Protein Alignment PIK3CD and Pik3cd

DIOPT Version :10

• Sequence 1: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Sequence 2: XP_038966422.1
• Gene: Pik3cd / 366508
• RGDID: 1310990
• Length: 1048
• Species: Rattus norvegicus
• Alignment Length: 1048
• Identity: 981/1048 - (93%)
• Similarity: 1007/1048 - (96%)
• Gaps: 4/1048 - (0%)

Human     1 MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGP 65
            ||||||||||||||||:|||.||||||||||||||||||||||||||:|||||||||.|||||.|
  Rat     1 MPPGVDCPMEFWTKEESQSVAVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPFFHMLSDP 65

Human    66 EAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDS 130
            |||||||:||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
  Rat    66 EAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDS 130

Human   131 LCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVK 195
            |.||||||||.||.||||||||.||||||..||||||||||||||:.|..|.|.:.||.||||||
  Rat   131 LRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRAGLLHVSNRPLLVNVK 195

Human   196 FEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQ 260
            ||||||||||||||||:||||||||||||||||||||||:||:|.|||||||||||||||||.||
  Rat   196 FEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVERPEEYALQVNGRHEYLYGSYPLCHFQ 260

Human   261 YICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRI 325
            ||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||.|
  Rat   261 YICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRVKPPPIPAKKPSSVSLWSLEQPFCI 325

Human   326 ELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARL 390
            |||:|.||||||||||||||||||||||||||||||||:|||||||||||||||:||||||||||
  Rat   326 ELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISICDLPRMARL 390

Human   391 CFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNP 455
            |||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
  Rat   391 CFALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELMNP 455

Human   456 TGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGS 520
            .||||.||||:|||||:|.||||||||||:||||||||||||.|...:|||||||||||||||||
  Rat   456 AGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEQLQLREILERRGS 520

Human   521 GELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVA---QMLYLLCSWPELPVLSALEL 582
            |||||||||||||:||||||||||||||||||||||||||||   ||||||||||||||||||||
  Rat   521 GELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQLSQMLYLLCSWPELPVLSALEL 585

Human   583 LDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFL 647
            ||||||||:|||||||||||||||||||||||||||||||||||||||||||.||||||||||||
  Rat   586 LDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLGRALANRKIGHFL 650

Human   648 FWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTK 712
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||.|||||.|||||
  Rat   651 FWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKASSQKTTKPQTK 715

Human   713 ELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVC-VEQCTFMDSKMKPLWIMYSNEEAGSGGSVGI 776
            |:||:|||||.|:||||||||||||||||.||| |||||||||||||||||||:|:||..|||||
  Rat   716 EMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCSVEQCTFMDSKMKPLWIMYSSEKAGGAGSVGI 780

Human   777 IFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNK 841
            ||||||||||||||||||||||.||||||||||||||||||||||||||||||.|||||||||||
  Rat   781 IFKNGDDLRQDMLTLQMIQLMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNK 845

Human   842 SNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQ 906
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   846 SNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQ 910

Human   907 LFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHG 971
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   911 LFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHG 975

Human   972 LLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAH 1036
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   976 LLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAH 1040

Human  1037 NVSKDNRQ 1044
            ||||||||
  Rat  1041 NVSKDNRQ 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483	67/72 (93%)
		PI3K_rbd	175..281	CDD:395642	91/105 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312		23/24 (96%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	154/166 (93%)
		PI3Ka	503..684	CDD:214537	175/183 (96%)
		PI3Kc_IA_delta	676..1042	CDD:270718	352/366 (96%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		7/7 (100%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		25/25 (100%)
Pik3cd	XP_038966422.1	PI3K_p85B	34..107	CDD:460483	67/72 (93%)
		PI3K_rbd	182..281	CDD:395642	88/98 (90%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	154/166 (93%)
		PI3Ka	504..687	CDD:214537	175/182 (96%)
		PI3Kc_IA_delta	679..1046	CDD:270718	352/366 (96%)