Protein Alignment PIK3CG and pik3cg

DIOPT Version :10

• Sequence 1: NP_002640.2
• Gene: PIK3CG / 5294
• HGNCID: 8978
• Length: 1102
• Species: Homo sapiens
• Sequence 2: XP_012814080.1
• Gene: pik3cg / 100158519
• XenbaseID: XB-GENE-1011009
• Length: 1126
• Species: Xenopus tropicalis
• Alignment Length: 1110
• Identity: 881/1110 - (79%)
• Similarity: 985/1110 - (88%)
• Gaps: 8/1110 - (0%)

Human     1 MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQRKCKSPETALLHVAGHG 65
            |||::|:||||||::|.||||||:|.||.:::..||.|||||:||||.|..|..||.||.|||:.
 Frog    17 MELDSYEQPVVLRDENQRRRRRMRPHSATSNMFPMEQIPIEFILPTSNRCSKVQETMLLEVAGNC 81

Human    66 NVEQMKAQVWLRALETSVAADFYHRLGPHHFLLLYQKKGQWYEIYDKYQVVQTLDCLRYWKATHR 130
            :|||||||:|:.|:|.|..:|||.||.|..|||.|||||||||||||:||:|||||:.|||...:
 Frog    82 SVEQMKAQIWMHAIEKSHNSDFYQRLTPDQFLLQYQKKGQWYEIYDKHQVIQTLDCIMYWKVLQK 146

Human   131 SPGQIHLVQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKL 195
            :.|:||:||:....||...:|:.|..||||||||||||||||||||||.||||||.|::.||.:|
 Frog   147 TVGKIHIVQKEKIPEEMIEYQKTLNYLIGYDVTDVSNVHDDELEFTRRRLVTPRMIELSRRDARL 211

Human   196 YAMHPWVTSKPLPEYLWKKIANNCIFIVIHRSTTSQTIKVSPDDTPGAILQSFFTKMAKKKSLMD 260
            |:|.||||.|.|||||.::|.:|.|||:||:..||.||:||.||||..||.||||||||||||:|
 Frog   212 YSMDPWVTCKSLPEYLCQRIISNSIFIIIHKGMTSHTIRVSIDDTPDVILHSFFTKMAKKKSLLD 276

Human   261 IPESQSEQDFVLRVCGRDEYLVGETPIKNFQWVRHCLKNGEEIHVVLDTPPDPALDEVRKEEWPL 325
            |.|..||.||||||||||||::|..|||:|.|:|.|:|||:|||:||:.||||.:|||:||:|||
 Frog   277 ISEENSELDFVLRVCGRDEYIIGNAPIKDFHWIRQCIKNGQEIHLVLEKPPDPLMDEVQKEQWPL 341

Human   326 VDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRKFRVKIRGIDIPVLPRNTDLTVFVEANIQHG 390
            ||||||||||||||||.|||||.:||:|||||:|||||||.||||||||:||:|..|||||||||
 Frog   342 VDDCTGVTGYHEQLTIEGKDHEKIFTISLWDCNRKFRVKIIGIDIPVLPKNTELIAFVEANIQHG 406

Human   391 QQVLCQRRTSPKPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYCGKAPALSSKA---SAESPSS 452
            ||||.||||:.||||||||||.||||.||||||||||||||||:|||||..|:|:   |.||.:|
 Frog   407 QQVLSQRRTTCKPFTEEVLWNSWLEFDIKIKDLPKGALLNLQIFCGKAPTASNKSIVQSPESTAS 471

Human   453 ESKGKVQLLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKENSMSIS 517
            :||.|.||||||||||||||||||:||||||||:|.||||:|||.||||||||||||||.||:||
 Frog   472 DSKCKNQLLYYVNLLLIDHRFLLRQGEYVLHMWKIPGKGEEQGSINADKLTSATNPDKETSMAIS 536

