DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIK3CD and Pi3K92E

DIOPT Version :9

Sequence 1:	XP_016856965.1	Gene:	PIK3CD / 5293	HGNCID:	8977	Length:	1103	Species:	Homo sapiens
Sequence 2:	NP_001262770.1	Gene:	Pi3K92E / 42446	FlyBaseID:	FBgn0015279	Length:	1088	Species:	Drosophila melanogaster

Alignment Length:	1140	Identity:	430/1140 - (37%)
Similarity:	625/1140 - (54%)	Gaps:	116/1140 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     2 PPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPE 66
            ||.:...:..|..|....|.:..|||.|..|...|:....:..||..:.::|:..||.:::....
  Fly    27 PPCMRFSVNLWKNEMLNWVDLICLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLGYVIKEAC 91

Human    67 AYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDR-----------VKKLINSQISLL 120
            .|....|: |...:...||.:||.:|||:..:|.|    |:|           :.|::|.    :
  Fly    92 EYQVYGIS-TFNIEPYTDETKRLSEVQPYFGILSL----GERTDTTSFSSDYELTKMVNG----M 147

Human   121 IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTL-- 183
            ||.......:...||::|||..|.|.|:.....|....|:..|.|..||:|..|.:.  |..:
  Fly   148 IGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANSTKM--PELIRE 210

Human   184 RLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHE 248
            |.|.|..|:.||.|..:.:||..|:.:|.|.:|....| :|....:..:.::..||.|:|:||.|
  Fly   211 RHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTL-QKMNRSQMKMNDRTSDYILKVSGRDE 274

Human   249 YLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSS 313
            ||.|.|||.||.||...|.....|::.:.....:.:..:..:..|...::|..|...:...|..|
  Fly   275 YLLGDYPLIQFLYIQEMLSDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLPKKRTVHLHKSIS 339

Human   314 VSLWSLEQPFRIELIQGSKVNADE--RMKLVVQAGLFHGNEMLCKTVSSS------EVSVCSEPV 370
             |||.:...|::.|...|.||.|:  .:|:.|...|:||::.||...|:.      :..:.::.|
  Fly   340 -SLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDKKLCAQRSTDSPNGNFDTFLFNDLV 403

Human   371 WKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADC----------PIAWANLML 425
                ::|||.:.:||||.|||..::   |..|.:|| ||.|...|.          |:||.|..:
  Fly   404 ----MDFDIQMRNLPRMTRLCIVIF---EVTKMSRS-KKSSNNKDIALKDVPYNKNPLAWVNTTI 460

Human   426 FDYKDQLKTGERCLYMWPSVPD-EKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALE 489
            ||:||.|:||...||.|....| :..|:.:|.||:..||..:..|.:.:.........|.||:.|
  Fly   461 FDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEE 525

Human   490 KLPGGMLLASREWRPELLWMRLHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLLQILELG 554
            .                                            ::|...|.|....||....|
  Fly   526 V--------------------------------------------VLQYAADREQVNRLQRQLAG 546

Human   555 RHSECVHVTEEEQLQLREILER-RGSGELYE---HEKDLVWKLRHEVQEHFPEALARLLLVTKWN 615
                    .|:...:|:|::.. .|..::||   .:::.:|:.|:::....||.|:.||....|.
  Fly   547 --------PEKPIKELKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWK 603

Human   616 KHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKY 680
            :.:|||.|.|||..||.:.:..:|||||:::||..|..|||:.|..|.|::|..|||||||.:|:
  Fly   604 ERDDVADMWYLLKQWPLISIERSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKH 668

Human   681 ESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQG 745
            ||||:.:|..|||:|||.|::|||:.||||||||..||:..||||:||.|.:|..||:..|.||.
  Fly   669 ESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQL 733

Human   746 EALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTF 810
            ..|.|||.    ..|.::|..|.:.|.::...:|.:.......::|:||:||...:.|..::|..
  Fly   734 HVLEKLKQ----GSLIAKKGSKEKVKTMLQDFLRDQRNSAVFQNIQNPLNPSFRCSGVTPDRCKV 794

Human   811 MDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCL 875
            |||||:|||:::.|.:. :...|.||||||||||||||||||:::||.|||::|:|.||..|.|:
  Fly   795 MDSKMRPLWVVFENADV-NASDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCI 858

Human   876 PTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKN-PGEALDRAIEEFTLSCA 939
            ......|:||||..::||||||..|...:||:.|.|.:||:|||..| |.:.|::||.|||||||
  Fly   859 SMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCA 923

Human   940 GYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQG 1004
            ||||||||||:.||||||||::.:||||||||||.||:||.|.|:.||||||:||:|||:||.:|
  Fly   924 GYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKG 988

Human  1005 -KTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEE 1068
             ....|::|..|:..||||:.:||:||.|.|.||::|.:.||||||..||:.||:::|.|..|||
  Fly   989 FNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEE 1053

Human  1069 EALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ 1103
            :|.:|||.||:|||..||||.:||.:||.||:|:|
  Fly  1054 KAREHFRAKFSEALANSWKTSLNWASHNFSKNNKQ 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	XP_016856965.1	PI3K_p85B	32..107	CDD:308030	19/74 (26%)
		PI3K_rbd	175..281	CDD:307097	35/107 (33%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	58/185 (31%)
		PI3Ka	562..743	CDD:214537	82/184 (45%)
		PI3Kc_IA_delta	735..1101	CDD:270718	191/367 (52%)
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	21/80 (26%)
		PI3K_rbd	200..307	CDD:197540	36/109 (33%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	59/186 (32%)
		PI3Ka_I	552..723	CDD:238444	78/170 (46%)
		PI3Kc_I	727..1084	CDD:270709	187/361 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146185
Domainoid	1	1.000	276	1.000	Domainoid score	I1749
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3686
Inparanoid	1	1.050	734	1.000	Inparanoid score	I605
Isobase	1	0.950	-	0	Normalized mean entropy	S3198
OMA	1	1.010	-	-		QHG57536
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001201
OrthoInspector	1	1.000	-	-		otm42149
orthoMCL	1	0.900	-	-		OOG6_100986
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5021
SonicParanoid	1	1.000	-	-		X531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750