Protein Alignment PIK3CB and pik3cb

DIOPT Version :10

• Sequence 1: NP_006210.1
• Gene: PIK3CB / 5291
• HGNCID: 8976
• Length: 1070
• Species: Homo sapiens
• Sequence 2: NP_001072928.1
• Gene: pik3cb / 780390
• XenbaseID: XB-GENE-482674
• Length: 1065
• Species: Xenopus tropicalis
• Alignment Length: 1076
• Identity: 824/1076 - (76%)
• Similarity: 945/1076 - (87%)
• Gaps: 23/1076 - (2%)

Human     7 MPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNL 71
            |||.| |.:|||..|:.:..|  |.||.|||||||:|::|||:|:||:|||:|||...:||:|:|
 Frog     1 MPPIM-DHMDIWTADTPLPPD--ICVDVLLPTGIYVQMDVPRDASISHIKQLLWKHAQSYPLFHL 62

Human    72 LMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKIGVLIGKGLHE 136
            |::||||||.|||..||:|||||||:|||||||||||||||:|||:|.|||||||||||||||.|
 Frog    63 LLEIDSYMFQCVNHNAVHEELEDETQRLCDVRPFLPVLKLVSRSCNPAEKLDSKIGVLIGKGLQE 127

Human   137 FDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVAV 201
            ||:|||.||.|||.|||..||.||.||:||:|::|||:|:|||.||||.:|::.|||||.::||:
 Frog   128 FDALKDNEVMEFRSKMRSISEAKIQSLLGLTWVEWLKRTFPPELEPSIQDNIQGKLYGGNIVVAI 192

Human   202 HFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKE-DEVSPYDYVLQVSGRVEYVFGDHPLIQ 265
            |||||||||||||||||.|:|||||||:|||||||:| :||.|.|:||||:||:|:|||||||||
 Frog   193 HFENCQDVFSFQVSPNMVPVKVNELAIRKRLTIHGREAEEVDPEDFVLQVNGRLEFVFGDHPLIQ 257

Human   266 FQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSS---NLPLPLPPKK-------T 320
            ||||||||||:||||..|||||.|||:::|||..||.|:.|.||   .||:||||||       .
 Frog   258 FQYIRNCVMNKALPHLTLVECCNIKKLFDQEMSEIEHAVRRKSSMHPALPMPLPPKKRGASMKTL 322

Human   321 RIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPL 385
            .:...||....|::|:|.||::||||::|.  ||||||||||||||..::.||.|||||:|||.|
 Frog   323 NMRDIVWNIVQPYKIILSKGSRLNTEDSVL--VRAGLFHGTELLCKPTMTPEVQGKNDHVWNETL 385

Human   386 EFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKG 450
            ||:||:||||||||||||:||||||.:.|      |.:|||||:|:||:|:|||||||||||:||
 Frog   386 EFEINVCDLPRMARLCFAIYAVLDKPRNK------NKTKYQTIKKSGKMHFPVAWVNTMVFDYKG 444

Human   451 QLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKA 515
            |||:||.:||.||||||||||||||||||:|||||||.|.||:||.:..|:|..|||||||:|||
 Frog   445 QLRSGDHVLHCWSSFPDELEEMLNPMGTVRTNPYTENTTTLHIKFHDYSKEPISYPPFDKILEKA 509

Human   516 AEIA-SSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLS 579
            |||| :|||.:.|.|||||....||||::||||.||.|||.|||||||.||||.||.||||||||
 Frog   510 AEIARNSDSLSTSGRGGKKLNIELKEIMERDPLCQLSENEKDLIWTLRYDCRENFPGSLPKLLLS 574

Human   580 IKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQ 644
            :||||||||||||||||||.|||||:|||||||||||||||||||.||:.|||||||||||||||
 Frog   575 VKWNKLEDVAQLQALLQIWSKLPPRDALELLDFNYPDQYVREYAVNCLKPMSDEELSQYLLQLVQ 639

Human   645 VLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVL 709
            |||||||||||||||||:|||.|||||||||||||||||.||||||||::|||||||||.|||||
 Frog   640 VLKYEPFLDCALSRFLLQRALDNRRIGQFLFWHLRSEVHNPAVSVQFGLLLEAYCRGSVAHMKVL 704

Human   710 SKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVE 774
            |:||||||||:|||.|||||||||::.|.|:.|||||:::||:|||..:||||||.:.||||.||
 Frog   705 SRQVEALNKLRTLNGLIKLNAVKLSKVKNKDNMHTCLRENAYKEALMHIQSPLNPSITLSELVVE 769

Human   775 KCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPY 839
            |||||||||||||:||||:.||.||:|:|||||||||||||.||:|||||:||||||||||::||
 Frog   770 KCKYMDSKMKPLWIVYNNRGFGSDSLGIIFKNGDDLRQDMLALQLLRLMDMLWKEAGLDLRIVPY 834

Human   840 GCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLS 904
            ||||||||.|.|||||.:||||||||:|||:||||||||||||||:||.:|||||:|||||||||
 Frog   835 GCLATGDRCGFIEVVSAAETIADIQLDSSNLAAAAAFNKDALLNWIKECHSGDDLERAIEEFTLS 899

Human   905 CAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQ 969
            |||||||:|||||||||:|||||:|||||||||||||||||||||.|||||.|||||||||||||
 Frog   900 CAGYCVATYVLGIGDRHNDNIMVRKTGQLFHIDFGHILGNFKSKFKIKRERGPFILTYDFIHVIQ 964

Human   970 QGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSE 1034
            |||.||||||||||||||||||||||:|||.|||||||||||||||:|||||||:||||||||.|
 Frog   965 QGKPGNTEKFGRFRQCCEDAYLILRRNGNLIITLFALMLTAGLPELSSVKDIQYVKDSLALGKKE 1029

Human  1035 EEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS 1070
            |:|||||:|||||||:|||||||||||||:||||::
 Frog  1030 EDALKQFRQKFDEALKESWTTKVNWMAHTMRKDYKA 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CB	NP_006210.1	PI3K_p85B	41..118	CDD:197539	55/76 (72%)
		PI3K_rbd	180..288	CDD:197540	83/108 (77%)
		C2_PI3K_class_I_beta_delta	324..501	CDD:176075	120/176 (68%)
		Nuclear localization signal	410..418		2/7 (29%)
		PI3Ka_I	532..702	CDD:238444	146/169 (86%)
		PI3Kc_IA_beta	706..1067	CDD:270717	304/360 (84%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	778..784		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	916..924		6/7 (86%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	935..961		23/25 (92%)
pik3cb	NP_001072928.1	PI3K_p85B	35..108	CDD:460483	52/72 (72%)
		PI3K_rbd	172..279	CDD:197540	82/106 (77%)
		C2_PI3K_class_I_beta_delta	328..495	CDD:176075	120/174 (69%)
		PI3Ka_I	533..697	CDD:238444	144/163 (88%)
		PI3Kc_IA_beta	701..1062	CDD:270717	304/360 (84%)