Human   518 ILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYES 582
            |.||.||||:|||||:...|||.:|.|.|||||||||||.|||||||:|||.||||||||||.|.
 Frog   537 ISLDKYCHPVALPKHKLVCDPELERPRTEMPNQLRKQLEEIIATDPLHPLTPEDKELLWHFRSEI 601

Human   583 LKHPKAYPKLFSSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQK 647
            :|||:|||||.|||||||||:||||||||::||.||..:||||||:||||||||||||||:||||
 Frog   602 VKHPEAYPKLLSSVKWGQQEMVAKTYQLLSKREAWDDCSLDVGLTIQLLDCNFSDENVRAMAVQK 666

Human   648 LESLEDDDVLHYLLQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQR 712
            ||||:|||||||||||||||||||||||||:||||||.|::||||||||||||||||||.|||||
 Frog   667 LESLQDDDVLHYLLQLVQAVKFEPYHDSALSRFLLKRALQSKRIGHFLFWFLRSEIAQSMHYQQR 731

Human   713 FAVILEAYLRGCGTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNS 777
            |||||||||||||.|||.|||:||||.|:|.|||::|||:|||||||:||||:||:||||.||||
 Frog   732 FAVILEAYLRGCGKAMLDDFTRQVQVTEILHKVTMEIKSVSAEKYDVTSQVITQLRQKLEKLQNS 796

Human   778 ----QLPESFRVPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDL 838
                :||:||||||||||:||:|.:|||||||||||||||||||:|.||||||||||||||||||
 Frog   797 KLPDKLPDSFRVPYDPGLRAGSLVVEKCKVMASKKKPLWLEFKCSDTTALSNETIGIIFKHGDDL 861

Human   839 RQDMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFK 903
            |||||||||||||.||||.||||||||||||||||:|||||||||||||||:|||||||||||||
 Frog   862 RQDMLILQILRIMGSIWEAESLDLCLLPYGCISTGNKIGMIEIVKDATTIAQIQQSTVGNTGAFK 926

Human   904 DEVLNHWLKEKSPTEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHI 968
            ||||:.|||||.|.||||.|||||||||||||||||||||||||||||||:||:|||||||||||
 Frog   927 DEVLSQWLKEKCPIEEKFSAAVERFVYSCAGYCVATFVLGIGDRHNDNIMVTESGNLFHIDFGHI 991

Human   969 LGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSM 1033
            ||||||||||||||||||||||||:||||||||||.:|.||||:||||||||||||||:||||||
 Frog   992 LGNYKSFLGINKERVPFVLTPDFLYVMGTSGKKTSQYFNKFQDVCVKAYLALRHHTNLMIILFSM 1056

Human  1034 MLMTGMPQLTSKEDIEYIRDALTVGKNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQG- 1097
            ||||||||||||||||||||:||||||||.|||:||||||||||||||||||||||||||||||
 Frog  1057 MLMTGMPQLTSKEDIEYIRDSLTVGKNEESAKKHFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGV 1121

Human  1098 EKHSA 1102
            |||||
 Frog  1122 EKHSA 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CG	NP_002640.2	PIK3CG_ABD	1..192	CDD:466155	121/190 (64%)
		PI3K_rbd	203..312	CDD:197540	72/108 (67%)
		C2_PI3K_class_I_gamma	350..527	CDD:176044	144/179 (80%)
		PI3Ka_I	549..725	CDD:238444	152/175 (87%)
		PI3Kc_IB_gamma	729..1095	CDD:270627	325/369 (88%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	803..809		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	943..951		7/7 (100%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	962..988		25/25 (100%)
pik3cg	XP_012814080.1	PIK3CG_ABD	15..208	CDD:466155	121/190 (64%)
		PI3K_rbd	221..328	CDD:413336	71/106 (67%)
		C2_PI3K_class_I_gamma	366..546	CDD:176044	144/179 (80%)
		PI3Ka_I	568..744	CDD:238444	152/175 (87%)
		PI3Kc_IB_gamma	748..1118	CDD:270627	325/369 (88%)