Protein Alignment PIK3R2 and Pik3r2

DIOPT Version :10

• Sequence 1: NP_005018.2
• Gene: PIK3R2 / 5296
• HGNCID: 8980
• Length: 728
• Species: Homo sapiens
• Sequence 2: NP_001411735.1
• Gene: Pik3r2 / 18709
• MGIID: 1098772
• Length: 754
• Species: Mus musculus
• Alignment Length: 760
• Identity: 647/760 - (85%)
• Similarity: 676/760 - (88%)
• Gaps: 38/760 - (5%)

Human     1 MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTR 65
            |||.|||||||:|||||||||||||||||:|||||.||||||||:||||||.:||||||.|||||
Mouse     1 MAGAEGFQYRAVYPFRRERPEDLELLPGDLLVVSRVALQALGVADGGERCPHNVGWMPGFNERTR 65

Human    66 QRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEP----------------------- 107
            |||||||||||||||||||||||||||||||||||.||:.|.
Mouse    66 QRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPLDGSSESECWSDGCPLPHLALSSYRPSCPP 130

Human   108 ---------GLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVD 163
                     |..||||.|||||||.|||:|||||||||:..||||.:.:|||||.||||||||::
Mouse   131 LSLGLQIPCGHILPDLAEQFSPPDPAPPILVKLVEAIEQAELDSECYSKPELPATRTDWSLSDLE 195

Human   164 QWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQH 228
            |||..||.|.:|.|||||||.:|||||:|||.|||||.|||||..|||||||||:||||||||||
Mouse   196 QWDRTALYDAVKGFLLALPAAVVTPEAAAEAYRALREVAGPVGLVLEPPTLPLHQALTLRFLLQH 260

Human   229 LGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLE 293
            |||||.|||:...||.||.:.|||||||.      ||.||..|||||.||||.||:|:|:|||:|
Mouse   261 LGRVARRAPSPDTAVHALASAFGPLLLRI------PPSGGEGDGSEPVPDFPVLLLERLVQEHVE 319

Human   294 EQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDAS 358
            ||:.|||||||||.|||||.|.|||||||||||||||||||||||||||:|||||||||||||||
Mouse   320 EQDAAPPALPPKPSKAKPAPTALANGGSPPSLQDAEWYWGDISREEVNERLRDTPDGTFLVRDAS 384

Human   359 SKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLY 423
            |||||||||||||||||||||||||||||||||||||||||:||:||||||||||||||||||||
Mouse   385 SKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVELISHYRHESLAQYNAKLDTRLLY 449

Human   424 PVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETI 488
            |||||||||:|||||:|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   450 PVSKYQQDQVVKEDSIEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETI 514

Human   489 KIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDN 553
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||
Mouse   515 KIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQDLRAQASDN 579

Human   554 REIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHE 618
            |||||||||||||||||||||||||||||||||||:||||||||||||||||:||||||.|||||
Mouse   580 REIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQRKINEWLGIKNETEDQYSLMEDEDALPHHE 644

Human   619 ERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPY 683
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   645 ERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPY 709

Human   684 NLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR 728
            |||||||||||||||||||||||||||||||||||||||||.|||
Mouse   710 NLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPSAAR 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3R2	NP_005018.2	SH3_PI3K_p85beta	7..80	CDD:212842	65/72 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	81..117		28/67 (42%)
		RhoGAP	110..296	CDD:470621	132/185 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	254..279		13/24 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..320		19/24 (79%)
		SH2_nSH2_p85_like	322..432	CDD:198195	106/109 (97%)
		iSH2_PIK3R2	437..597	CDD:214019	156/159 (98%)
		SH2_cSH2_p85_like	615..717	CDD:198184	101/101 (100%)
Pik3r2	NP_001411735.1	SH3_PI3K_p85beta	7..80	CDD:212842	65/72 (90%)
		RhoGAP	143..321	CDD:470621	131/183 (72%)
		SH2_nSH2_p85_like	348..458	CDD:198195	106/109 (97%)
		iSH2_PIK3R2	463..623	CDD:214019	156/159 (98%)
		SH2_cSH2_p85_like	641..744	CDD:198184	102/102 (100%)