Protein Alignment PIP4K2A and sktl

DIOPT Version :10

• Sequence 1: NP_005019.2
• Gene: PIP4K2A / 5305
• HGNCID: 8997
• Length: 406
• Species: Homo sapiens
• Sequence 2: NP_477206.1
• Gene: sktl / 37356
• FlyBaseID: FBgn0016984
• Length: 792
• Species: Drosophila melanogaster
• Alignment Length: 474
• Identity: 118/474 - (24%)
• Similarity: 202/474 - (42%)
• Gaps: 100/474 - (21%)

Human     7 LGSSVLASKTKTKKKH--------------FVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQI 57
            |.:|:..:.:.|..||              ...:|::    |..::..:..|:.|::..|:
  Fly   119 LDASISRNPSTTGGKHEKKLGHRRVAEGGEVTYKKIQ----SKQIMGSIQLGIQHTVGSLA---- 175

Human    58 PVMLMPDDFKAYSKIKVD---NHLFNKENM----------PSH----FKFKEYCPMVFRNLRERF 105
                        ||.|.|   |..:..|.:          |:|    |:||.|.|:.||..|:.|
  Fly   176 ------------SKPKRDLLMNDFWEMETISFPPDGSSITPAHHYNDFRFKVYAPIAFRYFRDLF 228

Human   106 GIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYIIKTITSEDVAEMHNILKKYHQYIVECH 170
            ||...||..|:..|......:...||:.|:.:.|..:||||:..::...:..:|..|:..:.: :
  Fly   229 GIAPDDFLMSMCASPLRELSNPGASGSIFYLTTDDEFIIKTVQKKECEFLQKLLPGYYMNLSQ-N 292

Human   171 GITLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKD 235
            ..||||:|.|:|..:.:...:.::...|:....:.::.|||||||:..|:||..|:.|..||.||
  Fly   293 PRTLLPKFFGLYCFHYNSKNVRLVAMNNLLPSDIKMHCKYDLKGSSFRRKASKAERQKASPTFKD 357

Human   236 NDFI-NEGQKIYIDDNNKKVFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVE------- 292
            .||. :....|:::.:.....:..:|:|...|...::||||||||||:::.|.:|:.|
  Fly   358 LDFAEHHPNGIFLETDKYNALMSTIKRDCMVLESFQIMDYSLLVGIHNLDLAAKEKREERILNAR 422

Human   293 ---------------CEENDGEEEGESDGTHPVGT----PPDSPGNTLNSSPPL----------- 327
                           ...:|...|.:.:....|.:    |..|.|..||.:..:
  Fly   423 AKLQRKESAAQGPPSLNPDDDAPEADQNQLQAVASYASIPGTSAGAALNRTRSMNRQRLVAHSTA 487

Human   328 ---------APGEFDPNIDVYGIKCHENSPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGA 383
                     .|.|.|.::...||.....:..:.:.::.|||||..|..:||..|..|::.:. |.
  Fly   488 LESITADMDVPLEEDEDVPAGGIPARSENDERLILYIGIIDILQSYRLEKKLEHTFKSILYN-GD 551

Human   384 EISTVNPEQYSKRFLDFIG 402
            .:|...|..|:|||.|.:|
  Fly   552 TVSVCRPSFYAKRFQDAMG 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIP4K2A	NP_005019.2	PIPKc_PIP5K2A	27..403	CDD:340446	113/440 (26%)
		Required for interaction with PIP5K1A. /evidence=ECO:0000250|UniProtKB:Q8TBX8	59..65		0/5 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	288..329		10/86 (12%)
sktl	NP_477206.1	PIPKc_PIP5KI	158..577	CDD:340438	111/431 (26%)