Protein Alignment PIK3CD and fwd

DIOPT Version :9

• Sequence 1: XP_016856965.1
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1103
• Species: Homo sapiens
• Sequence 2: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Alignment Length: 671
• Identity: 148/671 - (22%)
• Similarity: 249/671 - (37%)
• Gaps: 189/671 - (28%)

Human   439 LYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKLPGGMLLASREWR 503
            |..|||..::...|......:    |.:..|.:.:.|....||.|.....||.   .:|.|::..
  Fly  1155 LTSWPSKAEKTSALRMSLNLI----NKNLPARVWLPLYSDIPHHVVRITEEKT---AVLNSKDKT 1212

Human   504 PELLWMR-LHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLLQILELGRHSECVHVTEEEQ 567
            |.::::. :...|...|.:|...||.|.....  :...|..|....|.|...|.|.|....:...
  Fly  1213 PYIIYVEVVEIPDIYTSPLIPKMMPSLRHTKS--EEHLDGSCLNSHQHLSCSRTSSCSSSQQGTS 1275

Human   568 LQLREILE-RRGSGELYEH--------------EKDLVWKLRHEVQEHFPEALARLLLVTKWNKH 617
            .:.::..: ..|.|:...|              ::|.||....:      |..|:.|.:.|.::.
  Fly  1276 CRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEED------EITAQYLNMRKVSER 1334

Human   618 EDVAQMLYLLCSWPEL--PVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKY 680
            :.::|:....|...:.  ||:                 |.|..:|                 |::
  Fly  1335 DTISQISLDSCDSRDQGPPVV-----------------FNIGDVR-----------------LRH 1365

Human   681 ESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQG 745
            .|.|.||.||                  ...::...||.|    .:.|.:      |.|
  Fly  1366 CSNLSCENTK------------------SFSNDPEDPSAA----ALKEPW------HEK------ 1396

Human   746 EALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTF 810
                        .||..:.:|                    ..||.:
  Fly  1397 ------------EKLIRESSP--------------------YGHLSN------------------ 1411

Human   811 MDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCL 875
                    |.:.|           .|.|.||||||:::..|::|:..::|::|.:||.:.||..:
  Fly  1412 --------WRLLS-----------AIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIV 1457

Human   876 PTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAG 940
            ...:.:||||.:|.:.::..|:.| ||.:.     |:..::...|.: ||:..||.:.|..|||.
  Fly  1458 CLSNDSGLIEPILNTVSLHQIKKN-SNKSL-----KEYFIDEYGSPS-GESFRRAQKNFVQSCAA 1515

Human   941 YCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGK 1005
            ||:.:|:|.:.|||:.||:....|.:.|||||..|.......|.  |:.||.||.:||.|:  |.
  Fly  1516 YCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVM--GG 1576

Human  1006 TNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRA-AGLP--ELSCSKDIQYLKDSLALGKTE 1067
            | :||.:..|...........|:|....::...:||: |.||  :..||..:|.|:....:..||
  Fly  1577 T-SSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTE 1640

Human  1068 EEALKHFRVKFNEALRESWKT 1088
            :|..:    |..:.:::|.|:
  Fly  1641 QEMER----KVEQLVQDSLKS 1657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	XP_016856965.1	PI3K_p85B	32..107	CDD:308030
		PI3K_rbd	175..281	CDD:307097
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	8/41 (20%)
		PI3Ka	562..743	CDD:214537	30/197 (15%)
		PI3Kc_IA_delta	735..1101	CDD:270718	91/357 (25%)
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	94/374 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810