Protein Alignment PI4KB and Pi4KIIIalpha

DIOPT Version :10

• Sequence 1: XP_011507936.1
• Gene: PI4KB / 5298
• HGNCID: 8984
• Length: 849
• Species: Homo sapiens
• Sequence 2: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Alignment Length: 884
• Identity: 208/884 - (23%)
• Similarity: 342/884 - (38%)
• Gaps: 252/884 - (28%)

Human    44 VITEGVGELSVIDPEVAQK---ACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDP 105
            ::|..||:..:.:..|:..   |.:...|...|:.||..|:.....:. .:|:.|.
  Fly  1442 LVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMS-ASGNAVG--------- 1496

Human   106 PAQIREEEDEMGAAVASG--------------------TAKGARRRRQNNSAKQSWLLR---LFE 147
                      ||..||.|                    :.:..|.:.|.:|..:.::.:   :.|
  Fly  1497 ----------MGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILE 1551

Human   148 SKLFDISMAISYLYNSKE------PGVQAYI--GNR-------------LFCFRNEDVDFYLPQL 191
            ....::...|:: ||...      ||.:...  .||             .:|: |..:..:|||.
  Fly  1552 LLAVELEFLITW-YNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCY-NPALAVFLPQR 1614

Human   192 LNMYIHMDEDVGDAI--KPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILS 254
            :.....:||:|...:  .|..|....:::.:......||......::|.:  .|..|.::.|...
  Fly  1615 IKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILS--WSPVTPIQALAYF 1677

Human   255 DELKPAH---RKRELPSLSPAPDTGLSP--------------------SKRTHQRSKSDATASI- 295
            ....|:|   .:..:.:||..|...:.|                    .|...:||:..|...|
  Fly  1678 SRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIW 1742

Human   296 SLSSNLKRTASNP-KVENEDEELSSSTESIDNSFSSPVRLAPERE--FIKSLMAIGKRLATLPTK 357
            ::.:|:....... |..|..|.|...::||..|||...:...|||  |...:.|:...:.:....
  Fly  1743 NMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKG 1807

Human   358 EQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFD 422
            .::....::.||.:  |:....:|| :..:..|:.:.::....:.|..|||||.
  Fly  1808 IERKNACLAALSRI--KVQGGCYLP-SNPEAMVLDIDYSSGTPMQSAAKAPYLA----------- 1858

Human   423 TTSVPARIPENRIRSTRSVENLPECGITH-EQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEV 486
                       |.|..|       ||||. |.||...|..||
  Fly  1859 -----------RFRVYR-------CGITELETRAMEVSNNPN----------------------- 1882

Human   487 HTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQE 551
                             |||          |.:..|.                      .|.||
  Fly  1883 -----------------SQE----------DAKMTLG----------------------VESWQ- 1897

Human   552 KVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVIS 616
                                :.|.|.|||:||::||.||:...::|::|..:.|::.||:::..:
  Fly  1898 --------------------AAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATA 1942

Human   617 ADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQV 681
            ...|:||.|.||.|..|:.:|:...|.:||..::|..:::.|.:|:.|||:|.|.|.|:.||||:
  Fly  1943 PGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQI 2007

Human   682 KDRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LDGDMFNYYKML 744
            ||||||||::|.:||||||||||:..||| .|:|||.. .|||.|.|.:||| :|...|.::..|
  Fly  2008 KDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPD-MKLTDEMVMIMGGKMDSPAFKWFCEL 2071

Human   745 MLQGLIAARKHMDKVVQIVEIMQQGCRRCSGSSPSGPMMTVAQVICSQLPCFHGSSTIRNLKERF 809
            .:|..:|.|.:.|.:|.:|.:|                      :.:.||||.| .||..||:||
  Fly  2072 CVQAFLAVRPYQDAIVSLVSLM----------------------LDTGLPCFRG-QTINLLKQRF 2113

Human   810 HMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGI 848
            ..:...::....:..::..|.::..|:.||..||..|.|
  Fly  2114 VATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQI 2152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PI4KB	XP_011507936.1	PI4KB_NTD	14..78	CDD:412074	8/36 (22%)
		PI4Kc_III_beta	541..849	CDD:270712	108/310 (35%)
Pi4KIIIalpha	NP_001259191.1	PI4K_N	386..1571	CDD:437106	24/149 (16%)
		PI4Ka	1600..1775	CDD:238443	34/177 (19%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	133/463 (29%)