Protein Alignment PIK3CG and age-1

DIOPT Version :10

• Sequence 1: NP_002640.2
• Gene: PIK3CG / 5294
• HGNCID: 8978
• Length: 1102
• Species: Homo sapiens
• Sequence 2: NP_496462.2
• Gene: age-1 / 174762
• WormBaseID: WBGene00000090
• Length: 1182
• Species: Caenorhabditis elegans
• Alignment Length: 1178
• Identity: 316/1178 - (26%)
• Similarity: 542/1178 - (46%)
• Gaps: 255/1178 - (21%)

Human    75 WLRA-LETSV---AADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQI 135
            |..| :.||:   .:||.|:|    |.|:...|...|.:..:..|.:.|:          :.|:|
 Worm    96 WFLANVRTSLEIKLSDFKHQL----FELIAPMKWGTYSVKPQDYVFRQLN----------NFGEI 146

Human   136 HLV--QRHPPSE-------------------ESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRG 179
            .::  ...|.|:                   ..:.....::..:||.:..:....|:||...|..
 Worm   147 EVIFNDDQPLSKLELHGTFPMLFLYQPDGINRDKELMSDISHCLGYSLDKLEESLDEELRQFRAS 211

Human   180 LVTPRMAEVASRDPKLYAMHPWVTSK----------------PLPEYL----------------- 211
            |                    |..:|                |..:||
 Worm   212 L--------------------WARTKKTCLTRGLEGTSHYAFPEEQYLCVGESCPKDLESKVKAA 256

Human   212 -------WKK----IANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMDI--PE 263
                   |:|    |...|      .......|:.:|::||.::|.:|..:|.|    :|:  .:
 Worm   257 KLSYQMFWRKRKAEINGVC------EKMMKIQIEFNPNETPKSLLHTFLYEMRK----LDVYDTD 311

Human   264 SQSEQDFVLRVCGRDEYLVG-ETPIKNFQWVRHCLKN--------GEEIHVVLD-TPPDPALDE- 317
            ..:::.:.|::.||..::.. :..:.::..||..|::        ..:..|:.| ..|.|..:.
 Worm   312 DPADEGWFLQLAGRTTFVTNPDVKLTSYDGVRSELESYRCPGFVVRRQSLVLKDYCRPKPLYEPH 376

Human   318 -VRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFT----------VSLWDCDRKFRVK---IRGI 368
             ||..|..|..|...|:  .:......|:.:.|.|          |||||.|....::   |.|.
 Worm   377 YVRAHERKLALDVLSVS--IDSTPKQSKNSDMVMTDFRPTASLKQVSLWDLDANLMIRPVNISGF 439

Human   369 DIPVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFTEEVLWNVWL-EFSIKIKDLPKGALLNLQ 432
            |.|.   :.|:.|.:|.::..|...|..:.|: |...:...||..: .|.:.:||:|..|:|:::
 Worm   440 DFPA---DVDMYVRIEFSVYVGTLTLASKSTT-KVNAQFAKWNKEMYTFDLYMKDMPPSAVLSIR 500

Human   433 IYCGKAPALSSKASAESPSSESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSF 497
            :..||....|.:..              :.:||:.|.|.|..||:|:::.|:|
 Worm   501 VLYGKVKLKSEEFE--------------VGWVNMSLTDWRDELRQGQFLFHLW------------ 539

Human   498 NADKLTSATNPDKEN------SMSISILLDNYCHPIALP---------KHQ----PTPDPEGDRV 543
             |.:.|:..:...||      :.:::|.:.:|...:.:|         ||:    .|.:..||..
 Worm   540 -APEPTANRSRIGENGARIGTNAAVTIEISSYGGRVRMPSQGQYTYLVKHRSTWTETLNIMGDDY 603

