Protein Alignment PIK3CD and age-1

DIOPT Version :10

• Sequence 1: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_496462.2
• Gene: age-1 / 174762
• WormBaseID: WBGene00000090
• Length: 1182
• Species: Caenorhabditis elegans
• Alignment Length: 1206
• Identity: 330/1206 - (27%)
• Similarity: 520/1206 - (43%)
• Gaps: 240/1206 - (19%)

Human     3 PGVDCPMEFWTKEENQSV---------------VVDF--LLPTGVYLN--FP-------VSRNAN 41
            |.:...:|.|...|..|:               |.|.  :.|.|..::  ||       .|....
 Worm    44 PQLQTMVEQWQMRERPSLETENGKGSLLLENEGVADIITMCPFGEVISVVFPWFLANVRTSLEIK 108

Human    42 LSTIKQLLWHRAQYEPLFHMLSG-----PEAYVFTCINQTAEQQEL--EDEQRRLCDVQPFLPVL 99
            ||..|..|     :|.:..|..|     |:.|||..:|...|.:.:  :|:.....::....|:|
 Worm   109 LSDFKHQL-----FELIAPMKWGTYSVKPQDYVFRQLNNFGEIEVIFNDDQPLSKLELHGTFPML 168

Human   100 RLVAREGDRVKKLINSQISLLIGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQ 164
            .|...:|....|.:.|.||..:|..|.:.:...|.|:..|||.:....::....|   |.|....
 Worm   169 FLYQPDGINRDKELMSDISHCLGYSLDKLEESLDEELRQFRASLWARTKKTCLTR---GLEGTSH 230

Human   165 YSFPLQ------------LEPSAQT--------WGPGTLRLP---NRALLVNVKFEGSEESFTFQ 206
            |:||.:            ||...:.        |......:.   .:.:.:.::|..:|
 Worm   231 YAFPEEQYLCVGESCPKDLESKVKAAKLSYQMFWRKRKAEINGVCEKMMKIQIEFNPNE------ 289

Human   207 VSTKDVPLALMACAL--RKKATVFRQPLVEQPED--YTLQVNGRHEYLYG-SYPLCQFQYICSCL 266
                 .|.:|:...|  .:|..|:.   .:.|.|  :.||:.||..::.. ...|..:..:.|.|
 Worm   290 -----TPKSLLHTFLYEMRKLDVYD---TDDPADEGWFLQLAGRTTFVTNPDVKLTSYDGVRSEL 346

Human   267 HSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPI------------------------- 306
            .|...|...:...|.:|              |...:|.|:
 Worm   347 ESYRCPGFVVRRQSLVL--------------KDYCRPKPLYEPHYVRAHERKLALDVLSVSIDST 397

Human   307 ---------------PAKKPSSVSLWSLEQPFRIE--LIQGSKVNADERMKLVVQAGLFHGNEML 354
                           |......||||.|:....|.  .|.|....||..|.:.::..::.|...|
 Worm   398 PKQSKNSDMVMTDFRPTASLKQVSLWDLDANLMIRPVNISGFDFPADVDMYVRIEFSVYVGTLTL 462

Human   355 CKTVSSSEVSVCSE-PVW-KQRLEFDINICDLPRMARLCF-ALYAVIEKAKKARSTKKKSKKADC 416
               .|.|...|.:: ..| |:...||:.:.|:|..|.|.. .||.           |.|.|..:.
 Worm   463 ---ASKSTTKVNAQFAKWNKEMYTFDLYMKDMPPSAVLSIRVLYG-----------KVKLKSEEF 513

Human   417 PIAWANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPH 481
            .:.|.|:.|.|::|:|:.|:...::|...|......:...|   :...|::|..:     |::.:
 Worm   514 EVGWVNMSLTDWRDELRQGQFLFHLWAPEPTANRSRIGENG---ARIGTNAAVTI-----EISSY 570

Human   482 --PVYYPALEKILELGRH---------------SECVHVTEEEQLQLREILERRGSG-ELYEHEK 528
              .|..|:..:...|.:|               ..|:.....::||:  ::::..|| .|.|.|:
 Worm   571 GGRVRMPSQGQYTYLVKHRSTWTETLNIMGDDYESCIRDPGYKKLQM--LVKKHESGIVLEEDEQ 633

Human   529 DLVWKLRHEVQEHFPEALARLL-LVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHV 592
            ..||..|..:|:..|:.|..|. |...|...|:.:::..:|..|....|.:||.||.....|..:
 Worm   634 RHVWMWRRYIQKQEPDLLIVLSELAFVWTDRENFSELYVMLEKWKPPSVAAALTLLGKRCTDRVI 698

Human   593 GSFAIKSLRKLTDDELFQ-YLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEM- 655
            ..||::.|.:......|. ::|.|:|.||||.....|:...||.|||.:.:|||.|||.||:|:
 Worm   699 RKFAVEKLNEQLSPVTFHLFILPLIQALKYEPRAQSEVGMMLLTRALCDYRIGHRLFWLLRAEIA 763

Human   656 HVPSVAL------RFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKEL 714
            .:....|      |..|::|||.||:..|:|::.:|.:.:.:|..::..|        |...|::
 Worm   764 RLRDCDLKSEEYRRISLLMEAYLRGNEEHIKIITRQVDMVDELTRISTLV--------KGMPKDV 820

Human   715 MHLCMRQEAYLEALSH----LQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSV- 774
            ..:.:|.|  |.::||    :.|||||...|.|:.:::...:.|..:||.:.:.|:...|...:
 Worm   821 ATMKLRDE--LRSISHKMENMDSPLDPVYKLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLP 883

Human   775 --GIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANI 837
              .:|||||||||||||.||::::||.:||...:|..:.||..||.|:..|:||||....||..|
 Worm   884 FCAMIFKNGDDLRQDMLVLQVLEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEI 948

Human   838 QLNKSNM-AATAAFNKDALLNWLK----------------SKNPGE-ALD---------RAIEEF 875
            |:....| .|..:.:...:..|::                :|||.| .:|         .:::.|
 Worm   949 QVGTGFMNTAVRSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRF 1013

Human   876 TLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVH 940
            ..||.||.||||::||.||||||:|:.|.|:.|||||||.||:.|||.||.|:|.|||||..|:.
 Worm  1014 LYSCVGYSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMT 1078

Human   941 VIQQGKT--NNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSL- 1002
            ||:.||:  .||.:.::|:..|..||.::..:..||:.||.||....|||||...|:.:||.:|
 Worm  1079 VIRSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVSLFTLMLGMELPELSTKADLDHLKKTLF 1143

Human  1003 ALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNV 1038
            ..|:::|||.|.|...:.||...||.||.|||.|.|
 Worm  1144 CNGESKEEARKFFAGIYEEAFNGSWSTKTNWLFHAV 1179

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483	20/86 (23%)
		PI3K_rbd	175..281	CDD:395642	19/121 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312		4/64 (6%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	42/171 (25%)
		PI3Ka	503..684	CDD:214537	61/190 (32%)
		PI3Kc_IA_delta	676..1042	CDD:270718	150/400 (38%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		1/5 (20%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		6/7 (86%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		18/25 (72%)
age-1	NP_496462.2	PI3K_p85B	98..177	CDD:197539	19/83 (23%)
		PI3K_rbd	241..360	CDD:197540	21/132 (16%)
		C2_PI3K_like	420..574	CDD:176026	42/175 (24%)
		PI3Ka	606..798	CDD:214537	62/193 (32%)
		Protein Kinases, catalytic domain	793..1181	CDD:473864	149/397 (38%)