Protein Alignment PIP4K2A and PIP5K59B

DIOPT Version :10

• Sequence 1: NP_005019.2
• Gene: PIP4K2A / 5305
• HGNCID: 8997
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_001369113.1
• Gene: PIP5K59B / 37633
• FlyBaseID: FBgn0034789
• Length: 891
• Species: Drosophila melanogaster
• Alignment Length: 454
• Identity: 117/454 - (25%)
• Similarity: 211/454 - (46%)
• Gaps: 65/454 - (14%)

Human     1 MATPGN------------LGSSVLASKTKTKKKHFVAQK---------VKLFRASDPLLSVLMWG 44
            :|.|.|            ||:....:.:|..|:..:..:         .|..:.|. ::..:..|
  Fly    24 LAEPSNASTDHVGNSSPDLGNRPNRASSKADKERKIGHRRVGEGGEITYKKIQTSQ-IMGSIQLG 87

Human    45 VNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKEN---MPSH----FKFKEYCPMVFRNLR 102
            :.|::..|:......:||.|.:      ::::..|..|.   .|:|    |::|.|.|:.||..|
  Fly    88 IQHTVGSLASKPKRDLLMMDFW------EIESITFPPEGSSLTPAHHYSEFRYKIYAPIAFRYFR 146

Human   103 ERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIV 167
            :.|||...||..|:..|......:...||:.|:.:.|..:||||:..::...:..:|..|:..:.
  Fly   147 DLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLLPGYYMNLN 211

Human   168 ECHGITLLPQFLGMYRLNVDGVE-IYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELP 231
            : :..||||:|.|:|.|.....: |.::|..|:....:.::.||||||||..|:|:..|:||:.|
  Fly   212 Q-NPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANKAERAKKSP 275

Human   232 TLKDNDFINEGQK-IYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVE--- 292
            |.||.||:.:... |:::.......::.:::|...|...|:||||||:|:|:::.|.:|:..
  Fly   276 TYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQR 340

Human   293 -------CEENDGEEEGESDGTHPVGTPPDSPGNTLNSSPPLA-------------PGEFDPNID 337
                   .|::|.:.:...||....|.   |...::|....:|             |.:.:.::.
  Fly   341 KPLRAPLAEDSDVDADDPLDGDAATGI---SRNKSVNRQRLVAHSTAMESIQAESEPIDDEEDVP 402

Human   338 VYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFI 401
            ..||........:.:.::.|||||..|..|||..|..|::.|. |..:|...|..|::||.:|:
  Fly   403 PGGIPARSEKGERLLLYIGIIDILQSYRLKKKLEHTFKSIIHD-GETVSVCRPSFYAQRFQNFM 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K2A	NP_005019.2	PIPKc_PIP5K2A	27..403	CDD:340446	110/416 (26%)
		Required for interaction with PIP5K1A. /evidence=ECO:0000250|UniProtKB:Q8TBX8	59..65		2/5 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..329		9/63 (14%)
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	109/400 (27%)