Protein Alignment PIK3CG and Pi3K92E

DIOPT Version :10

• Sequence 1: NP_002640.2
• Gene: PIK3CG / 5294
• HGNCID: 8978
• Length: 1102
• Species: Homo sapiens
• Sequence 2: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 1061
• Identity: 336/1061 - (31%)
• Similarity: 533/1061 - (50%)
• Gaps: 155/1061 - (14%)

Human   112 KYQV--VQTLDCLRYWKATHR----SP--GQIHLVQRHPPSEESQAFQ--RQLTALIGYDVTDVS 166
            :|||  :.|.:...|...|.|    .|  |.:.|.:|...:..|..::  :.:..:|| ...|.:
  Fly    92 EYQVYGISTFNIEPYTDETKRLSEVQPYFGILSLGERTDTTSFSSDYELTKMVNGMIG-TTFDHN 155

Human   167 NVHD---------------DELEFTRRGLVTPRMAEVASRDPKLYAMHP--WVTSKPLPEYLWKK 214
            ..|.               |.:|..|......:         :|...||  ...|..:||.:.::
  Fly   156 RTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQ---------RLLYEHPLRLANSTKMPELIRER 211

Human   215 IANNCIFIVI--HRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGR 277
            .......||:  ....::.|:.|:..|||.::.:|...||.:.:..|    :....|::|:|.||
  Fly   212 HPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKM----NDRTSDYILKVSGR 272

Human   278 DEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQL--- 339
            ||||:|:.|:..|.:::..|.:....:|||.:       ..|.|.:        :..::||.
  Fly   273 DEYLLGDYPLIQFLYIQEMLSDSAVPNVVLQS-------VYRLESY--------INHHNEQAMVT 322

Human   340 --------TIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQ 396
                    |:|  .|:|:  .||||....|::.:..|......:...|.|.|...:.||.:.||.
  Fly   323 KRPLPKKRTVH--LHKSI--SSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCA 383

Human   397 RRTSPKP---FTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKV 458
            :|::..|   |...:..::.::|.|::::||:...|.:.|:      ..:|.|....||.:| .:
  Fly   384 QRSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIF------EVTKMSRSKKSSNNK-DI 441

Human   459 QL---------LYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSA--------- 505
            .|         |.:||..:.||:.:||.|.:.|:.|..           ||.:.|.
  Fly   442 ALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTY-----------ADDIQSVEVFHPLGTI 495

Human   506 -TNPDKENSMSISI-LLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLR----------KQLEAI 558
             .||.||....:.: .|.:....:..|..:.......||   |..|:|:          |:|:.:
  Fly   496 EPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADR---EQVNRLQRQLAGPEKPIKELKEL 557

Human   559 IAT----DPLNPLTAEDKELLWHFRYESLKH-PKAYPKLFSSVKWGQQEIVAKTYQLLARREVWD 618
            :|.    |.:..:..:|:..:|..|.:.|:. |:....|...|.|.:::.||..:.||.:   |
  Fly   558 MANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQ---W- 618

Human   619 QSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLK 683
             ..:.:..:::|||..:.|..||..|::.|..|:|:|:|.||||||||:|.|.|.:|.|..|||:
  Fly   619 -PLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLE 682

Human   684 RGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRGC--GTAMLHDFTQQVQVIEMLQKVT 746
            |.|||:||||:.||.||||: |:...|.||.::||.||:||  ..|.|.   :|:.|:|.|::.:
  Fly   683 RALRNQRIGHYFFWHLRSEM-QTPSMQTRFGLLLEVYLKGCKHHVAPLR---KQLHVLEKLKQGS 743

Human   747 LDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPL 811
            |..|..|.||      |.:.|:..|.:.:||.:.::.:.|.:|..:...:..::||||.||.:||
  Fly   744 LIAKKGSKEK------VKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKVMDSKMRPL 802

Human   812 WLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKI 876
            |:.|:.||..|   ..:.||||:|||||||||.||:||:|:.:|:.:.:|..:..|.|||....:
  Fly   803 WVVFENADVNA---SDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSL 864

Human   877 GMIEIVKDATTIAKIQ--QSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVAT 939
            ||||:|:.|.|||.||  :.....|..||...|..||||.:...:|...|:..|..|||||||||
  Fly   865 GMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVAT 929

Human   940 FVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTS-GKKTS 1003
            :|||:.|||:||||:...|.|||||||||||::|..||:.:||||||||.||::|:... ..:.|
  Fly   930 YVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRES 994

Human  1004 PHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYF 1068
            ..|..||::|.:|:|.||.|..|::.|||||:.||:|:|:|::|::|:|:.|.:...||.|:::|
  Fly   995 KEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHF 1059

Human  1069 LDQIEVCRDKGWTVQFNWFLH 1089
            ..:........|....||..|
  Fly  1060 RAKFSEALANSWKTSLNWASH 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CG	NP_002640.2	PIK3CG_ABD	1..192	CDD:466155	19/104 (18%)
		PI3K_rbd	203..312	CDD:197540	30/110 (27%)
		C2_PI3K_class_I_gamma	350..527	CDD:176044	46/199 (23%)
		PI3Ka_I	549..725	CDD:238444	71/192 (37%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	154/364 (42%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	803..809		4/5 (80%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	943..951		4/7 (57%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	962..988		18/25 (72%)
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589	11/39 (28%)
		PI3K_rbd	200..307	CDD:197540	30/117 (26%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	46/195 (24%)
		PI3Ka_I	552..723	CDD:238444	68/176 (39%)
		PI3Kc_I	727..1084	CDD:270709	155/366 (42%)