Protein Alignment PIK3CG and pik3

DIOPT Version :10

• Sequence 1: NP_002640.2
• Gene: PIK3CG / 5294
• HGNCID: 8978
• Length: 1102
• Species: Homo sapiens
• Sequence 2: NP_594699.1
• Gene: pik3 / 2543444
• PomBaseID: SPAC458.05
• Length: 801
• Species: Schizosaccharomyces pombe
• Alignment Length: 895
• Identity: 237/895 - (26%)
• Similarity: 398/895 - (44%)
• Gaps: 216/895 - (24%)

Human   232 TIKVSPDDTPGAILQSFFTKMAKKKSLMDIPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHC 296
            ||::...:..|:::|..|......|||:
pombe    37 TIQLFSGNESGSLMQKCFVSKIPNKSLL------------------------------------- 64

Human   297 LKNGEEIHVVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKF 361
                         |.:  |.::...||  :|  .|||  ..:|:::.|     |.||.|
pombe    65 -------------PTE--LSKISTHEW--LD--FGVT--VSELSLNAK-----FVVSAW------ 97

Human   362 RVKIRGIDIPVLPRNTDLTVFVEANI--QHGQQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLP 424
            :......::......|...:|.|.|:  |..|::..|.....|.::..   ::.||   ::|::.
pombe    98 KPSFNDEEVYEFVGCTTYRLFDENNLLRQGLQKIPLQTSKEIKKYSPT---SLELE---QVKEIN 156

Human   425 K--GALLNLQIYCGKAPALS-----SKASAESPSSESKGKVQL-LYYVNLLLIDHRFLLRRGEYV 481
            :  |.||.||:  |..|:::     |....:...|:....|.: :.|::.|......:.:|..|
pombe   157 RLDGLLLKLQL--GDVPSVNWLDDISFGKIKDFRSKHMSLVTIPILYLDFLQFSFPVVFQRSYY- 218

Human   482 LHMWQISGKGEDQGSFNADKLTSATNPDKEN-----SMSISILLDNYCHPIALPKHQPTPDPEGD 541
                                      |..||     |..:.:.||:   |..| ||:..
pombe   219 --------------------------PKSENRVYYSSFDLELNLDS---PAEL-KHRRL------ 247

Human   542 RVRAE---------MPN-QLRKQLEAIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSV 596
             ||::         .|| ::||:||:|::..|...|:.|:|:|:|.||:...::.||..|...||
pombe   248 -VRSQRNGPLDKDLKPNSKIRKELESILSYPPSEELSLEEKDLIWKFRFYLTRNKKAMTKFLKSV 311

Human   597 KWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLL 661
            .|.....|.:...||   :.|.:  :|:...::||..:|....|||.||.:||:..::::|.|||
pombe   312 VWTDSSEVNQALSLL---DSWTE--IDIDDALELLSPSFVHPKVRAYAVSRLETASNEELLLYLL 371

Human   662 QLVQAVKF-------EPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEA 719
            |||||:::       |.:..|.||.||:.|.:.:..||:.|:|:|..|| :.....:.|:.::..
pombe   372 QLVQALRYDNPISSDERFQPSPLALFLVNRAISSPSIGNDLYWYLVVEI-EDEPVSKLFSSVMFL 435

Human   720 YLRGC-----GTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLEN-----L 774
            :.:..     |..:....:.|.:.:|.|.:::..::|....:.    :.|..||..||:     |
pombe   436 FQKELSKSVEGRLIRETLSAQAKFVEKLLRISKSVQSFRGTRL----KKIEYLKVLLEDHKYHLL 496

Human   775 QNSQLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLR 839
            ....||    :|.||.:....:..:.|.|..|..:||.|.|||.|     .....||||:|||||
pombe   497 DFHALP----LPLDPSVNIVGIIPDACTVFKSTMQPLRLLFKCQD-----GSKYPIIFKNGDDLR 552

Human   840 QDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKD---ATTIAKIQQSTVGNTGA 901
            ||.|::|||.:|:.:.:.|.|||.|.||..::||...|.::.|..   ||.:|:...|.:.
pombe   553 QDQLVIQILTLMDKLLKKEKLDLHLKPYRILATGPTHGAVQFVPSKTLATILAEYHGSVLA---- 613

Human   902 FKDEVLNHWLKEKSPTEEKFQA-------AVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGN 959
                    :|:|.:|.:....|       |::.:|.|||||||.|::||:||||.||::||:.|:
pombe   614 --------YLRENNPDDGLNSANYGIDPVAMDNYVRSCAGYCVITYLLGVGDRHLDNLLITKDGH 670

Human   960 LFHIDFGHILGN----YKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLAL 1020
            .||.|||:|||.    :...:.::||.|..:            |...||.:|:|:..|...:.||
pombe   671 FFHADFGYILGRDPKLFSPAMKLSKEMVEGM------------GGYNSPFYQQFKSYCYTTFTAL 723

Human  1021 RHHTNLLIILFSMMLMTGMPQLT-SKEDIEY-IRDALTVGKNEEDAKKYF 1068
            |..:||::.|||:|:...:|.:. .||.:.| :::...:..:|.||.|||
pombe   724 RKSSNLILNLFSLMVDANIPDIKFDKEKVVYKVKERFCLQMSESDAIKYF 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CG	NP_002640.2	PIK3CG_ABD	1..192	CDD:466155
		PI3K_rbd	203..312	CDD:197540	9/79 (11%)
		C2_PI3K_class_I_gamma	350..527	CDD:176044	35/191 (18%)
		PI3Ka_I	549..725	CDD:238444	59/188 (31%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	117/361 (32%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	803..809		2/5 (40%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	943..951		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	962..988		10/29 (34%)
pik3	NP_594699.1	TEL1	<1..801	CDD:227365	237/895 (26%)
		PI3Kc_III	450..797	CDD:270628	117/361 (32%)