DRSC/TRiP Functional Genomics Resources

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Protein Alignment PIK3CD and mei-41

DIOPT Version :9

Sequence 1:XP_016856965.1 Gene:PIK3CD / 5293 HGNCID:8977 Length:1103 Species:Homo sapiens
Sequence 2:NP_523369.2 Gene:mei-41 / 32608 FlyBaseID:FBgn0004367 Length:2517 Species:Drosophila melanogaster


Alignment Length:1238 Identity:239/1238 - (19%)
Similarity:411/1238 - (33%) Gaps:399/1238 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    83 EDEQR------RLCDVQPFLPVLRLVAREGDRV---------KKLINSQISLLIGKGLHEFDSLC 132
            ||..|      :||  ...|..|:...||..|:         .:.|:|..     :.:|||.:|.
  Fly  1448 EDSSRVPRLAGKLC--AELLDFLQRWLREWQRIHGRSTGGKPPETIDSNY-----RKIHEFLNLI 1505

Human   133 DPEVNDFRAKM-C-----------QFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRL 185
             |::...||.. |           .:.||...:.|:|    ..|::|.:::.        |:||.
  Fly  1506 -PKLLVSRASYNCGEYARALSYLESYLEEGEDKSQRL----LEQFTFLVEVY--------GSLRD 1557

Human   186 PNRALLVNVKFEGSEESFTFQVS-TKDVPLALMACALRKKATVFRQPLVE----QPEDYTLQVNG 245
            |:       ..||:.:..::.:| |:|:.:..:....:...|.:.|.|..    ||:.....::.
  Fly  1558 PD-------SVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQPDHVRAMIDA 1615

Human   246 RHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILA---------------MRDEQSNPAPQ 295
               ||..:....|.      :..||...|:..:|....|               |.:.|||...|
  Fly  1616 ---YLRDTPKTAQL------IADGLWQRLSDRYSDQCFAECKSELLWRLGSYDEMEELQSNWPAQ 1671

Human   296 VQKPRAKPPPIPAKKPSSVSLWSLEQPF--RIE---LIQGSKVNADERMKLVVQAGLFHGNEMLC 355
            ..:...|                |.:|.  |||   |:.|.:.:..|.::             .|
  Fly  1672 CSQGCLK----------------LRRPLTTRIEFDSLLDGMRESVLEELR-------------SC 1707

Human   356 KTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW 420
            ..|.....:...:.|.|..|..::: |.           ..::||.::.|....:.|        
  Fly  1708 SAVQQHSYANAYDAVLKLHLVHELH-CS-----------QELVEKLEQDRDEDNQEK-------- 1752

Human   421 ANLMLFDYKD-----------QLKTGERCL------------------YMWPSVPDEKGELLNPT 456
               ::.:|.|           |::..|...                  ::.|.:..|...:...:
  Fly  1753 ---LMKNYFDDWQYRLQIVQPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNS 1814

Human   457 GTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKLPGGMLLASREWRPELLW------------- 508
            ..:..|......|.|.|           ..|.|..|.|:.:.    |.:|||             
  Fly  1815 AQINRNAGQLQRAQLYI-----------LKAAEYQPSGLFIE----RAKLLWQKGDQVMAMNYLE 1864

Human   509 -----MRLHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLL---------QILELGRHSEC 559
                 ||...:.:.  :.:......|......:||...||...|.         :.:.:.|.||.
  Fly  1865 EQLSIMRSGCQGNV--KQLAAEQRHLFFRGKYLQAVYSAESMHLCADAVLKYFQEAIAVHRQSES 1927

Human   560 VHVTEEEQLQLREILERR--GSGELYEHEKDLV--------WKLRHEVQEHFPEALARLLLVTKW 614
            .||...:.|:  :|||.|  |..|....:.|::        ..||:. .||..:::.|  |::.|
  Fly  1928 CHVQMAQFLE--KILEARQGGKSEPTGEQDDMLINVMVNYAKSLRYG-SEHVYQSMPR--LISLW 1987

Human   615 -------NKHEDVAQMLYLL---CSWPELP----------VLSALELLDFSFPDCHVGSFAIKSL 659
                   ...|.|.:|..||   |:  .||          :||.|         ||..:.....|
  Fly  1988 LDTTESSTNTEQVKKMNDLLTNCCT--ALPTAVFYTVYSQMLSRL---------CHPVNDVFTVL 2041

Human   660 R----KLTD---DELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVP 717
            |    ||.:   .:....||...:..|......|:|.  |.|..|.|.                 
  Fly  2042 RNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLV--LTDSRLQNS----------------- 2087

Human   718 SVALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEA 782
                .|..:|:.: ...|..:..|..:...|.:...|:|.....|:...:|:..:::   :..|.
  Fly  2088 ----TFQKLLQDF-NSLTERLMDLTNKEVTLDRTYKLSDLDTRLSKLCKQPEFSQIL---LPFEK 2144

Human   783 YLEAL------------SHLQSPLDPSTL----LAEVCV----EQCTFMDSKMKP--LWIMYSNE 825
            |::..            |||  |.:.||:    ..::.:    |....:.|..||  |.|..|: 
  Fly  2145 YMQPTLPLNSDSNSSEGSHL--PANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSD- 2206

Human   826 EAGSGGSVGIIFKNGDDLRQDMLTLQMIQLM------DVLWKQEGLDLRMTPYGCLPTGDRTGLI 884
                |....::.|..||||:|...::...|:      |...:|..|.:|  .|..||..:..||:
  Fly  2207 ----GKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIR--TYAVLPFNEECGLV 2265

Human   885 E--------------------VVLRSDTIAN--IQLNKSNMAATAAFNKD-------ALLNWLKS 920
            |                    :|:.:..:.:  :.|::|.......|.|.       ....||:.
  Fly  2266 EWLPNLASYRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQ 2330

Human   921 K--NPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRE-SGQLFHIDF------GHFLG 976
            :  .| .:...|...:..:.|...:..|:||:||||.:||:..| :|...|:||      |..|.
  Fly  2331 RFATP-HSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLP 2394

Human   977 NFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLL-------FL 1034
                    ..|.|||.||::.:..:.......|     ||..||....:|::....       |:
  Fly  2395 --------YPEVVPFRLTHNMIVAMGPLGVEGS-----FRKCCEITLRLLKQESKTLMSILRPFV 2446

Human  1035 HLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1099
            :........|......:||:|.:.|.|.         .|.:.:...::..|.:.:||:|.:..:|
  Fly  2447 YDVGAQTRKGAATAKITKDVQRIADRLQ---------GHVKRQQANSIPLSTEGQVNFLINEATK 2502

Human  1100 -DN 1101
             ||
  Fly  2503 VDN 2505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PIK3CDXP_016856965.1 PI3K_p85B 32..107 CDD:308030 9/29 (31%)
PI3K_rbd 175..281 CDD:307097 21/110 (19%)
C2_PI3K_class_I_beta_delta 314..481 CDD:176075 28/200 (14%)
PI3Ka 562..743 CDD:214537 46/217 (21%)
PI3Kc_IA_delta 735..1101 CDD:270718 91/439 (21%)
mei-41NP_523369.2 UME 955..1060 CDD:214825
FAT 1653..1985 CDD:280429 69/405 (17%)
PIKKc_ATR 2181..2448 CDD:270625 64/287 (22%)
FATC 2486..2517 CDD:280430 7/20 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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