Protein Alignment PI4KB and pik1

DIOPT Version :9

• Sequence 1: XP_011507936.1
• Gene: PI4KB / 5298
• HGNCID: 8984
• Length: 849
• Species: Homo sapiens
• Sequence 2: NP_594842.1
• Gene: pik1 / 2541887
• PomBaseID: SPAC22E12.16c
• Length: 851
• Species: Schizosaccharomyces pombe
• Alignment Length: 890
• Identity: 251/890 - (28%)
• Similarity: 410/890 - (46%)
• Gaps: 218/890 - (24%)

Human   134 NNSAKQSWLLRLFESKLFDISMAISYLYNSKEP---GVQAYIGNRLFCFRNEDVDFYLPQLLNMY 195
            :||..: .|||.|||..|...:.::||  |:.|   |:..::..:|..|..|:::|::|||:::.
pombe     4 SNSGNE-LLLRFFESAHFTSQLCVAYL--SRYPNNIGIHHFLCEKLATFPYEEIEFFIPQLIHLV 65

Human   196 IHMDEDVGDAIKPYIVHRCRQSINFSLQCALL----LGAYSSDMHISTQRHSRGTKLRKLI---- 252
            ::.|.: ..|::.:|:.:|.|    :.||||:    |.|:..|:.:  |.||...|:.|.:
pombe    66 LNKDSE-SVALEEFIISQCEQ----NTQCALITFWYLQAHMVDLGL--QPHSSCFKICKRLYNRI 123

Human   253 -----------------LSDELKPA-------------------------HRKRELPSLSP-APD 274
                             :|:.:.||                         .:.|:.|...| ..|
pombe   124 QILVFMSSSSLIQSQQKISENVTPALILSGIMLGGVCVPELLKKAGPIAIAQGRKAPRQDPDESD 188

Human   275 TGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEEL-------SSSTESID------- 325
            ..:.....|..|...|...| ||::::....|...:..:..||       ||:|.|||
pombe   189 VDVLRRLSTEPRYSLDVLRS-SLNNSIVEQHSEVSLRLKAPELTRTHSYQSSATLSIDEQRRVLR 252

Human   326 -NSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPT-----A 384
             |.|..      |.:|:.:|..|..||..:| ::.:...|.:||:|||:.|||.|.:|.     .
pombe   253 SNYFQQ------EIQFLFALQDISIRLIIVP-RQARLSSLRAELALLNNNLPADVNIPLLRSYHK 310

Human   385 GFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECE-NFDTTSVPARIPENRIRSTR--------- 439
            ...|.:||:...:|.:|||.::.||||.||||..| :|:..|...:....:|.|.:
pombe   311 EVSHKIVRIDPKEATILNSAERVPYLIMVEVLSGELSFEPQSKKNKAKVQKIVSHKNQRKRWFDL 375

Human   440 -------SVENLPECGITH-EQRAGSFSTVPNY-----DNDDEAWSVDDIGELQVELPEVHT--- 488
                   ::::..:..|:. |...|..|..|..     |....:.|....|.:.:::|..|.
pombe   376 TDVDPYTNLQDSTDNDISESESEGGDLSMSPLIKGLVPDTLSLSKSFSSFGNVSLQVPSSHRDTD 440

Human   489 -------------NSCDNISQFSVDSITSQESKEPVFI----AAGDIR----------------R 520
                         |.....|:.....||::.......:    |.|..|                :
pombe   441 VVLLSGRHSDSDGNGALKRSKIYASEITARMRAAATMLSQLDAEGSRRPKAETERIKNSIILDMQ 505

Human   521 RLSEQLAHTPTAF-----------------------KRDPEDPSAVALKEPWQEKVRRIREGSPY 562
            ||.|:..:.|:.:                       |.|.:||||...:|.|..|..|||:.|||
pombe   506 RLEEERLNEPSIYPVSVDISCAEDLRFGKETQKAERKGDRDDPSAATFQEDWYAKKERIRKSSPY 570

Human   563 GHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVN 627
            ||.|||.|:|||||.|.|||||..|.|::...|.:|.:.:..:|::..||||...:||:||.:.|
pombe   571 GHYPNWDLVSVIVKTGADLRQETFACQLIYAFQRVWLECKEKVWVRRMKILVTGDNSGLIETITN 635

Human   628 AVSIHQVKK------------------QSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCL 674
            |:|:|.:||                  ::.::|.|||:::.|...:..:..||.||:||...|.:
pombe   636 AISVHSIKKNLTKQLREAELAQGKIAGKNVVTLKDYFIKQFGDPNSSRYRQAQTNFLQSLVAYSI 700

Human   675 VCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFN 739
            :.||||:|||||||:|:|:|||||||||||:|:::|.|:|||::.||||.::::::    .|.|:
pombe   701 ISYLLQLKDRHNGNVLIDSEGHIIHIDFGFLLTNTPGNVGFESAPFKLTADYLEIL----DDRFD 761

Human   740 YYKMLMLQGLIAARKHMDKVVQIVEIMQQGCRRCSGSSPSGPMMTVAQVICSQLPCFH-GSSTIR 803
            .|:.||.....:.||:.|:::.:||:||..                     |.:|||. |.:|..
pombe   762 EYRSLMKAAFKSVRKNADQIILLVEVMQNN---------------------STMPCFRAGENTSA 805

Human   804 NLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGI 848
            .|.:||.:.:.:::....|:.::..:..|:.|:|||.||.:||||
pombe   806 QLLQRFQLQLGDKECDDFVDLLIQKANCSVWTRLYDLFQNITNGI 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PI4KB	XP_011507936.1	PI4Kc_III_beta	541..849	CDD:270712	126/327 (39%)
pik1	NP_594842.1	TEL1	<1..851	CDD:227365	251/890 (28%)
		PI3Ka	<29..103	CDD:294194	22/80 (28%)
		Pik1	110..160	CDD:288387	6/49 (12%)
		PI4Kc_III_beta	549..851	CDD:270712	126/327 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	181	1.000	Domainoid score	I910
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	350	1.000	Inparanoid score	I556
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003785
OrthoInspector	1	1.000	-	-		oto146052
orthoMCL	1	0.900	-	-		OOG6_101543
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1764
SonicParanoid	1	1.000	-	-		X2640
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850