Protein Alignment PITX1 and Vsx1

DIOPT Version :10

• Sequence 1: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_572232.2
• Gene: Vsx1 / 31470
• FlyBaseID: FBgn0263511
• Length: 837
• Species: Drosophila melanogaster
• Alignment Length: 367
• Identity: 93/367 - (25%)
• Similarity: 123/367 - (33%)
• Gaps: 120/367 - (32%)

Human     9 GELGR------SQGGGARPAPAPGAPAA----VPTSMDAFKGGMSLERLPEGLRPPPPPPHD--- 60
            |.||.      ..||||....:.|....    ..||.:...||.|      |.|..|..||.
  Fly   235 GHLGSPTASNGGSGGGAGVGGSGGGSGTSGSNSSTSGNGGNGGSS------GSRSSPAGPHHSAA 293

Human    61 ----------MGPAFHLARPADPREPLENS------------------ASESSDTELPEKE---- 93
                      ...|.|.|..|.......::                  |:.::.......|
  Fly   294 LAAHQHAAAAAAAAHHHAAAAAAAHHAHHAHAQAHAHAHAHVHAHAAHAAHAAHAHAHHAEAFLG 358

Human    94 ----RGGEPK-------GPEDSGAGGTGCGGADDPAKKKKQRRQRTHFTSQQLQELEATFQRNRY 147
                .||.|.       |....|.||||.||    .||.|:|..||.|||.||:|||..|:...|
  Fly   359 AAGGAGGNPNSLLAAHGGDVLVGPGGTGPGG----KKKNKRRHGRTIFTSSQLEELEKAFKEAHY 419

Human   148 PDMSMREEIAVWTNLTEPRVRVWFKNRRAKWRKRERNQQLDLCKGGYVPQFSGLVQPYEDVYAAG 212
            ||:|.||.:::.|.|.|.|::||::||||||||.|:      |.|             .....|.
  Fly   420 PDVSARELLSMKTGLAEDRIQVWYQNRRAKWRKTEK------CWG-------------HSTKMAE 465

Human   213 YSYNNWAAKSLAPAPLSTKSFTFFNSMSPLSSQSMFSAPSSISSMTMPSSMGPGAVPGMPNSGLN 277
            |.......:...|.|                       .:.|.|.....|:.|..: ||....|.
  Fly   466 YGLYGAMVRHSLPLP-----------------------ETIIKSAKEDESVAPWLL-GMHKKSLE 506

Human   278 NINNL----------TGSSLNSAMSPGACPYGTPASPYSVYR 309
            ....|          |....|::.|.|: .:.:|.|.:|:.|
  Fly   507 AAELLKSDESDRETPTSDDTNTSYSAGS-THNSPISSFSISR 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	30/55 (55%)
		OAR	310..327	CDD:461067	93/367 (25%)
Vsx1	NP_572232.2	Homeodomain	395..452	CDD:459649	30/56 (54%)