Protein Alignment PIK3CD and Tor

DIOPT Version :9

• Sequence 1: XP_016856965.1
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1103
• Species: Homo sapiens
• Sequence 2: NP_001260427.1
• Gene: Tor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Alignment Length: 1052
• Identity: 203/1052 - (19%)
• Similarity: 340/1052 - (32%)
• Gaps: 371/1052 - (35%)

Human   100 RLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQ 164
            ||:    |..:.|::::::.:.|:...             ||.....|.:..|..:::     :|
  Fly  1530 RLI----DETRDLLDTELTSMAGESYE-------------RAYGAMVCVQMLAELEEV-----IQ 1572

Human   165 YS-FPLQLEPSAQTWGPGTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVF 228
            |. .|.:.||....|..   ||.....||      .:.....||.:
  Fly  1573 YKLIPERREPLKTMWWK---RLQGGQRLV------EDWRRIIQVHS------------------- 1609

Human   229 RQPLVEQP-EDYTLQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAM-RDEQSN 291
               ||.:| ||.       |.:|         :|...|..|| :.||:  |.:.::.: .|.:.|
  Fly  1610 ---LVVKPHEDI-------HTWL---------KYASLCRKSG-SLHLS--HKTLVMLLGTDPKLN 1652

Human   292 PAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCK 356
            |          ..|:|..:|            ::.......:.|:.:::        ...|.|..
  Fly  1653 P----------NQPLPCNQP------------QVTYAYTKYMAANNQLQ--------EAYEQLTH 1687

Human   357 TVS--SSEVSVCSEP-------------------VWKQRLEFDINICDLPRMARLCFALYAVIEK 400
            .||  |.|:| |..|                   .|:.:|:..|. .|..:.|..||      ||
  Fly  1688 FVSTYSQELS-CLPPEALKQQDQRLMARCYLRMATWQNKLQDSIR-PDAIQGALECF------EK 1744

Human   401 A-------------------KKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVP 446
            |                   |..::.|....|...|.|...:.:....|    .:..:....:||
  Fly  1745 ATSYDPNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLD----SDLMIIQRYAVP 1805

Human   447 DEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKLPGGMLLASREWR---PELLW 508
            ..:| .......::.|...|:...|.:.. :...|...|.||  |.|..|:....|.   |:|:
  Fly  1806 AVQG-FFRSISLIKGNSLQDTLRLLTLWF-DYGNHAEVYEAL--LSGMKLIEINTWLQVIPQLI- 1865

Human   509 MRLHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLLQILELGRHSECVHVTEEEQLQLREI 573
                |......:::|..:..|                    ::::|::.....|...........
  Fly  1866 ----ARIDTHRQLVGQLIHQL--------------------LMDIGKNHPQALVYPLTVASKSAS 1906

Human   574 LERRGSGELYEHEKDLVWKLRHEVQEHFP----------EALARLLLV--TKWNKHEDVAQMLYL 626
            |.||.:          .:|:...:::|.|          |.|.|:.::  .:|::..:.|..||
  Fly  1907 LARRNA----------AFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLY- 1960

Human   627 LCSWPELPVLSALELLDFSFPDCHV-GSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDC---E 687
                               |.|.:| |.|.|.       :.|...|.:..|.||..|:...   |
  Fly  1961 -------------------FGDRNVKGMFEIL-------EPLHAMLERGPQTLKETSFSQAYGRE 1999

Human   688 LTKFL--------------LDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHM 738
            ||:..              ||||           |.:                          :.
  Fly  2000 LTEAYEWSQRYKTSAVVMDLDRA-----------WDI--------------------------YY 2027

Human   739 KVLMKQGEALSKLKALN-DFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAE 802
            .|..|....|.:|.:|. .:|      :||..|.:.:.|.            :....:|...|..
  Fly  2028 HVFQKISRQLPQLTSLELPYV------SPKLMTCKDLELA------------VPGSYNPGQELIR 2074

Human   803 VCVEQCTF--MDSKMKP--LWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQE 863
            :.:.:...  :.||.:|  |.|..||     |.....:.|..:|||||...:|:..|::.|...:
  Fly  2075 ISIIKTNLQVITSKQRPRKLCIRGSN-----GKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDD 2134

Human   864 ----GLDLRMTPYGCLPTGDRTGLIEVVLRSDTI----------ANIQLNKSN------------ 902
                ..:|.:..|..:|....:|||..|...||:          ..:.||:.:
  Fly  2135 PDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDH 2199

Human   903 ---MAATAAFNKD---------ALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHS 955
               |.....|...         |.|.||||.:.....:|. ..:|.|.|...:..|:||:||||.
  Fly  2200 LTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERR-NNYTRSLAVMSMVGYILGLGDRHP 2263

Human   956 DNIMI-RESGQLFHIDFGHF--LGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRG 1017
            .|:|: |.||::.|||||..  :...:.||   .|::||.||...:..::......:     :|.
  Fly  2264 SNLMLDRMSGKILHIDFGDCFEVAMTREKF---PEKIPFRLTRMLIKAMEVTGIEGT-----YRR 2320

Human  1018 YCERAYTILRRH 1029
            .||....:|||:
  Fly  2321 TCESVMLVLRRN 2332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	XP_016856965.1	PI3K_p85B	32..107	CDD:308030	2/6 (33%)
		PI3K_rbd	175..281	CDD:307097	21/106 (20%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	32/206 (16%)
		PI3Ka	562..743	CDD:214537	35/210 (17%)
		PI3Kc_IA_delta	735..1101	CDD:270718	82/341 (24%)
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	203/1052 (19%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	28/160 (18%)
		PIKKc_TOR	2075..2353	CDD:270713	70/272 (26%)
		FATC	2440..2471	CDD:280430

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900