DRSC/TRiP Functional Genomics Resources

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Protein Alignment PIK3CB and Pi3K59F

DIOPT Version :10

Sequence 1:NP_006210.1 Gene:PIK3CB / 5291 HGNCID:8976 Length:1070 Species:Homo sapiens
Sequence 2:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster


Alignment Length:947 Identity:232/947 - (24%)
Similarity:370/947 - (39%) Gaps:295/947 - (31%)


- Green bases have known domain annotations that are detailed below.


Human   337 LVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLC 401
            :::.:.|.:||.....||..:|:.....|..:.||..:......|||.:...:...||||.|.| 
  Fly    44 ILRFSGLYSEEHPSFQVRLQVFNQGRPYCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAML- 107

Human   402 FAVYAVLD-------------------------------KV----------------KTKKSTKT 419
              |..:||                               :|                |.|:|:| 
  Fly   108 --VLTILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGNFPSRTPGKGKESSK- 169

Human   420 INPSKYQTIRKAGKVH-----YPVAWVNTMVFDFKGQLRTGDIILHSWSSFPDEL---------- 469
               |:.|.:.|..|.|     ..|.|::.:.|      |..::|........|.:          
  Fly   170 ---SQMQRLGKLAKKHRNGQVQKVDWLDRLTF------REIEVINEREKRMSDYMFLMIEFPAIV 225

Human   470 -EEMLN-------PMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIE-KAAEIASSDSAN 525
             ::|.|       |.|.|:   |...|....|..|:::.|      .:.::| |...:|.|:.:.
  Fly   226 VDDMYNYAVVYFEPEGDVK---YKLPAKPKLVSVPDSEIQ------MENLVERKHHRLARSERSG 281

Human   526 VSSRGGKKFLPV---LKEILDR-DPLSQLCENEMDLIWTLRQDCREIF-----PQSLPKLLLSIK 581
            :|.|..|....:   |..|:.| .|...|...|.||:|..|      |     .::|.|.|..|.
  Fly   282 ISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFR------FYLSSHKKALTKFLKCIN 340

Human   582 WNKLED-VAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQV 645
            | |||| |.|...:|..|..:...:|||||...:....||:|||..|.|..||:|..|||||||.
  Fly   341 W-KLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDLLLYLLQLVQA 404

Human   646 LKYE---------------------------PFLD------------------------------ 653
            ||||                           ..||                              
  Fly   405 LKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLDQSSLSDLSATSSGLHGSVIPANQRAASVLA 469

Human   654 -------------------------------------------------------------CALS 657
                                                                         ..|.
  Fly   470 AIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNALMLAEGISFGSVPANLC 534

Human   658 RFLLERALGNRRIGQFLFWHLRSEV-HIPAVSVQ-------FGVILEAYCRGSVGHMKVLSKQVE 714
            .||::||..|..:..:.:|:|..|| .:.:|..|       :.::|:.:       :|||.....
  Fly   535 TFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMF-------LKVLENGNF 592

Human   715 ALNKL--------KTLNSLIKLNAVKL------NRAKGKEAMHTCL-KQSAYREALSDLQS---P 761
            .|..:        :.::.|:||  |||      ||.|..|.....| :|..::...::.:.   |
  Fly   593 NLRGIFYNLRKQRRFIDELVKL--VKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTNFEPIPFP 655

Human   762 LNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLL 826
            |:|.:.::::...:.....|.:.|..|.:...: .......|||:|||||||.|.|||:.|||.|
  Fly   656 LDPEIYITKIVPMRTSLFKSALMPAKLTFVTSI-AHHEYAAIFKHGDDLRQDQLILQMITLMDKL 719

Human   827 WKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSG 891
            .:...|||::.||..|||..:.|.::.|. |.|:|::.....|:.           |:.::::..
  Fly   720 LRRENLDLKLTPYKVLATSSKHGFLQYVD-SCTVAEVLAREGNIH-----------NFFRKHHPC 772

Human   892 DD-----LDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGI 951
            |:     ....::.:..|||||||.:|:||:||||.||:::...|:|||||||:|||.     ..
  Fly   773 DNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGR-----DP 832

Human   952 KRERVPFILTYDFIHVIQQGKTG--NTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPE 1014
            |....|..|:.:.:..:     |  ::|....||:.|..|||.||||.|:.:.||:||:.|.:|:
  Fly   833 KPMPPPMKLSKEMVEAM-----GGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPD 892

Human  1015 LTSVKD--IQYLKDSLALGKSEEEALKQFKQKFDEAL 1049
            :....|  ::.::::|.||.::|||::..:...|.::
  Fly   893 IALEPDKAVKKVEENLQLGLTDEEAVQHLQSLLDVSI 929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PIK3CBNP_006210.1 PI3K_p85B 41..118 CDD:197539
PI3K_rbd 180..288 CDD:197540
C2_PI3K_class_I_beta_delta 324..501 CDD:176075 46/233 (20%)
Nuclear localization signal 410..418 4/23 (17%)
PI3Ka_I 532..702 CDD:238444 66/305 (22%)
PI3Kc_IA_beta 706..1067 CDD:270717 113/371 (30%)
G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 778..784 1/5 (20%)
Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 916..924 5/7 (71%)
Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 935..961 10/25 (40%)
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 31/148 (21%)
PI3Ka_III 284..561 CDD:238442 64/283 (23%)
PI3Kc_III 601..945 CDD:270628 109/354 (31%)
Blue background indicates that the domain is not in the aligned region.

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