Protein Alignment PIK3R2 and pik3r2

DIOPT Version :10

• Sequence 1: NP_005018.2
• Gene: PIK3R2 / 5296
• HGNCID: 8980
• Length: 728
• Species: Homo sapiens
• Sequence 2: NP_997987.2
• Gene: pik3r2 / 404211
• ZFINID: ZDB-GENE-040309-1
• Length: 724
• Species: Danio rerio
• Alignment Length: 736
• Identity: 459/736 - (62%)
• Similarity: 564/736 - (76%)
• Gaps: 35/736 - (4%)

Human     5 EGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGD 69
            :|||||::|.:|::...|::|.|||:|.|.:.:|.:||:.||.|:.|:.:||:.|.||||:||||
Zfish     4 DGFQYRSIYSYRKDWEHDIDLEPGDILTVDKGSLLSLGIKEGDEQHPECIGWILGFNERTKQRGD 68

Human    70 FPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLP-----DLPEQFSPPDVAPPLLV 129
            ||||||:::|||.|:.|..:||..|||||.||   |||..:|.     ||.:||..|:.|||.|:
Zfish    69 FPGTYVQYVGPVKLSAPYCQPRSQRPLPAVPR---PEPTASLQVVPDLDLTKQFMHPETAPPNLI 130

Human   130 KLVEAIERTGLDSESHYRPELPAPRTDWSLS-----DVDQWDTAALADGIKSFLLALPAPLVTPE 189
            ||:||:||:|||..:.||......:.. |||     ||.|||..||::.:..:|..||||::.|.
Zfish   131 KLIEAVERSGLDCRTLYRTSASDNQRP-SLSELQDLDVGQWDIHALSEAVIRYLQDLPAPIIPPC 194

Human   190 ASAEARRALR-EAAGP-------VGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRAL 246
            ...:.:.|:: |:..|       :...|:.|.:||...|||.:|||||.:|...|...|..:..|
Zfish   195 VYTDLQAAVQLESDVPSVRRRELLQQVLDKPEVPLQNLLTLHYLLQHLDKVCQSAEQNGLDIYTL 259

Human   247 GATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKP 311
            |..|||||.|.|           ..|||....|||..||:||.|.:.|||..||||||||||||.
Zfish   260 GQIFGPLLFRGP-----------VSGSEEDEAFPAAAVERLLLERIWEQEPTPPALPPKPPKAKA 313

Human   312 ASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNK 376
            .::.:.| ||...|.:||||||||||||||||:||||||||||||||||:.||||||||||||||
Zfish   314 MASSVTN-GSDSLLSEAEWYWGDISREEVNEKMRDTPDGTFLVRDASSKVHGEYTLTLRKGGNNK 377

Human   377 LIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEA 441
            |||:|||.|.|||||||||.|||:||||||||||||||||||:.||:|||||||||:|||||:||
Zfish   378 LIKIFHRGGKYGFSEPLTFLSVVELINHYRHESLAQYNAKLDSHLLFPVSKYQQDQVVKEDSIEA 442

Human   442 VGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYL 506
            ||.||||||:|||:||||||.|||||||:||||||||||||||||||||||||.:|||:.|::.:
Zfish   443 VGEQLKVYHEQYQEKSREYDVLYEEYTRSSQELQMKRTAIEAFNETIKIFEEQCETQERLSRDSI 507

Human   507 ERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLR 571
            |:||||||:||::||..|||:||||:.|||:|:.|||..|:.||:|||||||.||||||||:|||
Zfish   508 EKFRREGNDKEIERIQSNSEKLKSRVTEIHDSKRKLELDLKRQATDNREIDKLMNSLKPDLIQLR 572

Human   572 KIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEML 636
            |:||||||||||||.||:|||||||||||:||.|:|::|:||..||:|.:||||.|.|:.||::|
Zfish   573 KLRDQYLVWLTQKGTRQRKINEWLGIKNESEDFYSLLDDDDDQAHHDECSWYVGDIKRSYAEDLL 637

Human   637 SGKRDGTFLIRES-SQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHAS 700
            .|||||||||||| :|:|.:||||||:|:.||||:|:||||||||||||||||||:|||||:|.|
Zfish   638 RGKRDGTFLIRESQTQKGSFACSVVVEGEIKHCVVYKTATGFGFAEPYNLYGSLKDLVLHYKHTS 702

Human   701 LVQHNDALTVTLAHPVRAPGP 721
            ||||||:|.||||:||.|..|
Zfish   703 LVQHNDSLNVTLAYPVLAQQP 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3R2	NP_005018.2	SH3_PI3K_p85beta	7..80	CDD:212842	37/72 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..117		18/40 (45%)
		RhoGAP	110..296	CDD:470621	76/203 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	254..279		6/24 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..320		15/24 (63%)
		SH2_nSH2_p85_like	322..432	CDD:198195	93/109 (85%)
		iSH2_PIK3R2	437..597	CDD:214019	123/159 (77%)
		SH2_cSH2_p85_like	615..717	CDD:198184	75/102 (74%)
pik3r2	NP_997987.2	SH3_PI3K_p85beta	6..79	CDD:212842	37/72 (51%)
		RhoGAP	113..298	CDD:470621	75/196 (38%)
		SH2_nSH2_p85_like	326..433	CDD:198195	93/106 (88%)
		iSH2_PIK3R2	438..598	CDD:214019	123/159 (77%)
		SH2_cSH2_p85_like	616..720	CDD:198184	76/103 (74%)