DRSC/TRiP Functional Genomics Resources

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Protein Alignment PIK3CB and pik3

DIOPT Version :10

Sequence 1:NP_006210.1 Gene:PIK3CB / 5291 HGNCID:8976 Length:1070 Species:Homo sapiens
Sequence 2:NP_594699.1 Gene:pik3 / 2543444 PomBaseID:SPAC458.05 Length:801 Species:Schizosaccharomyces pombe


Alignment Length:822 Identity:236/822 - (28%)
Similarity:369/822 - (44%) Gaps:168/822 - (20%)


- Green bases have known domain annotations that are detailed below.


Human   357 LFHGTE---LLCKTIVS---------SEVSGKNDHIWNEPLEFDINICDLPRMARLCFA------ 403
            ||.|.|   |:.|..||         :|:|..:.|.|   |:|.:.:.:|...|:...:      
pombe    40 LFSGNESGSLMQKCFVSKIPNKSLLPTELSKISTHEW---LDFGVTVSELSLNAKFVVSAWKPSF 101

Human   404 ------------VYAVLDK------------VKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTM 444
                        .|.:.|:            ::|.|..|..:|:..:..:        |..:|.:
pombe   102 NDEEVYEFVGCTTYRLFDENNLLRQGLQKIPLQTSKEIKKYSPTSLELEQ--------VKEINRL 158

Human   445 VFDFKG---QLRTGDIILHSW---SSFPDELEEMLNPMGTVQTNP--YTENATALHVKFPENKKQ 501
                .|   :|:.||:...:|   .|| .::::..:...::.|.|  |.:   .|...||...::
pombe   159 ----DGLLLKLQLGDVPSVNWLDDISF-GKIKDFRSKHMSLVTIPILYLD---FLQFSFPVVFQR 215

Human   502 PY--------YYPPFD--KIIEKAAEIASSDSANVSSRGG---------KKFLPVLKEILDRDPL 547
            .|        ||..||  ..::..||:....... |.|.|         .|....|:.||...|.
pombe   216 SYYPKSENRVYYSSFDLELNLDSPAELKHRRLVR-SQRNGPLDKDLKPNSKIRKELESILSYPPS 279

Human   548 SQLCENEMDLIWTLRQDCREIF-----PQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREAL 607
            .:|...|.||||..|      |     .:::.|.|.|:.|....:|.|..:||..|.::...:||
pombe   280 EELSLEEKDLIWKFR------FYLTRNKKAMTKFLKSVVWTDSSEVNQALSLLDSWTEIDIDDAL 338

Human   608 ELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKY-------EPFLDCALSRFLLERAL 665
            |||..::....||.|||..|...|:|||..|||||||.|:|       |.|....|:.||:.||:
pombe   339 ELLSPSFVHPKVRAYAVSRLETASNEELLLYLLQLVQALRYDNPISSDERFQPSPLALFLVNRAI 403

Human   666 GNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNA 730
            .:..||..|:|:|..|:....||..|..::..:       .|.|||.||.....:||::..|...
pombe   404 SSPSIGNDLYWYLVVEIEDEPVSKLFSSVMFLF-------QKELSKSVEGRLIRETLSAQAKFVE 461

Human   731 VKLNRAKGKEAMH-TCLKQSAYREALSD-----------LQSPLNPCVILSELYVEKCKYMDSKM 783
            ..|..:|..::.. |.||:..|.:.|.:           |..||:|.|.:..:..:.|....|.|
pombe   462 KLLRISKSVQSFRGTRLKKIEYLKVLLEDHKYHLLDFHALPLPLDPSVNIVGIIPDACTVFKSTM 526

Human   784 KPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRS 848
            :||.|::  |........:|||||||||||.|.:|:|.|||.|.|:..|||.:.||..||||...
pombe   527 QPLRLLF--KCQDGSKYPIIFKNGDDLRQDQLVIQILTLMDKLLKKEKLDLHLKPYRILATGPTH 589

Human   849 GLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDR--------AIEEFTLSC 905
            |.::.| .|:|:|.|          .|....::|.:|:|.|..|.|:.        |::.:..||
pombe   590 GAVQFV-PSKTLATI----------LAEYHGSVLAYLRENNPDDGLNSANYGIDPVAMDNYVRSC 643

Human   906 AGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGN----FKSKFGIKRERVPFILTYDFIH 966
            |||||.:|:||:||||.||:::.|.|..||.|||:|||.    |.....:.:|.|          
pombe   644 AGYCVITYLLGVGDRHLDNLLITKDGHFFHADFGYILGRDPKLFSPAMKLSKEMV---------- 698

Human   967 VIQQGKTG-NTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD--IQYLKDSL 1028
               :|..| |:..:.:|:..|...:..||:..||.:.||:||:.|.:|::...|:  :..:|:..
pombe   699 ---EGMGGYNSPFYQQFKSYCYTTFTALRKSSNLILNLFSLMVDANIPDIKFDKEKVVYKVKERF 760

Human  1029 ALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS 1070
            .|..||.:|:|.|:|..::::...:...::.| |.:.:..||
pombe   761 CLQMSESDAIKYFEQLINDSVSALFPQIIDRM-HNLAQYMRS 801

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PIK3CBNP_006210.1 PI3K_p85B 41..118 CDD:197539
PI3K_rbd 180..288 CDD:197540
C2_PI3K_class_I_beta_delta 324..501 CDD:176075 37/193 (19%)
Nuclear localization signal 410..418 2/19 (11%)
PI3Ka_I 532..702 CDD:238444 62/181 (34%)
PI3Kc_IA_beta 706..1067 CDD:270717 125/387 (32%)
G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 778..784 1/5 (20%)
Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 916..924 5/7 (71%)
Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269 935..961 10/29 (34%)
pik3NP_594699.1 TEL1 <1..801 CDD:227365 234/820 (29%)
PI3Kc_III 450..797 CDD:270628 119/373 (32%)
Blue background indicates that the domain is not in the aligned region.

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