.|..|. .||...|      .|....|   |::||.||.||.:||::|||||.:
  Fly   301 GHGHHPHHPHGHPHHPH-LGAHHHGQHHLSHLGHGPPP---KRKRRHRTIFTEEQLEQLEATFDK 361

Human   145 NRYPDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCK----------GGYVPQFS 199
            ..|||:.:||::|:..:|.|.||.||||||||||||::|.:|..|.|          .|.....|
  Fly   362 THYPDVVLREQLALKVDLKEERVEVWFKNRRAKWRKQKREEQERLRKLQEEQCGSTTNGTTNSSS 426

Human   200 GLVQ-----------PYEDVYAA----------GYS 214
            |...           |..|.|:|          |||
  Fly   427 GTTSSTGNGSLTVKCPGSDHYSAQLVHIKSDPNGYS 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	33/55 (60%)
		OAR	310..327	CDD:461067
Gsc	NP_001137762.2	Homeodomain	341..397	CDD:459649	33/55 (60%)