Protein Alignment PIK3CD and VPS34

DIOPT Version :10

• Sequence 1: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_013341.1
• Gene: VPS34 / 850941
• SGDID: S000004230
• Length: 875
• Species: Saccharomyces cerevisiae
• Alignment Length: 946
• Identity: 240/946 - (25%)
• Similarity: 404/946 - (42%)
• Gaps: 222/946 - (23%)

Human   233 VEQPEDYTLQVNGRHEYLYGSYPLCQ-FQYICSCLHSGLTPHLTMVHSSSI--------LAMRDE 288
            |.|..|..|:|  :.:.|.|..||.: .|.|       |.|.|.::.|:..        |.:.|:
Yeast    10 VSQDLDVPLKV--KIKSLEGHKPLLKPSQKI-------LNPELMLIGSNVFPSSDLIVSLQVFDK 65

Human   289 QSNPAPQVQKPRAKP---PPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHG 350
            :.|      :....|   |.||.:...:...| |..|.||:     ::.....:::::..  ::|
Yeast    66 ERN------RNLTLPIYTPYIPFRNSRTWDYW-LTLPIRIK-----QLTFSSHLRIILWE--YNG 116

Human   351 NEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKAD 415
            ::.:  ...:.|.|:           |::..|.|.|........|.||:..:.....|.:.
Yeast   117 SKQI--PFFNLETSI-----------FNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQE---- 164

Human   416 CPIAWANLMLF--------DYKDQLKTG----ERCLYMWPS---------------VPDEKGELL 453
                  ||..:        .:.|::...    :|....||.               |...:.|::
Yeast   165 ------NLNKYFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVFIEREIM 223

Human   454 NP---TGTVRSNP--NTD------SAAALLICL------------PEVAPHPVYYPALEKILELG 495
            |.   ..|:::||  :||      :...:.|.|            |:   .|...|..||...|.
Yeast   224 NTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPD---QPNNDPIEEKYRRLE 285

Human   496 RHSECVHVTEE------EQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTK 554
            |.|:..::.::      ::..|.:|:......:|..|||..:||.|:.:..: .:||.:||..|.
Yeast   286 RASKNANLDKQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMNN-KKALTKLLQSTN 349

Human   555 WNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVL 619
            ..:..:..::|.|:.||.|:.:..|||||..:|.:..|.|:|:..|:|.:|.||..||||||:.:
Yeast   350 LREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVEAV 414

Human   620 KYE---------------------------------SYLDCELTK-------------------- 631
            .:|                                 |:.:.:|.|
Yeast   415 CFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVISP 479

Human   632 ---FLLDRALANRKIGHFLFWHLRSEM----HVPSVALRFGLILEAYCRGSTHHMKVLMKQGEAL 689
               ||:.|||.|.::|.|.:|:|:||.    ::..:...|...|:...|      .:|..|...:
Yeast   480 LAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSR------NILNDQVRLI 538

Human   690 SKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDS 754
            :.|:...:.:|.....|.| :.:.|:||...:...|..:..:..||||..|:.:||.|......|
Yeast   539 NVLRECCETIKRLKDTTAK-KMELLVHLLETKVRPLVKVRPIALPLDPDVLICDVCPETSKVFKS 602

Human   755 KMKPLWIMYS---NEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCL 816
            .:.||.|.:.   |:      ...::||.|||||||.|.:|:|.||:.|.|.|.:||::|||..|
Yeast   603 SLSPLKITFKTTLNQ------PYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKIL 661

Human   817 PTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAI-----EEFT 876
            .||.:.|.||.: .:||:|:| |:|.:          .:|.:||...|.|.....:     :.|.
Yeast   662 ATGPQEGAIEFI-PNDTLASI-LSKYH----------GILGYLKLHYPDENATLGVQGWVLDNFV 714

Human   877 LSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHV 941
            .|||||||.||:||:||||.||:::...|..||.|||:.||.....|....:..|        .:
Yeast   715 KSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPP--------QI 771

Human   942 IQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKD--IQYLKDSLAL 1004
            |:......|..:::||.||..||:||||:..|.|:||.||:.:.:|::....:  |..:::...|
Yeast   772 IEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERFNL 836

Human  1005 GKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1040
            ..:||:|..||:...|:::.......::.| ||:::
Yeast   837 NMSEEDATVHFQNLINDSVNALLPIVIDHL-HNLAQ 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483
		PI3K_rbd	175..281	CDD:395642	15/48 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312		6/27 (22%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	33/216 (15%)
		PI3Ka	503..684	CDD:214537	59/246 (24%)
		PI3Kc_IA_delta	676..1042	CDD:270718	120/375 (32%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		1/5 (20%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		8/25 (32%)
VPS34	NP_013341.1	TEL1	<1..872	CDD:227365	240/946 (25%)
		PI3Kc_III	528..871	CDD:270628	121/376 (32%)