Protein Alignment PIK3CD and pik3cd

DIOPT Version :10

• Sequence 1: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_957493.1
• Gene: pik3cd / 394174
• ZFINID: ZDB-GENE-040426-1128
• Length: 1039
• Species: Danio rerio
• Alignment Length: 1045
• Identity: 728/1045 - (69%)
• Similarity: 859/1045 - (82%)
• Gaps: 8/1045 - (0%)

Human     1 MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGP 65
            |||||....|.|..|..|.|.::||||||:||||.|:.:..:||||::||..|:.||||..||.|
Zfish     1 MPPGVYGMQEVWEMEGRQHVNIEFLLPTGIYLNFTVACSDTISTIKKMLWKNAKNEPLFSALSDP 65

Human    66 EAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDS 130
            :||||||||.|||::||||||||||||:||||:|||||||||||:|||.:||:.|||||.|||||
Zfish    66 DAYVFTCINMTAEREELEDEQRRLCDVRPFLPILRLVAREGDRVEKLITTQINQLIGKGHHEFDS 130

Human   131 LCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVK 195
            ..:.|:|:||.||..||||.|..||.|.|:.|::|:||..|||.:.....|..| ..:.:.||||
Zfish   131 QKNHELNEFRTKMRAFCEEHAYLRQTLPWDKWMEYNFPCDLEPCSSVTQSGKSR-SIKKIFVNVK 194

Human   196 FEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQ 260
            ||||||:|..|...:|:|:.|...|||||:||||....|:||||:||||.|.|::||.||||||:
Zfish   195 FEGSEETFVLQQDPQDLPVVLKRNALRKKSTVFRSVKQEKPEDYSLQVNERWEFIYGKYPLCQFK 259

Human   261 YICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRA--KPPPIPAKKPSSVSLWSLEQPF 323
            ||.:|||.||||||||||.|||:..::|||..:.||.:.||  ||||:|.|:.::.||||:::||
Zfish   260 YIFTCLHGGLTPHLTMVHYSSIVKYQEEQSGLSNQVSRSRAQSKPPPLPLKRQNTCSLWSIQEPF 324

Human   324 RIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMA 388
            .|.|:|||:|||||.||||||||||||:|:|||.|:|:|||||.:|||.|:|.||||:.|||||:
Zfish   325 YIYLLQGSRVNADEGMKLVVQAGLFHGSELLCKVVTSNEVSVCFDPVWDQKLVFDINVSDLPRMS 389

Human   389 RLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELL 453
            |||||||.||||.|| |.||||:|:||||:||.|.|:|||||||||||..|..||||||:||:||
Zfish   390 RLCFALYGVIEKTKK-RPTKKKNKRADCPLAWVNTMVFDYKDQLKTGEFSLSTWPSVPDDKGDLL 453

Human   454 NPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERR 518
            ||.|||..|||.||.|.|||..|.:.|||:|||.:||:.|||.:.|.|..|:||..:|:||::.:
Zfish   454 NPMGTVEKNPNIDSTAGLLIRFPNIRPHPLYYPPIEKLNELGPNGEKVIATKEEHQKLKEIVDNK 518

Human   519 GSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELL 583
            .|.|.:|.||:.:||||.|::..:||:|.:|||:||||||||||||:.||..|||||.|.|||||
Zfish   519 NSTEFFEDEKEPLWKLREELRLKYPESLPKLLLITKWNKHEDVAQMVGLLQKWPELPALHALELL 583

Human   584 DFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLF 648
            |:||||.||..|.|:.||||.||:||||||||||||||||||||:||.|||:|||||:|||||||
Zfish   584 DYSFPDPHVRFFTIRCLRKLPDDKLFQYLLQLVQVLKYESYLDCDLTSFLLERALANKKIGHFLF 648

Human   649 WHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKE 713
            ||||||||||||:||||||||||||||..|:|.||||.|||:|:||||||||.:|||..:.||.|
Zfish   649 WHLRSEMHVPSVSLRFGLILEAYCRGSIFHIKSLMKQNEALNKMKALNDFVKSASQKATRIQTTE 713

Human   714 LMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIF 778
            .|.:|::||.|:||||.:.|||.||.:|.|:|.::|.||||||||||:||.::.    .||||||
Zfish   714 DMKVCIKQETYMEALSDVVSPLSPSIILCELCADKCKFMDSKMKPLWLMYKSKY----DSVGIIF 774

Human   779 KNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSN 843
            |||||||||||||||||:||:|||.|||||||.|||||.||::|||||||..||||||||.|.||
Zfish   775 KNGDDLRQDMLTLQMIQIMDILWKTEGLDLRMQPYGCLSTGNKTGLIEVVKNSDTIANIQRNNSN 839

Human   844 MAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLF 908
            .|||||||||||||||||||||:.||:||||||||||||||||||||||||||||||||||||||
Zfish   840 SAATAAFNKDALLNWLKSKNPGDKLDQAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLF 904

Human   909 HIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLL 973
            ||||||||||||:||||||||||||||||||||||:|:|||||||||||..||:||.||.|:|.|
Zfish   905 HIDFGHFLGNFKSKFGINRERVPFILTYDFVHVIQEGRTNNSEKFERFRVCCEQAYKILCRNGTL 969

Human   974 FLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNV 1038
            |::|||||:|||||||:.|||||||||||||||:||||||:|:|||||||||||||||||:.|..
Zfish   970 FVNLFALMKAAGLPELNSSKDIQYLKDSLALGKSEEEALKNFKVKFNEALRESWKTKVNWMMHTF 1034

Human  1039 SKDNR 1043
            :||||
Zfish  1035 AKDNR 1039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483	50/72 (69%)
		PI3K_rbd	175..281	CDD:395642	60/105 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312		13/26 (50%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	117/166 (70%)
		PI3Ka	503..684	CDD:214537	128/180 (71%)
		PI3Kc_IA_delta	676..1042	CDD:270718	284/365 (78%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		7/7 (100%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		24/25 (96%)
pik3cd	NP_957493.1	PI3K_p85B	34..107	CDD:460483	50/72 (69%)
		PI3K_rbd	188..280	CDD:413336	58/91 (64%)
		C2_PI3K_class_I_beta_delta	315..481	CDD:176075	117/166 (70%)
		PI3Ka_I	505..676	CDD:238444	123/170 (72%)
		PI3Kc_IA_delta	676..1038	CDD:270718	284/365 (78%)