Protein Alignment PITX1 and al

DIOPT Version :10

• Sequence 1: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_722629.1
• Gene: al / 33208
• FlyBaseID: FBgn0000061
• Length: 408
• Species: Drosophila melanogaster
• Alignment Length: 411
• Identity: 108/411 - (26%)
• Similarity: 153/411 - (37%)
• Gaps: 153/411 - (37%)

Human    42 MSLERLPEGLRPPPPPPHDMGPAFHLARP-----ADPREPLENSASESSDTELPEKERGGEPKGP 101
            :.||.||:..:              ||.|     .| |.|..::||..:...:.....||.|.|.
  Fly     7 IKLEELPQEAK--------------LAHPDAVVLVD-RAPGSSAASAGAALTVSMSVSGGAPSGA 56

Human   102 EDSGA-GGTG---------CGGADDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEI 156
              ||| |||.         | .||:.|.|:||||.||.|||.||:|||..|.|..|||:..|||:
  Fly    57 --SGASGGTNSPVSDGNSDC-EADEYAPKRKQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREEL 118

Human   157 AVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQ------------------ 203
            |:...|||.|::|||:||||||||:|:..........|:|..:..:|
  Fly   119 AMKIGLTEARIQVWFQNRRAKWRKQEKVGPQSHPYNPYLPGGAATMQTVVGAALPPNPFTHLGFQ 183

Human   204 ---PYEDVYA---AGYSYNNWAAKSLAPAPLSTKSFTFFNS-------MSPLSSQSMFSAPSSIS 255
               |::..:|   |.:.|.:.:|..:.|:       .:||.       |.|.....|:|..||..
  Fly   184 LRKPFDAQHAANLAAFRYPHLSAAPMIPS-------GYFNQFQRAPPHMLPHGMAGMYSPSSSFQ 241

Human   256 SMT---------MPSSMGPGAVPGMPNSGLNNINNLTGSSLNSAMS------------------- 292
            |:.         .|....|..:.|.|:  |::.|::..|...|..|
  Fly   242 SLLANMTAVPRGTPLGKPPALLVGSPD--LHSPNHMLASPPTSPASGHASQHQQHPTAHPPPPQA 304

Human   293 PGACPYG-------------------------TPASPYSVY------------------------ 308
            |...|.|                         |..||.::.
  Fly   305 PPQMPVGVQPAQLSPQHLVGIALTQQASSLSPTQTSPVALTLSHSPQRQLPPPSHQAPPPPPRAA 369

Human   309 ---RDTCNSSLASLRLKSKQH 326
               .|...||:|:||||:::|
  Fly   370 TPPEDRRTSSIAALRLKAREH 390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	34/55 (62%)
		OAR	310..327	CDD:461067	9/17 (53%)
al	NP_722629.1	Homeodomain	86..142	CDD:459649	34/55 (62%)
		OAR	374..391	CDD:461067	9/17 (53%)