DRSC/TRiP Functional Genomics Resources

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Protein Alignment PIK3CB and VPS34

DIOPT Version :10

Sequence 1:NP_006210.1 Gene:PIK3CB / 5291 HGNCID:8976 Length:1070 Species:Homo sapiens
Sequence 2:NP_013341.1 Gene:VPS34 / 850941 SGDID:S000004230 Length:875 Species:Saccharomyces cerevisiae


Alignment Length:886 Identity:222/886 - (25%)
Similarity:352/886 - (39%) Gaps:229/886 - (25%)


- Green bases have known domain annotations that are detailed below.


Human   306 RNSSN----LPLPLPPKKTRIISH----VWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTE 362
            |||..    |.||:..|:....||    :||.|...||..     .|.|.::             
Yeast    83 RNSRTWDYWLTLPIRIKQLTFSSHLRIILWEYNGSKQIPF-----FNLETSI------------- 129

Human   363 LLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDK---VKTKKSTKTINPSK 424
                                    |::..|.|.|........|.|:|.   |...|..:.:|  |
Yeast   130 ------------------------FNLKDCTLKRGFESLKFRYDVIDHCEVVTDNKDQENLN--K 168

Human   425 Y-------------QTIRKAGKVHYPVAW-VNTMVFDFKGQLRTGDIILHSWSSFPDELEEMLNP 475
            |             .||.|..|......| ..|.|.:.:..:....::.         :|..:  
Yeast   169 YFQGEFTRLPWLDEITISKLRKQRENRTWPQGTFVLNLEFPMLELPVVF---------IEREI-- 222

Human   476 MGTVQTNPYTENATALHVKFPE-NKKQPY--------------YYPP----FDKIIEKAAEI-AS 520
            |.|....|..:|...|.....| |:..|.              :|.|    .|.|.||...: .:
Yeast   223 MNTQMNIPTLKNNPGLSTDLREPNRNDPQIKISLGDKYHSTLKFYDPDQPNNDPIEEKYRRLERA 287

Human   521 SDSANVSSRGGKKFLPVLK------EILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLS 579
            |.:||:.    |:..|.:|      :|::..|.::|..:|...||..|..... ..::|.|||.|
Yeast   288 SKNANLD----KQVKPDIKKRDYLNKIINYPPGTKLTAHEKGSIWKYRYYLMN-NKKALTKLLQS 347

Human   580 IKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQ 644
            ....:..:..::..|:..|.::...:|||||...:.:..||.|||..|::.||:||..||||||:
Yeast   348 TNLREESERVEVLELMDSWAEIDIDDALELLGSTFKNLSVRSYAVNRLKKASDKELELYLLQLVE 412

Human   645 VLKYE--------------------------------------------------------PFLD 653
            .:.:|                                                        |.:.
Yeast   413 AVCFENLSTFSDKSNSEFTIVDAVSSQKLSGDSMLLSTSHANQKLLKSISSESETSGTESLPIVI 477

Human   654 CALSRFLLERALGNRRIGQFLFWHLRSE----VHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVE 714
            ..|:.||:.|||.|.|:|.|.:|:|:||    .::..:...|...|:...|      .:|:.||.
Yeast   478 SPLAEFLIRRALVNPRLGSFFYWYLKSESEDKPYLDQILSSFWSRLDKKSR------NILNDQVR 536

Human   715 ALNKLKTLNSLIKLNAVKLNRAKGKEAM-HTCLKQSAYREALS--DLQSPLNPCVILSELYVEKC 776
            .:|.|:.....||  .:|...||..|.: |  |.::..|..:.  .:..||:|.|::.::..|..
Yeast   537 LINVLRECCETIK--RLKDTTAKKMELLVH--LLETKVRPLVKVRPIALPLDPDVLICDVCPETS 597

Human   777 KYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGC 841
            |...|.:.||.:.:...:  .....::||.|||||||.|.:|::.||:.|.|...:||::.||..
Yeast   598 KVFKSSLSPLKITFKTTL--NQPYHLMFKVGDDLRQDQLVVQIISLMNELLKNENVDLKLTPYKI 660

Human   842 LATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNK-DALLNWLKEYNSGDDLDRAI-----EE 900
            ||||.:.|.||.: .::|:|.|            .:| ..:|.:||.:...::....:     :.
Yeast   661 LATGPQEGAIEFI-PNDTLASI------------LSKYHGILGYLKLHYPDENATLGVQGWVLDN 712

Human   901 FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFI 965
            |..|||||||.:|:||:||||.||::|...|..||.|||:|||.....|....:..|        
Yeast   713 FVKSCAGYCVITYILGVGDRHLDNLLVTPDGHFFHADFGYILGQDPKPFPPLMKLPP-------- 769

Human   966 HVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD--IQYLKDSL 1028
            .:|:......:..:.:||..|..||.||||:..|.:.||.||.|:.:|::....:  |..:::..
Yeast   770 QIIEAFGGAESSNYDKFRSYCFVAYSILRRNAGLILNLFELMKTSNIPDIRIDPNGAILRVRERF 834

Human  1029 ALGKSEEEALKQFKQKFDEA--------------LRESWTT 1055
            .|..|||:|...|:...:::              |.:.|.|
Yeast   835 NLNMSEEDATVHFQNLINDSVNALLPIVIDHLHNLAQYWRT 875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PIK3CBNP_006210.1 PI3K_p85B 41..118 CDD:197539
PI3K_rbd 180..288 CDD:197540
C2_PI3K_class_I_beta_delta 324..501 CDD:176075 36/198 (18%)
Nuclear localization signal 410..418 2/10 (20%)
PI3Ka_I 532..702 CDD:238444 57/235 (24%)
PI3Kc_IA_beta 706..1067 CDD:270717 112/375 (30%)
G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 778..784 1/5 (20%)
Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 916..924 5/7 (71%)
Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 935..961 9/25 (36%)
VPS34NP_013341.1 TEL1 <1..872 CDD:227365 220/881 (25%)
PI3Kc_III 528..871 CDD:270628 111/375 (30%)
Blue background indicates that the domain is not in the aligned region.

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