Protein Alignment PITX1 and Vsx2

DIOPT Version :10

• Sequence 1: XP_047273274.1
• Gene: PITX1 / 5307
• HGNCID: 9004
• Length: 348
• Species: Homo sapiens
• Sequence 2: NP_001284897.1
• Gene: Vsx2 / 31469
• FlyBaseID: FBgn0263512
• Length: 645
• Species: Drosophila melanogaster
• Alignment Length: 363
• Identity: 96/363 - (26%)
• Similarity: 132/363 - (36%)
• Gaps: 115/363 - (31%)

Human    53 PPPPPPHDMGPAFHLARPADPREPLEN--------SASESSDTELPEKERGGEPKGPEDSGAGG- 108
            ||||||..    .|  .|..|..||.:        |.:..:.|.||..      ..|:|.|...
  Fly   162 PPPPPPMQ----HH--HPHHPHHPLLHAQGFPQLKSFAAGAGTCLPGS------LAPKDFGMESL 214

Human   109 TGCG-GADDPAKKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSMREEIAVWTNLTEPRVRVWFK 172
            .|.| |.:...||||:|..||.|||.||::||..|:...|||:..||.:::.|.|.|.|::|||:
  Fly   215 NGFGVGPNSKKKKKKRRHSRTIFTSYQLEKLEEAFKEAHYPDVYAREMLSLKTELPEDRIQVWFQ 279

Human   173 NRRAKWRKRER------------------NQQLDL---------CKGGYVPQFSGL--------- 201
            ||||||||.|:                  ...|.|         ......|...|:
  Fly   280 NRRAKWRKTEKVWGGSTIMAEYGLYGAMVRHSLPLPDTILKSAKDNDAVAPWLLGMEQKCMHRKS 344

Human   202 ------------VQPYEDVYAAGYSYNNWAAKSLAPA-PLSTKSFTFFNSMSPLSSQSMFSAPSS 253
                        |..:||...:..:::...::|...| ..||:|   .|.:||..|    |.|:|
  Fly   345 IEAQSALKDDSGVSDHEDSAGSKSAHSEDLSRSRCHALSSSTES---LNVVSPAPS----SCPTS 402

Human   254 ISSMTMPSSMGPGAVPGMPNSGLNNINNLTG-SSLNSAMSP------------------------ 293
            .|:...|:|     ..|...:..:.....|| |:.||:.||
  Fly   403 ASTSAPPTS-----TSGYAGAASSAATTPTGASTTNSSSSPHIELGSPSPQQQQHLQLQQQQQQQ 462

Human   294 -------GACPYGTPASPYSVYRDTCNSSLASLRLKSK 324
                   ||...|.....|....|..|::.|.....||
  Fly   463 ASLYLGAGAVVTGCAPPSYHPLLDAANAAGAGAAASSK 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PITX1	XP_047273274.1	Homeodomain	124..180	CDD:459649	29/55 (53%)
		OAR	310..327	CDD:461067	5/15 (33%)
Vsx2	NP_001284897.1	Homeodomain	230..287	CDD:459649	29/56 (52%)
		OAR	556..572	CDD:461067