Protein Alignment PIK3CD and pik3cb

DIOPT Version :10

• Sequence 1: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_001072928.1
• Gene: pik3cb / 780390
• XenbaseID: XB-GENE-482674
• Length: 1065
• Species: Xenopus tropicalis
• Alignment Length: 1069
• Identity: 582/1069 - (54%)
• Similarity: 770/1069 - (72%)
• Gaps: 35/1069 - (3%)

Human     1 MPPGVDCPMEFWTKEE--NQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLS 63
            |||.:| .|:.||.:.  ...:.||.|||||:|:...|.|:|::|.||||||..||..||||:|.
 Frog     1 MPPIMD-HMDIWTADTPLPPDICVDVLLPTGIYVQMDVPRDASISHIKQLLWKHAQSYPLFHLLL 64

Human    64 GPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEF 128
            ..::|:|.|:|..|..:|||||.:|||||:||||||:||:|..:..:|| :|:|.:||||||.||
 Frog    65 EIDSYMFQCVNHNAVHEELEDETQRLCDVRPFLPVLKLVSRSCNPAEKL-DSKIGVLIGKGLQEF 128

Human   129 DSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVN 193
            |:|.|.||.:||:||....|........|.|..||:.:||.:||||.|....|.|...|  ::|.
 Frog   129 DALKDNEVMEFRSKMRSISEAKIQSLLGLTWVEWLKRTFPPELEPSIQDNIQGKLYGGN--IVVA 191

Human   194 VKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVE-QPEDYTLQVNGRHEYLYGSYPLC 257
            :.||..::.|:||||...||:.:...|:||:.|:..:...| .|||:.||||||.|:::|.:||.
 Frog   192 IHFENCQDVFSFQVSPNMVPVKVNELAIRKRLTIHGREAEEVDPEDFVLQVNGRLEFVFGDHPLI 256

Human   258 QFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR-----AKPPPIPAKKPSSVS-- 315
            |||||.:|:.:...||||:|...:|..:.|::.:......:.:     |.|.|:|.||..:..
 Frog   257 QFQYIRNCVMNKALPHLTLVECCNIKKLFDQEMSEIEHAVRRKSSMHPALPMPLPPKKRGASMKT 321

Human   316 ------LWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQR 374
                  :|::.||::|.|.:||::|.::  .::|:||||||.|:|||...:.||...::.||.:.
 Frog   322 LNMRDIVWNIVQPYKIILSKGSRLNTED--SVLVRAGLFHGTELLCKPTMTPEVQGKNDHVWNET 384

Human   375 LEFDINICDLPRMARLCFALYAVIEKAKKARSTK----KKSKKADCPIAWANLMLFDYKDQLKTG 435
            |||:||:||||||||||||:|||::|.:....||    |||.|...|:||.|.|:||||.||::|
 Frog   385 LEFEINVCDLPRMARLCFAIYAVLDKPRNKNKTKYQTIKKSGKMHFPVAWVNTMVFDYKGQLRSG 449

Human   436 ERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKIL----ELGR 496
            :..|:.|.|.|||..|:|||.||||:||.|::...|.|...:.:..|:.||..:|||    |:.|
 Frog   450 DHVLHCWSSFPDELEEMLNPMGTVRTNPYTENTTTLHIKFHDYSKEPISYPPFDKILEKAAEIAR 514

Human   497 HSECVHVT----EEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNK 557
            :|:.:..:    ::..::|:||:||....:|.|:||||:|.||::.:|:||.:|.:|||..||||
 Frog   515 NSDSLSTSGRGGKKLNIELKEIMERDPLCQLSENEKDLIWTLRYDCRENFPGSLPKLLLSVKWNK 579

Human   558 HEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYE 622
            .|||||:..||..|.:||...|||||||::||.:|..:|:..|:.::|:||.|||||||||||||
 Frog   580 LEDVAQLQALLQIWSKLPPRDALELLDFNYPDQYVREYAVNCLKPMSDEELSQYLLQLVQVLKYE 644

Human   623 SYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGE 687
            .:|||.|::|||.|||.||:||.|||||||||:|.|:|:::|||:||||||||..|||||.:|.|
 Frog   645 PFLDCALSRFLLQRALDNRRIGQFLFWHLRSEVHNPAVSVQFGLLLEAYCRGSVAHMKVLSRQVE 709

Human   688 ALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFM 752
            ||:||:.||..:||::.|..|.:.|:.||.|:|:.||.|||.|:||||:||..|:|:.||:|.:|
 Frog   710 ALNKLRTLNGLIKLNAVKLSKVKNKDNMHTCLRENAYKEALMHIQSPLNPSITLSELVVEKCKYM 774

Human   753 DSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLP 817
            |||||||||:|:|...|| .|:|||||||||||||||.||:::|||:|||:.|||||:.|||||.
 Frog   775 DSKMKPLWIVYNNRGFGS-DSLGIIFKNGDDLRQDMLALQLLRLMDMLWKEAGLDLRIVPYGCLA 838

Human   818 TGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGY 882
            ||||.|.||||..::|||:|||:.||:||.|||||||||||:|..:.|:.|:|||||||||||||
 Frog   839 TGDRCGFIEVVSAAETIADIQLDSSNLAAAAAFNKDALLNWIKECHSGDDLERAIEEFTLSCAGY 903

Human   883 CVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKT 947
            |||||||||||||:||||:|::||||||||||.|||||:||.|.|||.||||||||:|||||||.
 Frog   904 CVATYVLGIGDRHNDNIMVRKTGQLFHIDFGHILGNFKSKFKIKRERGPFILTYDFIHVIQQGKP 968

Human   948 NNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEAL 1012
            .|:|||.|||..||.||.||||:|.|.:.|||||..|||||||..|||||:||||||||.||:||
 Frog   969 GNTEKFGRFRQCCEDAYLILRRNGNLIITLFALMLTAGLPELSSVKDIQYVKDSLALGKKEEDAL 1033

Human  1013 KHFRVKFNEALRESWKTKVNWLAHNVSKD 1041
            |.||.||:|||:|||.|||||:||.:.||
 Frog  1034 KQFRQKFDEALKESWTTKVNWMAHTMRKD 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483	41/72 (57%)
		PI3K_rbd	175..281	CDD:395642	43/106 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312		7/29 (24%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	81/178 (46%)
		PI3Ka	503..684	CDD:214537	105/184 (57%)
		PI3Kc_IA_delta	676..1042	CDD:270718	253/366 (69%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		4/5 (80%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		6/7 (86%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		20/25 (80%)
pik3cb	NP_001072928.1	PI3K_p85B	35..108	CDD:460483	41/72 (57%)
		PI3K_rbd	172..279	CDD:197540	46/108 (43%)
		C2_PI3K_class_I_beta_delta	328..495	CDD:176075	81/168 (48%)
		PI3Ka_I	533..697	CDD:238444	98/163 (60%)
		PI3Kc_IA_beta	701..1062	CDD:270717	250/361 (69%)