Protein Alignment PIK3CD and pik3

DIOPT Version :10

• Sequence 1: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_594699.1
• Gene: pik3 / 2543444
• PomBaseID: SPAC458.05
• Length: 801
• Species: Schizosaccharomyces pombe
• Alignment Length: 831
• Identity: 224/831 - (26%)
• Similarity: 370/831 - (44%)
• Gaps: 166/831 - (19%)

Human   331 SKVNA------------DERMKLVVQAGLFHGNE-----MLC-------KTVSSSEVSVCSEPVW 371
            |||.|            |.:...:....||.|||     ..|       |::..:|:|..|...|
pombe    12 SKVTARFLVKFCFIEYQDSQEPCICTIQLFSGNESGSLMQKCFVSKIPNKSLLPTELSKISTHEW 76

Human   372 KQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGE 436
               |:|.:.:.:|...|:.      |:...|.:.:.::..:...|    ....|||..:.|:.|
pombe    77 ---LDFGVTVSELSLNAKF------VVSAWKPSFNDEEVYEFVGC----TTYRLFDENNLLRQG- 127

Human   437 RCLYMWPSVPDEKGELLNPT----------------------GTVRSNPNTD-----------SA 468
              |...|....::.:..:||                      |.|.|....|           |.
pombe   128 --LQKIPLQTSKEIKKYSPTSLELEQVKEINRLDGLLLKLQLGDVPSVNWLDDISFGKIKDFRSK 190

Human   469 AALLICLPEV--------------------APHPVYYPALEKILELGRHSECVH----------- 502
            ...|:.:|.:                    :.:.|||.:.:..|.|...:|..|
pombe   191 HMSLVTIPILYLDFLQFSFPVVFQRSYYPKSENRVYYSSFDLELNLDSPAELKHRRLVRSQRNGP 255

Human   503 ------VTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDV 561
                  ...:.:.:|..||....|.||...||||:||.|..:..: .:|:.:.|....|....:|
pombe   256 LDKDLKPNSKIRKELESILSYPPSEELSLEEKDLIWKFRFYLTRN-KKAMTKFLKSVVWTDSSEV 319

Human   562 AQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKYESYLD 626
            .|.|.||.||.|:.:..|||||..||....|.::|:..|...:::||..|||||||.|:|::.:.
pombe   320 NQALSLLDSWTEIDIDDALELLSPSFVHPKVRAYAVSRLETASNEELLLYLLQLVQALRYDNPIS 384

Human   627 CE-------LTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHM----- 679
            .:       |..||::||:::..||:.|:|:|..|:....|:..|..::..:.:..:..:
pombe   385 SDERFQPSPLALFLVNRAISSPSIGNDLYWYLVVEIEDEPVSKLFSSVMFLFQKELSKSVEGRLI 449

Human   680 -KVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAE 743
             :.|..|.:.:.||..::..|: |.:.|...:.:.|..|....:.:|.....|..|||||..:..
pombe   450 RETLSAQAKFVEKLLRISKSVQ-SFRGTRLKKIEYLKVLLEDHKYHLLDFHALPLPLDPSVNIVG 513

Human   744 VCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDL 808
            :..:.||...|.|:||.:::..::   |....||||||||||||.|.:|::.|||.|.|:|.|||
pombe   514 IIPDACTVFKSTMQPLRLLFKCQD---GSKYPIIFKNGDDLRQDQLVIQILTLMDKLLKKEKLDL 575

Human   809 RMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDR--- 870
            .:.||..|.||...|.::.| .|.|:|.|          .|....::|.:|:..||.:.|:.
pombe   576 HLKPYRILATGPTHGAVQFV-PSKTLATI----------LAEYHGSVLAYLRENNPDDGLNSANY 629

Human   871 -----AIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGN----FKTKFGIN 926
                 |::.:..|||||||.||:||:||||.||::|.:.|..||.|||:.||.    |.....::
pombe   630 GIDPVAMDNYVRSCAGYCVITYLLGVGDRHLDNLLITKDGHFFHADFGYILGRDPKLFSPAMKLS 694

Human   927 RERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSC 991
            :|.|..:..|            ||..:::|:.||...:|.||:...|.|:||:||..|.:|::..
pombe   695 KEMVEGMGGY------------NSPFYQQFKSYCYTTFTALRKSSNLILNLFSLMVDANIPDIKF 747

Human   992 SKD--IQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNVSK 1040
            .|:  :..:|:...|..:|.:|:|:|....|:::...:...::.: ||:::
pombe   748 DKEKVVYKVKERFCLQMSESDAIKYFEQLINDSVSALFPQIIDRM-HNLAQ 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483
		PI3K_rbd	175..281	CDD:395642
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	39/226 (17%)
		PI3Ka	503..684	CDD:214537	59/193 (31%)
		PI3Kc_IA_delta	676..1042	CDD:270718	120/385 (31%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		1/5 (20%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		5/7 (71%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		9/29 (31%)
pik3	NP_594699.1	TEL1	<1..801	CDD:227365	224/831 (27%)
		PI3Kc_III	450..797	CDD:270628	120/374 (32%)