DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PI4KB and Pi3K59F

DIOPT Version :9

Sequence 1:	XP_011507936.1	Gene:	PI4KB / 5298	HGNCID:	8984	Length:	849	Species:	Homo sapiens
Sequence 2:	NP_477133.1	Gene:	Pi3K59F / 37733	FlyBaseID:	FBgn0015277	Length:	949	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	153/759 - (20%)
Similarity:	270/759 - (35%)	Gaps:	220/759 - (28%)

- Green bases have known domain annotations that are detailed below.

Human   141 WLLRLFESKLFDISMAISYLYNS-KEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGD 204
            |:|..:..  .|:..|:..|..: ..|.|:.|..:||....:||:..||.||:....:.|
  Fly   352 WMLANWAP--MDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYED----- 409

Human   205 AIKPYIVH------------RCRQSINFSL--QCALL-LGAYSSDMHIST-QRHSRGTKLRKLIL 253
              ..:|||            |.....|.||  |.:|. |.|.||.:|.|. ..:.|...:...|.
  Fly   410 --PRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLAAIK 472

Human   254 SDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELS 318
            ||:           |:||....|          |.|....|::|        .||.........|
  Fly   473 SDK-----------SVSPGSAGG----------SGSGGQGSVAL--------PNPSAPATPGSSS 508

Human   319 SSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTK--EQKTQRLISELSLLNHKLPARVWL 381
            ...:|..|:.               ::|.|....::|..  ....||..:..:|.|:    ..|
  Fly   509 LPCDSNSNAL---------------MLAEGISFGSVPANLCTFLIQRACTNATLANY----FYW- 553

Human   382 PTAGFDHHVVRVPHTQAVVLNSKDKAPYLIY-------VEVLECENFDTTSV------------- 426
                  :..:.|...::|  ..:|:..:.:|       ::|||..||:...:
  Fly   554 ------YLSIEVEEVESV--RKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDE 610

Human   427 -------PARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELP 484
                   .|:.|.||.:.|...:.|.......:....:|..:|        :.:|         |
  Fly   611 LVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIP--------FPLD---------P 658

Human   485 EVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLS--EQLAHTPTAFKRDPEDPSAVALKE 547
            |::              ||...........:..:..:|:  ..:||...|
  Fly   659 EIY--------------ITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYA--------------- 694

Human   548 PWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI 612
                                     .|.|.||||||:.|..|::..:..:..:|.:.|.:.|||:
  Fly   695 -------------------------AIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKV 734

Human   613 LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEH----GSYTTEAFLSAQRNFVQSCAGYC 673
            |..|:..|.::.|.:......:.::..:.  ::|.:.|    |.|...|  .....:::||||||
  Fly   735 LATSSKHGFLQYVDSCTVAEVLAREGNIH--NFFRKHHPCDNGPYGISA--EVMDTYIKSCAGYC 795

Human   674 LVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMF 738
            ::.|||.|.|||..|:||...|.:.|||||:||...|:.:   ....||:.|.|:.|||:..:..
  Fly   796 VITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPM---PPPMKLSKEMVEAMGGISSEHH 857

Human   739 NYYKMLMLQGLIAARKHMDKVVQIVEIMQQGCRRCSGSSPSGPMMTVAQVICSQLPCFHGSSTIR 803
            :.::.......:..|:|.:.::.:..:|...              ||..:      .......::
  Fly   858 HEFRKQCYTAYLHLRRHANVMLNLFSLMVDA--------------TVPDI------ALEPDKAVK 902

Human   804 NLKERFHMSMTEEQ----LQLLVEQMVDGSMRSITTKLYDGFQY 843
            .::|...:.:|:|:    ||.|::..:...|.::..:::...||
  Fly   903 KVEENLQLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQY 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PI4KB	XP_011507936.1	PI4Kc_III_beta	541..849	CDD:270712	70/311 (23%)
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042
		PI3Ka_III	284..561	CDD:238442	58/272 (21%)
		PI3Kc_III	601..945	CDD:270628	85/441 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810