Protein Alignment PIK3CD and Pik3cd

DIOPT Version :10

• Sequence 1: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Sequence 2: XP_006538704.1
• Gene: Pik3cd / 18707
• MGIID: 1098211
• Length: 1074
• Species: Mus musculus
• Alignment Length: 1074
• Identity: 988/1074 - (91%)
• Similarity: 1015/1074 - (94%)
• Gaps: 30/1074 - (2%)

Human     1 MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGP 65
            ||||||||||||||||:||||||||||||||||||||||||||||||:|||||||||||||||.|
Mouse     1 MPPGVDCPMEFWTKEESQSVVVDFLLPTGVYLNFPVSRNANLSTIKQVLWHRAQYEPLFHMLSDP 65

Human    66 EAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDS 130
            |||||||:||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse    66 EAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDS 130

Human   131 LCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNRALLVNVK 195
            |.||||||||.||.||||||||.||||||..||||||||||||||:.|..|.||:.|||||||||
Mouse   131 LRDPEVNDFRTKMRQFCEEAAAHRQQLGWVEWLQYSFPLQLEPSARGWRAGLLRVSNRALLVNVK 195

Human   196 FEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYTLQVNGRHEYLYGSYPLCQFQ 260
            ||||||||||||||||:|||||||||||||||||||||||||:|.||||||||||||:||||.||
Mouse   196 FEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVEQPEEYALQVNGRHEYLYGNYPLCHFQ 260

Human   261 YICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFRI 325
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Mouse   261 YICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPIPAKKPSSVSLWSLEQPFSI 325

Human   326 ELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVSVCSEPVWKQRLEFDINICDLPRMARL 390
            |||:|.||||||||||||||||||||||||||||||||:|||||||||||||||::|||||||||
Mouse   326 ELIEGRKVNADERMKLVVQAGLFHGNEMLCKTVSSSEVNVCSEPVWKQRLEFDISVCDLPRMARL 390

Human   391 CFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNP 455
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 CFALYAVVEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNP 455

Human   456 TGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGS 520
            .||||.||||:|||||:|.||||||||||:||||||||||||.|...:|||||||||||||||||
Mouse   456 AGTVRGNPNTESAAALVIYLPEVAPHPVYFPALEKILELGRHGERGRITEEEQLQLREILERRGS 520

Human   521 GELYEHEKDLVWKLRHEVQEHFPEALARLLLVTKWNKHEDVA----------------------- 562
            |||||||||||||:||||||||||||||||||||||||||||
Mouse   521 GELYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQVSREGGSGRQPRGRWTVPAHPY 585

Human   563 ------QMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKY 621
                  ||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||
Mouse   586 LTTKLSQMLYLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQLVQVLKY 650

Human   622 ESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQG 686
            |||||||||||||.||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse   651 ESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFGLIMEAYCRGSTHHMKVLMKQG 715

Human   687 EALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVC-VEQCT 750
            ||||||||||||||:|||||.||||||:||:|||||.|:||||||||||||||||.||| |||||
Mouse   716 EALSKLKALNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEVCSVEQCT 780

Human   751 FMDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGC 815
            ||||||||||||||:|||||.|:||||||||||||||||||||||||||||||||||||||||||
Mouse   781 FMDSKMKPLWIMYSSEEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGC 845

Human   816 LPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCA 880
            ||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   846 LPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCA 910

Human   881 GYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQG 945
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   911 GYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQG 975

Human   946 KTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEE 1010
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   976 KTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEE 1040

Human  1011 ALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ 1044
            ||||||||||||||||||||||||||||||||||
Mouse  1041 ALKHFRVKFNEALRESWKTKVNWLAHNVSKDNRQ 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483	68/72 (94%)
		PI3K_rbd	175..281	CDD:395642	93/105 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312		24/24 (100%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	154/166 (93%)
		PI3Ka	503..684	CDD:214537	175/209 (84%)
		PI3Kc_IA_delta	676..1042	CDD:270718	354/366 (97%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		7/7 (100%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		25/25 (100%)
Pik3cd	XP_006538704.1	PI3K_p85B	34..107	CDD:460483	68/72 (94%)
		PI3K_rbd	182..281	CDD:395642	90/98 (92%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	154/166 (93%)
		PI3Ka	504..713	CDD:214537	175/208 (84%)
		PI3Kc_IA_delta	705..1072	CDD:270718	354/366 (97%)