Protein Alignment PIK3CD and pik3ca

DIOPT Version :10

• Sequence 1: NP_005017.3
• Gene: PIK3CD / 5293
• HGNCID: 8977
• Length: 1044
• Species: Homo sapiens
• Sequence 2: NP_001119972.1
• Gene: pik3ca / 100144924
• XenbaseID: XB-GENE-998106
• Length: 1065
• Species: Xenopus tropicalis
• Alignment Length: 1092
• Identity: 438/1092 - (40%)
• Similarity: 629/1092 - (57%)
• Gaps: 99/1092 - (9%)

Human     1 MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFHMLSGP 65
            |||               .::|:.|||.|:.:.....|.|.|..||..|:..|:..||:|:|...
 Frog    16 MPP---------------RILVECLLPNGMVVVLECLREATLVNIKHELFKEARKYPLYHLLQDE 65

Human    66 EAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLLIGKGLHEFDS 130
            .:|:|..:.|.||::|..||.|||||::.|.|.|::|...|:|.:|::|.:|...||..:.|||.
 Frog    66 SSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVVEPVGNREEKILNREIGFAIGMPVCEFDM 130

Human   131 LCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGPGTLRLPNR------- 188
            :.|.||.|||..:...|:::...|...|..:...|.:|..:|.|::        ||..
 Frog   131 VKDSEVQDFRKNILNVCKDSVELRDANGPISRALYVYPPNVESSSE--------LPKHIESKLDK 187

Human   189 -----ALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKK-------ATVFRQPLVEQPEDYTL 241
                 .:.|.|.....::.::.:::...||..::|.|:|||       :...:..::|....|.|
 Frog   188 GQIIVVIWVIVSPNNEKQKYSLKINHDCVPEHVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYIL 252

Human   242 QVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRAKPPPI 306
            :|.|..|||...|||.|::||.||:..|..|:|.::...|:.:.........|...:..:...|.
 Frog   253 KVCGCDEYLLEKYPLSQYKYIRSCIMLGRMPNLMLMAKDSLYSQIPVDVFTMPSYSRRISTAAPY 317

Human   307 PAKKPSSVSLWSLEQPFRIELIQGSKVNADER--MKLVVQAGLFHGNEMLCKTVSSSEVSVCSEP 369
            ...:.|:.|||::....||:::..:.||.:.|  .|:.|:.|::||.|.||..|::..|. ||.|
 Frog   318 MNGEASAKSLWAINSTLRIKILCATYVNVNIRDIDKIYVRTGIYHGVEPLCDNVNTQRVP-CSNP 381

Human   370 VWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAWANLMLFDYKDQLKT 434
            .|.:.|.:|:.|.||||.||||.::.:|     |.|   |.:|:..||:||.|:.||||.|.|.:
 Frog   382 RWNEWLLYDMFIPDLPRAARLCLSICSV-----KGR---KGAKEEHCPLAWGNINLFDYTDTLVS 438

Human   435 GERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLP---EVAPHPVYYP---ALE---- 489
            |:..|.:|| ||....:||||.|...||||.::.     ||.   :....||.:|   |:|
 Frog   439 GKMALNLWP-VPHGLEDLLNPIGVSGSNPNKETP-----CLELEFDCFSSPVKFPDMTAIEDHAN 497

Human   490 KILE---------------LGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQ 539
            |:||               :.|.:|   |.|.::.||:.|..|....|:.|.||:.:|.  |.:.
 Frog   498 KVLEREMGYNYSHSGLSNRIVRENE---VRESDKEQLKAISNRDPLSEITEQEKEFLWS--HRLY 557

Human   540 -EHFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSLRK- 602
             .:.||.|.:|||..|||..:||:||..||..||.:....|:|||||::||..|.|||:..|.|
 Frog   558 CRNIPEILPKLLLSVKWNCRDDVSQMYCLLKEWPAIRPEQAMELLDFNYPDRIVRSFAVSCLEKY 622

Human   603 LTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLI 667
            ||||:|.|||:|||||:|||.|||..|.:|||.:||.|::||||.||.|:||||..:|:.||||:
 Frog   623 LTDDKLSQYLIQLVQVMKYEQYLDNHLVRFLLKKALVNQRIGHFFFWLLKSEMHNKTVSQRFGLL 687

Human   668 LEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQ-KTPKPQTKELMHLCMRQEAYLEALSHL 731
            ||:|||....::|.|.||.||:.||..|.|.:|...: :|.|.|.|.|:.. |::..:::||...
 Frog   688 LESYCRACGMYLKHLSKQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQ-MKRPDFMDALQGF 751

Human   732 QSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGG---SVGIIFKNGDDLRQDMLTLQM 793
            .|||:|:..|..:.:|:|..|.|..:|||:.:.|.:..|..   :..|||||||||||||||||:
 Frog   752 TSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSEMLFLNNEIIFKNGDDLRQDMLTLQI 816

Human   794 IQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNW 858
            |::|:.:|:.:||||||.|||||..||..||||||..|.||..||. |..:.....||...|..|
 Frog   817 IRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRCSHTIMQIQC-KGGLKGALQFNSHTLHQW 880

Human   859 LKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKF 923
            ||.||.||..|.||:.||.|||||||||::|||||||:.|||::::||||||||||||.:.|.||
 Frog   881 LKDKNKGETYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDNGQLFHIDFGHFLDHKKKKF 945

Human   924 GINRERVPFILTYDFVHVIQQG--KTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGL 986
            |..||||||:||.||:.||.:|  :...:..||||:..|.:||..:|:|..||::||::|..:|:
 Frog   946 GYKRERVPFVLTQDFLIVISKGIQECTKTRDFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGM 1010

Human   987 PELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWKTKVNWLAHNV 1038
            |||....||.|::.:|||.|||:|||::|..:.|:|....|.||::|:.|.:
 Frog  1011 PELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTI 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CD	NP_005017.3	PI3K_p85B	34..107	CDD:460483	28/72 (39%)
		PI3K_rbd	175..281	CDD:395642	30/124 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..312		2/24 (8%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	66/171 (39%)
		PI3Ka	503..684	CDD:214537	92/182 (51%)
		PI3Kc_IA_delta	676..1042	CDD:270718	179/369 (49%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	751..757		2/5 (40%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	890..898		6/7 (86%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	909..935		18/25 (72%)
pik3ca	NP_001119972.1	PI3K_p85B	34..107	CDD:460483	28/72 (39%)
		PI3K_rbd	173..292	CDD:413336	31/126 (25%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	66/173 (38%)
		PI3Ka_I	525..696	CDD:238444	89/172 (52%)
		Protein Kinases, catalytic domain	695..1064	CDD:473864	179/370 (48%)