Protein Alignment PI4KB and fwd

DIOPT Version :10

• Sequence 1: XP_011507936.1
• Gene: PI4KB / 5298
• HGNCID: 8984
• Length: 849
• Species: Homo sapiens
• Sequence 2: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Alignment Length: 962
• Identity: 362/962 - (37%)
• Similarity: 522/962 - (54%)
• Gaps: 191/962 - (19%)

Human    32 GPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEK------------VKLLHGGVAVSSR- 83
            |.|  ||||.:              |:...|:..::.:|            :|......|.|:.
  Fly   760 GSP--NGGSSV--------------PQDLVKSPTDISKKKEFFSLLTSSSSIKAAAAAAANSAAS 808

Human    84 ---GTPLELVNGDGVDSEIRCLDDPPAQIR------------EEEDEMGAAVASGTAKGARRRR- 132
               .||.|.:..:. :|:::.|.||.|.::            :.|...||.....:.....:.:
  Fly   809 TPPATPTEALAANS-NSKLQPLSDPSADLKVKERTLNLRLPGDSEGSEGALTKCSSINSIHKLKL 872

Human   133 --------------------QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLF 177
                                |.....||.|||.|||.:|:|..|:.||:.||||||.::|||::|
  Fly   873 PVPGVVKYFISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGNKIF 937

Human   178 CFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRH 242
            .|.:::||.|:|||:.|||.||| :.:.:.||:..|||:|::|||:|..||.||:..:......|
  Fly   938 SFPDQEVDLYIPQLVVMYIQMDE-LAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSH 1001

Human   243 SRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGL---------SPSKRTHQRSKSDATA----- 293
            :...|.:..::.:.......|:....|..|...||         :.:|:||.||:||||.
  Fly  1002 NSSRKSKLALMKEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADF 1066

Human   294 ----SISLSSNLKRTASNPKVENEDEELS---------SSTESIDN------------------- 326
                ::|:|   .|....|....:....:         :|..:.||
  Fly  1067 RSPHTLSIS---HRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQR 1128

Human   327 ---SFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPT-AGFD 387
               |..:| :.:|::||:|:||.:||.|.:.|:|.:||..|...|:|:|..||||||||. :...
  Fly  1129 TLCSCGAP-KTSPQKEFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKNLPARVWLPLYSDIP 1192

Human   388 HHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTS-VPARIPENRIRSTRSVENLP-ECGIT 450
            |||||:...:..|||||||.||:|||||:|..:..|:. :|..:|.  :|.|:|.|:|. .|..:
  Fly  1193 HHVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPS--LRHTKSEEHLDGSCLNS 1255

Human   451 HEQ-------------------------------RAGSFSTVPNYDN-------DDEAWS--VDD 475
            |:.                               .||..::..|..:       :|:.||  .|:
  Fly  1256 HQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEEDE 1320

Human   476 IGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPT-AFKRDPED 539
            |....:.:.:|  :..|.|||.|:||..|::...||....||:|.|....|:...| :|..||||
  Fly  1321 ITAQYLNMRKV--SERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFSNDPED 1383

Human   540 PSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVP 604
            |||.||||||.||.:.|||.||||||.||||||.||||||||||||:|.|:|:..:.||::|:|.
  Fly  1384 PSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVD 1448

Human   605 LWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSC 669
            ||::||||:.:|.|||:|||::|.||:||:||.|..||.:||:.|:||.:.|:|..||:||||||
  Fly  1449 LWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSC 1513

Human   670 AGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLD 734
            |.|||:.||||||||||||||..::|||||||||||||.||:|||||.|.||||.|||:||||..
  Fly  1514 AAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGFEQSPFKLTPEFVEVMGGTS 1578

Human   735 GDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGCRRCSGSSPSGPMMTVAQVICSQLPCFHG- 798
            .:.:..:..|:|.|:::||||||:::..||||:..                     :.||||..
  Fly  1579 SEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSN---------------------AHLPCFKNG 1622

Human   799 -SSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM 849
             |.|::||::||||::||::::..|||:|..|::|::||||||:||.||||:
  Fly  1623 CSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGIL 1674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PI4KB	XP_011507936.1	PI4KB_NTD	14..78	CDD:412074	10/57 (18%)
		PI4Kc_III_beta	541..849	CDD:270712	176/309 (57%)
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	176/309 (57%)