DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIK3CG and pik3cg

DIOPT Version :9

Sequence 1:	NP_001269355.1	Gene:	PIK3CG / 5294	HGNCID:	8978	Length:	1102	Species:	Homo sapiens
Sequence 2:	XP_021330656.1	Gene:	pik3cg / 406598	ZFINID:	ZDB-GENE-040426-2532	Length:	1113	Species:	Danio rerio

Alignment Length:	1095	Identity:	789/1095 - (72%)
Similarity:	923/1095 - (84%)	Gaps:	8/1095 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     9 PVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHGNVEQMKAQ 73
            |||.||:|.|||||||..::|::: |||.|.:||||||:.:..|:.:|..|.|.|:..|||:|.|
Zfish    26 PVVRREENKRRRRRMKAFTSASAV-SMEHIAVEFVLPTTNKNSKTLDTLQLDVTGNWTVEQVKVQ 89

Human    74 VWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHLV 138
            :|.||:.:.:..:||.:..|.:.:|||||||.|||||||.||.|||||:|||||..:..|:||||
Zfish    90 LWHRAVTSKLCPEFYQKYSPDYCILLYQKKGNWYEIYDKQQVFQTLDCIRYWKALRKDVGKIHLV 154

Human   139 QRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYAMHPWVT 203
            .|..|:|:|..:||.|..||||||||||||||||||||||.|:|||..|::.|||.||:|.||:|
Zfish   155 VRQQPAEDSLQYQRFLNHLIGYDVTDVSNVHDDELEFTRRKLLTPRKIELSDRDPNLYSMDPWMT 219

Human   204 SKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQ 268
            :.|:||||..||:||.|.:|||:.|||||||||.||||..:|||||.|:..|::|:.|.|..||.
Zfish   220 TTPMPEYLLSKISNNHILMVIHKETTSQTIKVSIDDTPVQVLQSFFAKITNKRALLGISEDVSES 284

Human   269 DFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVT 333
            |||||||||:|||.|...||:|.|:|.|||||||||:||:.||:|..|.|:||:|..|||||||.
Zfish   285 DFVLRVCGREEYLYGNNAIKDFHWIRQCLKNGEEIHLVLEHPPNPEQDVVQKEDWSQVDDCTGVA 349

Human   334 GYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHGQQVLCQRR 398
            |.||||||..||||.|||:|||||:|||||||.||||||||||::|.|||||:|.||||:|.|.|
Zfish   350 GTHEQLTITEKDHEKVFTISLWDCNRKFRVKILGIDIPVLPRNSELIVFVEASIFHGQQLLAQER 414

Human   399 TSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKASAESPSSESKGKVQLLYY 463
            ||.|||||||:||.||||:||||||||||.|:||:.||||...:||      .:|.|.|.:||||
Zfish   415 TSSKPFTEEVIWNTWLEFNIKIKDLPKGARLSLQVSCGKAQTQTSK------ETECKNKSRLLYY 473

Human   464 VNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIA 528
            |||||:|||.|||:||::||||::..|.||..|.|||||||||||||.|||:::||||.||:|:|
Zfish   474 VNLLLVDHRSLLRQGEFILHMWKMPEKSEDNSSVNADKLTSATNPDKNNSMAVAILLDKYCYPVA 538

Human   529 LPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLF 593
            |||.:.:||.||:|.:.||||.||||.|.|||||||:|||:||||||||||.|.::.||||||..
Zfish   539 LPKSKDSPDIEGERGQREMPNHLRKQFEQIIATDPLHPLTSEDKELLWHFRQECMRDPKAYPKFL 603

Human   594 SSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLH 658
            ||||||:||.||.|:.||.|..:||:|.|||||.:|||||:|||||||.|||:|||:|.|||||.
Zfish   604 SSVKWGKQEAVAITHYLLERSTIWDRSVLDVGLVLQLLDCHFSDENVRTIAVRKLETLGDDDVLR 668

Human   659 YLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAYLRG 723
            ||||||||||||||||||||||||||.||:||||||||||||||||||.|||||:||||||||||
Zfish   669 YLLQLVQAVKFEPYHDSALARFLLKRALRSKRIGHFLFWFLRSEIAQSMHYQQRYAVILEAYLRG 733

Human   724 CGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYD 788
            ||..||.||.:||::.|.||||..:||.:||||||:|:||:.||:||||.||...||:||:||||
Zfish   734 CGEEMLQDFRKQVEITEALQKVAREIKQISAEKYDISAQVVFQLRQKLEGLQVLGLPDSFKVPYD 798

Human   789 PGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQDMLILQILRIMES 853
            |||:||||.||:|||||||||||||:||.||||.||::|||||||.||||||||||||||.||||
Zfish   799 PGLRAGALVIEQCKVMASKKKPLWLQFKRADPTTLSSDTIGIIFKDGDDLRQDMLILQILLIMES 863

Human   854 IWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTE 918
            |||.|||||.||||||||||:|||||||||||||||.|||||||||||||||:|:.||:||...|
Zfish   864 IWELESLDLSLLPYGCISTGNKIGMIEIVKDATTIANIQQSTVGNTGAFKDEILSQWLREKCVNE 928

Human   919 EKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERV 983
            :|.|.||:|||:||.||||||:||||||||||||||||||||||||||||||||||||||:||||
Zfish   929 DKHQQAVDRFVFSCGGYCVATYVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGISKERV 993

Human   984 PFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDI 1048
            |||||||||::|||:|||:||:|.:||::|:||||||||||||||||||||||||||||||||||
Zfish   994 PFVLTPDFLYLMGTTGKKSSPNFLQFQNVCLKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDI 1058

Human  1049 EYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG-EKHSA 1102
            ||||:|||||::|::||::||||||:||||||||||||||||||||||| ||.||
Zfish  1059 EYIREALTVGRSEDEAKQHFLDQIEICRDKGWTVQFNWFLHLVLGIKQGVEKRSA 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CG	NP_001269355.1	PI3K_rbd	203..312	CDD:197540	69/108 (64%)
		C2_PI3K_class_I_gamma	350..527	CDD:176044	122/176 (69%)
		PI3Ka_I	549..725	CDD:238444	140/175 (80%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	295/365 (81%)
pik3cg	XP_021330656.1	PI3K_rbd	221..327	CDD:307097	67/105 (64%)
		C2_PI3K_class_I_gamma	366..537	CDD:176044	122/176 (69%)
		PI3Ka_I	559..735	CDD:238444	140/175 (80%)
		PI3Kc_IB_gamma	739..1105	CDD:270627	295/365 (81%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194327520
Domainoid	1	1.000	383	1.000	Domainoid score	I5043
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1617	1.000	Inparanoid score	I772
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG44892
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0011353
OrthoInspector	1	1.000	-	-		oto49910
orthoMCL	1	0.900	-	-		OOG6_100986
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9209
SonicParanoid	1	1.000	-	-		X531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300