DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PI4KB and nonC

DIOPT Version :9

Sequence 1:	XP_011507936.1	Gene:	PI4KB / 5298	HGNCID:	8984	Length:	849	Species:	Homo sapiens
Sequence 2:	NP_001284967.1	Gene:	nonC / 31625	FlyBaseID:	FBgn0263968	Length:	3218	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	131/745 - (17%)
Similarity:	234/745 - (31%)	Gaps:	249/745 - (33%)

- Green bases have known domain annotations that are detailed below.

Human   124 TAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYL 188
            :..|..:........|...|.:.:|.|...::.:..|......|:|..:...|...........:
  Fly  1585 SGSGPEKPEGEGVVSQRERLHVDDSNLVTTTLRLLRLIVKHASGLQEVLEQGLHTTPIAPWKVII 1649

Human   189 PQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLR-KLI 252
            |||.:...|.:        ||:    |:|:     |.||               .|..|.| :|:
  Fly  1650 PQLFSRLNHHE--------PYV----RKSV-----CDLL---------------CRLAKSRPQLV 1682

Human   253 LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENE---- 313
            :...:..|:|:::..:..||          |.:.:..||.....|...|.:.|  |:....
  Fly  1683 IFPAVVGANREQQDATAPPA----------TARPTTEDACCYGYLLGELSKQA--PEAVQHVKLM 1735

Human   314 -----------DEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPT------KEQKT 361
                       ||....|...|.|::.|                   |::.|.|      .|.|.
  Fly  1736 VKELRRVCLLWDEYWIHSLAHIYNTYVS-------------------RVSALATDFRPDDHEGKN 1781

Human   362 QRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSV 426
            .|.             .||.|....|        .:|:|..: .:.|...|..... :.||   .
  Fly  1782 NRF-------------NVWRPQLLAD--------LEALVAVT-SRPPETTYERSFR-KRFD---A 1820

Human   427 PARIPENRIRSTRSVENLPECG---------ITHEQRAGSFSTVPNYDNDDEAWSVD----DIGE 478
            |.|:..:.:|..|    .||..         :......||.||:       :..|:.    .||.
  Fly  1821 PIRLTVDALRHRR----YPEAWDKLKQLYHILQSNMIRGSGSTL-------KMQSISPVLCGIGR 1874

Human   479 LQVELP--EVHTNSCDNISQFSVDSI-----TSQESKEPVFIAAGDIR----------RRLSEQL 526
            :::.:|  :.|....|.:...||:|.     |..:.|:..|..:...|          ..|.|::
  Fly  1875 MRISMPGLDAHGPDGDQVYIESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERI 1939

Human   527 ------------------------AHTPTAFKRDPED---------PSAVALKEPWQEKVRRIRE 558
                                    ||..:.....|:.         ....||.:.||::..::..
  Fly  1940 MQFLSISNAIMACRSDAPGNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRSQVAG 2004

Human   559 GSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIE 623
            .:..|.:.|                      |.::...::..:..||..|
  Fly  2005 NAGAGAVAN----------------------VPRRFTDLFYNKLSPLLAK--------------- 2032

Human   624 PVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQ---------------RNFVQSCAGYC 673
               :.:.:...::|..:|:|...|.|....|....|:.:               |.||:..:...
  Fly  2033 ---HNMQVSDPRRQWPISVLLQVLDELSQETPNDLLARELWCQAGNAAEWRQSVRRFVRCMSVMS 2094

Human   674 LVCYLLQVKDRHNGNILLD-AEGHIIHIDFGFILSSSPRNLGF-ETSAFKLTTEFVDVMG--GLD 734
            ::.|::.:.|||..|:|:: ..|.|:|||:. :.....|.|.. |...|:||...|..||  |::
  Fly  2095 MIGYVIGLGDRHLDNVLINLGSGDIVHIDYN-VCFEKGRTLRIPEKVPFRLTQNLVQAMGITGIE 2158

Human   735 GDMFNYYKMLMLQGLIAARKHMDKVVQIVE 764
            |.    :::.....|...||..:.::.::|
  Fly  2159 GP----FRLGCEYVLKVMRKERETLLTLLE 2184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PI4KB	XP_011507936.1	PI4Kc_III_beta	541..849	CDD:270712	46/243 (19%)
nonC	NP_001284967.1	SMG1	571..1140	CDD:292413
		Rapamycin_bind	1738..1845	CDD:285924	28/155 (18%)
		PIKKc_SMG1	1894..2196	CDD:270714	58/336 (17%)
		FATC	3189..3217	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900