Human   544 RAEMPNQLRKQLEAIIATDPLNPLTAEDKE---LLWHFRYESLKHPKAYPKLFS-SVKWGQQEIV 604
            .:.:.:...|:|:.::.......:..||::   .:|. ||...:.|.....|.. :..|..:|..
 Worm   604 ESCIRDPGYKKLQMLVKKHESGIVLEEDEQRHVWMWR-RYIQKQEPDLLIVLSELAFVWTDRENF 667

Human   605 AKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLH-YLLQLVQAVK 668
            ::.|.:|   |.|...::...||  ||....:|..:|..||:||.........| ::|.|:||:|
 Worm   668 SELYVML---EKWKPPSVAAALT--LLGKRCTDRVIRKFAVEKLNEQLSPVTFHLFILPLIQALK 727

Human   669 FEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIA-------QSRHYQQRFAVILEAYLRGCGT 726
            :||...|.:...||.|.|.:.||||.|||.||:|||       :|..| :|.::::|||||| ..
 Worm   728 YEPRAQSEVGMMLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEY-RRISLLMEAYLRG-NE 790

Human   727 AMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFRVPYDPGL 791
            ..:...|:||.:::.|.:::..:|.:..   ||::.   :|:.:|.::.:..  |:...|.||..
 Worm   791 EHIKIITRQVDMVDELTRISTLVKGMPK---DVATM---KLRDELRSISHKM--ENMDSPLDPVY 847

Human   792 KAGALAIEKCKVMASKKKPLWLEFKCADPTA-LSNETIGIIFKHGDDLRQDMLILQILRIMESIW 855
            |.|.:.|:|..|:.|.|:||.|.:|..:|.: |......:|||:|||||||||:||:|.:|::||
 Worm   848 KLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDMLVLQVLEVMDNIW 912

Human   856 ETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQST-VGNTG--AFKDEVLNHWLKE---- 913
            :..::|.||.||..:..|:.||:||:|.:..||.:||..| ..||.  :.....:|.|:::
 Worm   913 KAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQCGI 977

Human   914 ------------KSPTEEKF---QA------AVERFVYSCAGYCVATFVLGIGDRHNDNIMITET 957
                        |:|.|:|.   ||      :|:||:|||.||.|||:::||.|||:||:|:||.
 Worm   978 EDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLMLTED 1042

Human   958 GNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKK---TSPHFQKFQDICVKAYLA 1019
            |..||||||||||:.|:.|||.::|.||:||..|:.|: .|||.   .|...|||:.:||:||..
 Worm  1043 GKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTVI-RSGKSVDGNSHELQKFKTLCVEAYEV 1106

Human  1020 LRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTV-GKNEEDAKKYFLDQIEVCRDKGWTVQ 1083
            :.::.:|.:.||::||...:|:|::|.|:::::..|.. |:::|:|:|:|....|...:..|:.:
 Worm  1107 MWNNRDLFVSLFTLMLGMELPELSTKADLDHLKKTLFCNGESKEEARKFFAGIYEEAFNGSWSTK 1171

Human  1084 FNWFLHLV 1091
            .||..|.|
 Worm  1172 TNWLFHAV 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CG	NP_002640.2	PIK3CG_ABD	1..192	CDD:466155	25/141 (18%)
		PI3K_rbd	203..312	CDD:197540	25/164 (15%)
		C2_PI3K_class_I_gamma	350..527	CDD:176044	45/196 (23%)
		PI3Ka_I	549..725	CDD:238444	59/187 (32%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	145/396 (37%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	803..809		2/5 (40%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	943..951		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	962..988		16/25 (64%)
age-1	NP_496462.2	PI3K_p85B	98..177	CDD:197539	17/92 (18%)
		PI3K_rbd	241..360	CDD:197540	19/128 (15%)
		C2_PI3K_like	420..574	CDD:176026	44/184 (24%)
		PI3Ka	606..798	CDD:214537	59/199 (30%)
		Protein Kinases, catalytic domain	793..1181	CDD:473864	145/396 (37%)