Protein Alignment PIK3CD and Pi4KIIIalpha

DIOPT Version :9

• Sequence 1: XP_016856965.1
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1103
• Species: Homo sapiens
• Sequence 2: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Alignment Length: 1324
• Identity: 262/1324 - (19%)
• Similarity: 442/1324 - (33%)
• Gaps: 478/1324 - (36%)

Human    31 YLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPF 95
            ||:|.|.|      ...|||:|.               |..|:
  Fly  1023 YLSFLVDR------FPHLLWNRR---------------VLWCM---------------------- 1044

Human    96 LPVLRLVA-------REGDRVKKLINSQISLLIGKGLHEFDSLCDPE--VNDFRAKMCQ-FCEEA 150
            |.:|:|:|       .|.....:::::..:|.:      .|||...|  :.|| |..|| ...||
  Fly  1045 LDILQLLAYSLSLDPNEETPTLRVVSTPYTLQL------MDSLPARELRLKDF-ADRCQGIVNEA 1102

Human   151 ---AARRQQ--------------LGWEAWLQYSFPLQLEPSAQTWGPGTLRLPN----------R 188
               |.|..:              |...:.|..:|...:..|||..|..:.| |:          .
  Fly  1103 MKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKR-PSCVNSDTPRFVS 1166

Human   189 ALLVNVKFEGSEESFTFQVSTKD--------VPLALMACALRKKATVFRQPLVEQPEDYTLQVNG 245
            .|.:..|:.|........:|.||        |.....|||.:..|
  Fly  1167 VLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSDA-------------------- 1211

Human   246 RHEYLYGS-YPLCQFQYICS-----CLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPP 304
            ||.   |: :....:..|||     .||:..:..|.:...|::
  Fly  1212 RHR---GALWRATAYLIICSEISRKLLHAVASSQLELFTESAM---------------------- 1251

Human   305 PIPAKKPSSVSLW--------SLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEML------- 354
                  .::|..|        .||..|..|::...:...::||      |||.....:
  Fly  1252 ------ETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRM------GLFAWETEVTHPLAAY 1304

Human   355 --CKTVSSSEVSVCSEPVWKQRLEFDIN---ICDLPRMARLCFALYAVIEKAKKARSTKKKS--- 411
              ||.| |..:.:....:|.|.|...::   .|:..::...|..|:..:...|.::..::.|
  Fly  1305 EGCKLV-SKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVG 1368

Human   412 ---KKADCPIA--------------------WANLMLFDY-----------KDQLKTGERCLY-M 441
               |...|.::                    ::|.:  ||           ::||......|. .
  Fly  1369 CRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNAL--DYFCGPPTCPNQSREQLLEDIMILLKF 1431

Human   442 WPSVPDEKGELL-NPTG---------------TVRSNPNTDSAAALLICLPEVAPHPVYYPALEK 490
            |.::..||..|: :..|               .||:||.|.|.
  Fly  1432 WQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASL---------------------- 1474

Human   491 LPGGMLLASREWRPELLWMRLHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLLQILELGR 555
            :.||.|:  .::...:         ||....:|:   |:||..|     |.:.          |.
  Fly  1475 ISGGGLV--NDYTRSM---------SASGNAVGM---GMGVAGG-----GSSS----------GW 1510

Human   556 HSECVHVT--------EEEQLQL------REILERR----------------------------- 577
            ::...|.|        ..::||.      ::.:::|
  Fly  1511 YNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLPDLIVP 1575

Human   578 GSGELYEHE----KDLVWK--------------------------LRHEVQE----------HFP 602
            |..::.|..    |..||:                          :..||..          |.|
  Fly  1576 GEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIP 1640

Human   603 EALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCH--VGSFAIKSLRKLTDD 665
            ||| :.|..|| |..::...::|:| ||..:..:.||......:|. |  ...:|:|:|.....:
  Fly  1641 EAL-KYLCTTK-NLLQESPDLVYIL-SWSPVTPIQALAYFSRQYPS-HPLTAQYAVKTLSSYPAE 1701

Human   666 ELFQYLLQLVQVLKYES--YLDCELTKFLLDRALANRKIGHFLFWHLRSEMHV------------ 716
            .:..|:.||||.|::::  |    :.:|:.:.:..::.:.|.|.|::::.|::
  Fly  1702 SVLPYIPQLVQALRHDTMGY----VVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLY 1762

Human   717 -------PSVALRF-GLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKEL 773
                   .|:...| |.....|.|......|:....||..|..|.:.
  Fly  1763 EALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIE------------------ 1809

Human   774 MHLCMRQEAYLEALSHLQ------SPLDPSTLLAEVCVEQCTFMDSKMKPLWI----MY------ 822
                 |:.|.|.|||.::      .|.:|..::.::.....|.|.|..|..::    :|
  Fly  1810 -----RKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITE 1869

Human   823 -----------SNEEAGSGGSVGI------IFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMT 870
                       .|.:..:..::|:      |||.|||:|||||.||:|.:...:::|.||||.:.
  Fly  1870 LETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLF 1934

Human   871 PYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFT 935
            ||..:.|....|:||.|  .:..:..||.:...:..:.:.:...     .....:....|...|.
  Fly  1935 PYRVVATAPGCGVIECV--PNAKSRDQLGRQTDSGLSEYFQHQY-----GDESSKEFQAARANFV 1992

Human   936 LSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHV 1000
            .|.|.|.:..|:|.|.|||:.||||.:.|.:.|||||..   |::..|.|....|.:...|.:.:
  Fly  1993 KSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFM---FESSPGGNIGFEPDMKLTDEMVM 2054

Human  1001 IQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSC--SKDIQYLKDSLAL 1063
            |..||. :|..|:.|...|.:|:..:|.:....:.|.:||...|||   |  .:.|..||.....
  Fly  2055 IMGGKM-DSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLP---CFRGQTINLLKQRFVA 2115

Human  1064 GKTEEEALKHFRVKFNEALRESWK 1087
            .|..:||..|...    .:|.|::
  Fly  2116 TKNNKEAAAHMLA----VIRNSYQ 2135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	XP_016856965.1	PI3K_p85B	32..107	CDD:308030	15/81 (19%)
		PI3K_rbd	175..281	CDD:307097	25/129 (19%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	42/240 (18%)
		PI3Ka	562..743	CDD:214537	49/287 (17%)
		PI3Kc_IA_delta	735..1101	CDD:270718	99/388 (26%)
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	35/182 (19%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	86/318 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810