DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PI4KB and mei-41

DIOPT Version :9

Sequence 1:	XP_011507936.1	Gene:	PI4KB / 5298	HGNCID:	8984	Length:	849	Species:	Homo sapiens
Sequence 2:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster

Alignment Length:	1093	Identity:	194/1093 - (17%)
Similarity:	348/1093 - (31%)	Gaps:	414/1093 - (37%)

- Green bases have known domain annotations that are detailed below.

Human    57 PEVAQKACQEVLE-------KVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEED 114
            |.:|.|.|.|:|:       :.:.:||.   |:.|.|.|.     :||..|       :|.|..:
  Fly  1454 PRLAGKLCAELLDFLQRWLREWQRIHGR---STGGKPPET-----IDSNYR-------KIHEFLN 1503

Human   115 EMGAAVASGTAKGARRRRQNNSAKQSWL-------LRLFESKLFDISMAISYLYNS-KEPG---- 167
            .:...:.|..:.......:..|..:|:|       .||.|...|.:.     :|.| ::|.
  Fly  1504 LIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRLLEQFTFLVE-----VYGSLRDPDSVEG 1563

Human   168 ---VQAY--------IGNRLFCFRNEDVDFYLPQLLNMYIHMDED-VGDAIKPYIVHR------- 213
               |::|        :.||| ..|.:|:.....|||:....|..| |...|..|:...
  Fly  1564 AVQVRSYDMSVTQDILVNRL-VERQQDMITSYEQLLSSTDQMQPDHVRAMIDAYLRDTPKTAQLI 1627

Human   214 -----CRQSINFSLQC------ALL--LGAYSSDMHISTQ---RHSRG-TKLRKLILS----DEL 257
                 .|.|..:|.||      .||  ||:|.....:.:.   :.|:| .|||:.:.:    |.|
  Fly  1628 ADGLWQRLSDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQCSQGCLKLRRPLTTRIEFDSL 1692

Human   258 KPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVE--NEDEELSSS 320
            ....|:..|..|     ...|..::....:..||...:.|...|.  .|...||  .:|.:..:.
  Fly  1693 LDGMRESVLEEL-----RSCSAVQQHSYANAYDAVLKLHLVHELH--CSQELVEKLEQDRDEDNQ 1750

Human   321 TESIDNSFSS-PVRL---APEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLP----- 376
            .:.:.|.|.. ..||   .|:....:|:.:..:.:..      :.||.:::   .||.||
  Fly  1751 EKLMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILA------ELQRRLTD---RNHLLPHLKTE 1806

Human   377 -ARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVE----------------VLE------- 417
             ||:||.:|..:.:..::...|..:|.:.:..|..:::|                .||
  Fly  1807 LARIWLNSAQINRNAGQLQRAQLYILKAAEYQPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMR 1871

Human   418 --CENFDTTSVPARIPENR--------IRSTRSVENLPECG-----------ITHEQ-------- 453
              |:.    :|.....|.|        :::..|.|::..|.           ..|.|
  Fly  1872 SGCQG----NVKQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQM 1932

Human   454 -------------------------------------RAGS---FSTVPN-----YDNDDEAWSV 473
                                                 |.||   :.::|.     .|..:.:.:.
  Fly  1933 AQFLEKILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNT 1997

Human   474 DDIGELQVELPEVHTNSCDNI---------SQ------------FSV------------------ 499
            :.:.::.    ::.||.|..:         ||            |:|
  Fly  1998 EQVKKMN----DLLTNCCTALPTAVFYTVYSQMLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLW 2058

Human   500 ----------------------DSITSQESKEPVFIAAGDIRRRLSE------------QLAHTP 530
                                  ||.....:.:.:......:..||.:            :|:...
  Fly  2059 MLLPHFKSAKAHRIKRCKLVLTDSRLQNSTFQKLLQDFNSLTERLMDLTNKEVTLDRTYKLSDLD 2123

Human   531 TAFKRDPEDPSAVALKEPWQEKVR---------RIREGSPYGHLP------NW------------ 568
            |...:..:.|....:..|:::.::         ...|||   |||      ||
  Fly  2124 TRLSKLCKQPEFSQILLPFEKYMQPTLPLNSDSNSSEGS---HLPANQSTVNWFPYQQIYISGFQ 2185

Human   569 ----------------------RLLSVIVKCGDDLRQE--LLAFQ--VLKQLQSIWEQERVPLWI 607
                                  :...|:||..||||::  |:.|.  |.:.|.......:..|.|
  Fly  2186 ESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHI 2250

Human   608 KPYKILVISADSGMIEPVVN---------------------------AVSIHQVKKQSQLSLLDY 645
            :.|.:|..:.:.|::|.:.|                           ||.:|:..::.:......
  Fly  2251 RTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQ 2315

Human   646 FLQEHGSY----------TTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILL-DAEGHIIH 699
            .:..|...          |..::..|:..::::.|...:|.|:|.:.|||..|||. :..|..:|
  Fly  2316 LVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVH 2380

Human   700 IDFGFILSSSPRNLGFETSAFKLTTEFVDVMG--GLDGDMFNYYK----------------MLML 746
            :||..:.:........|...|:||...:..||  |::|   ::.|                |.:|
  Fly  2381 VDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEG---SFRKCCEITLRLLKQESKTLMSIL 2442

Human   747 QGLI----------AARKHMDKVVQ-IVEIMQQGCRRCSGSSPSGPMMTVAQV 788
            :..:          ||...:.|.|| |.:.:|...:|...:|.  |:.|..||
  Fly  2443 RPFVYDVGAQTRKGAATAKITKDVQRIADRLQGHVKRQQANSI--PLSTEGQV 2493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PI4KB	XP_011507936.1	PI4Kc_III_beta	541..849	CDD:270712	71/368 (19%)
mei-41	NP_523369.2	UME	955..1060	CDD:214825
		FAT	1653..1985	CDD:280429	58/351 (17%)
		PIKKc_ATR	2181..2448	CDD:270625	49/269 (18%)
		FATC	2486..2517	CDD:280430	4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900