DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PI4KB and CG30184

DIOPT Version :9

Sequence 1:	XP_011507936.1	Gene:	PI4KB / 5298	HGNCID:	8984	Length:	849	Species:	Homo sapiens
Sequence 2:	NP_726341.1	Gene:	CG30184 / 246506	FlyBaseID:	FBgn0050184	Length:	223	Species:	Drosophila melanogaster

Alignment Length:	240	Identity:	46/240 - (19%)
Similarity:	71/240 - (29%)	Gaps:	74/240 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   133 QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQ-------AYIGNRLFCFRNEDVDFYLPQ 190
            |..|.|..|.|......|..:...:.:.....|.||.       .|.|:.:.||.:....||..:
  Fly     2 QVRSKKPVWFLFKMMELLLSLGCCLVHWTCFMEEGVPHIFLLCGTYGGSVIICFISLIGAFYAER 66

Human   191 ---------------------LLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCA---LLLGAY 231
                                 ..|||:...|:......|.....||.:...:|...   |:...:
  Fly    67 PTMKHEALFGGILGGLHMVTVYANMYVATLEEFRTERWPSFYACCRDNAIVALYAGAIYLMHCTF 131

Human   232 SSDMHISTQRHSRGTKLRKLILSDELKPAH---------------------RKRELPSLSPAPDT 275
            :.|:..|   |||....:|:......:|..                     ..|.|.|..|:..:
  Fly   132 ALDLMFS---HSRSRANQKMHPQRSKRPLQLYFISRGAEAYLSRFWFFRRIAARMLTSAQPSEHS 193

Human   276 GLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSS 320
            |   .||....|:||:.|.                |.|:|.:.:|
  Fly   194 G---RKRQVSSSESDSDAK----------------EREEERIRNS 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
PI4KB	XP_011507936.1	PI4Kc_III_beta	541..849	CDD:270712
CG30184	NP_726341.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900