Protein Alignment PIK3CB and pik3cb

DIOPT Version :10

• Sequence 1: NP_006210.1
• Gene: PIK3CB / 5291
• HGNCID: 8976
• Length: 1070
• Species: Homo sapiens
• Sequence 2: XP_005157523.1
• Gene: pik3cb / 100002263
• ZFINID: ZDB-GENE-030131-1904
• Length: 1080
• Species: Danio rerio
• Alignment Length: 1078
• Identity: 729/1078 - (67%)
• Similarity: 889/1078 - (82%)
• Gaps: 22/1078 - (2%)

Human     7 MPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNYPMFNL 71
            ||||..|.||:|| :|.:..|..:.||||||||||||:|||||:||.:||.:|||:...||:|:|
Zfish     1 MPPAKTDQLDLWA-ESGLDGDDQVMVDFLLPTGIYIQMEVPRESTIQHIKLLLWKEAQTYPLFSL 64

Human    72 LMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEK-LDSKIGVLIGKGLH 135
            |.:::.:||.||||.||:||||||||||||||||||||||:||:|...|: ||||||||||||||
Zfish    65 LGEMEGHMFECVNQAAVHEELEDETRRLCDVRPFLPVLKLITRNCGRAERLLDSKIGVLIGKGLH 129

Human   136 EFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEHEPSIPENLEDKLYGGKLIVA 200
            |.|:|:|.||.:||.||::.||||:..:..:||..||:.:|.|:.:.|..:||.:: :.|.:.:.
Zfish   130 ELDALQDQEVKDFRSKMKRISEEKMQQMQMMSWGQWLRSSYSPQLDTSSLDNLIER-HEGIIKIT 193

Human   201 VHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDEV-SPYDYVLQVSGRVEYVFGDHPLI 264
            :|::..||..|.:||.|....:|.:.|::|..|.||.|::: :..:|||:||.|:|::|.|:|||
Zfish   194 MHYDQSQDTASLKVSLNCTVSEVMDHALKKWQTTHGPEEDIGARSNYVLRVSDRLEFLFEDYPLI 258

Human   265 QFQYIRNCVMNRALPHFILVECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKK---------- 319
            |::|||.|:.....||..:|....:|.|:|:|:..:.:.:.|.:||.||||||||
Zfish   259 QYKYIRACLSTGENPHLTVVHFDIVKSMFEKEIATVGSVLARKTSNPPLPLPPKKRQTTVRTSSM 323

Human   320 ------TRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKND 378
                  .::.:.||:.::.|:|.|||.||:|.|:..|:.|||||||||||||||.||:|.|.:::
Zfish   324 SASQLPQQLHTCVWKVHSLFRINLVKANKVNAEDAAKIQVRAGLFHGTELLCKTAVSNESSSRSE 388

Human   379 HIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNT 443
            |:||:.|||||.:||||||||||||:|||:||||.::|||..:.:||||||||||||||:|||||
Zfish   389 HVWNKTLEFDIPVCDLPRMARLCFAIYAVMDKVKKQRSTKNTHLNKYQTIRKAGKVHYPIAWVNT 453

Human   444 MVFDFKGQLRTGDIILHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPF 508
            ||||::|||:|||||||.||||||||||||||:||:||||||||||.||:.|||...||..:|.|
Zfish   454 MVFDYRGQLKTGDIILHCWSSFPDELEEMLNPIGTIQTNPYTENATELHISFPEYSTQPVVFPAF 518

Human   509 DKIIEKAAEIASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSL 573
            |||:|||||||.:..:....||||||...||||::|||||||||||.|||||||.||||.|||||
Zfish   519 DKILEKAAEIAGASDSMSMGRGGKKFYIELKEIMERDPLSQLCENEKDLIWTLRYDCRENFPQSL 583

Human   574 PKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQY 638
            ||||||:||:|.||:|||||||||||||.||:||||||||||||||||:||.||:.|||:||.||
Zfish   584 PKLLLSVKWSKHEDMAQLQALLQIWPKLSPRDALELLDFNYPDQYVREFAVSCLKDMSDDELLQY 648

Human   639 LLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSV 703
            ||||||||:|||:.||:|||||||||..:|:||.|||||||||:::|||||.|.:||||||||.:
Zfish   649 LLQLVQVLRYEPYYDCSLSRFLLERAQTSRKIGHFLFWHLRSEMYMPAVSVHFALILEAYCRGCI 713

Human   704 GHMKVLSKQVEALNKLKTLNSLIKLNAV--KLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCV 766
            .|::||.||||||||||.:|.||||..:  |..:|..||||.:||:|:.:.|.||||.|||||.:
Zfish   714 PHIEVLKKQVEALNKLKAVNELIKLGTIKTKTKQAHLKEAMMSCLRQTGFIETLSDLHSPLNPNI 778

Human   767 ILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAG 831
            :|:.:.|||||||||||||||:|||||:.|.::||:||||||||||||||||:|:|||||||||.
Zfish   779 LLAGVSVEKCKYMDSKMKPLWIVYNNKLLGGETVGIIFKNGDDLRQDMLTLQILKLMDLLWKEAN 843

Human   832 LDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDR 896
            ||||::|||||||||.||||||||:::|||:||..|||:||||||||||||||||:.||||.||:
Zfish   844 LDLRIVPYGCLATGDHSGLIEVVSSADTIANIQKTSSNMAAAAAFNKDALLNWLKDKNSGDALDK 908

Human   897 AIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILT 961
            |||||||||||||||:|||||||||||||||:.||||||||||||||||||||||||||||||||
Zfish   909 AIEEFTLSCAGYCVATYVLGIGDRHSDNIMVRSTGQLFHIDFGHILGNFKSKFGIKRERVPFILT 973

Human   962 YDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKD 1026
            :|||||||:||||||||||.|||.||:||:|||::||||||||||||||||||||||||||||||
Zfish   974 HDFIHVIQEGKTGNTEKFGNFRQYCEEAYMILRKNGNLFITLFALMLTAGLPELTSVKDIQYLKD 1038

Human  1027 SLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTV 1064
            ||||||::|||||||:||||||||||||||||||||.|
Zfish  1039 SLALGKTDEEALKQFRQKFDEALRESWTTKVNWMAHIV 1076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CB	NP_006210.1	PI3K_p85B	41..118	CDD:197539	53/76 (70%)
		PI3K_rbd	180..288	CDD:197540	38/108 (35%)
		C2_PI3K_class_I_beta_delta	324..501	CDD:176075	125/176 (71%)
		Nuclear localization signal	410..418		4/7 (57%)
		PI3Ka_I	532..702	CDD:238444	134/169 (79%)
		PI3Kc_IA_beta	706..1067	CDD:270717	290/361 (80%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	778..784		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	916..924		7/7 (100%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	935..961		25/25 (100%)
pik3cb	XP_005157523.1	PI3K_p85B	37..109	CDD:460483	49/71 (69%)
		PI3K_rbd	190..281	CDD:413336	34/90 (38%)
		C2_PI3K_class_I_beta_delta	334..511	CDD:176075	125/176 (71%)
		PI3Ka	548..713	CDD:412275	132/164 (80%)
		Protein Kinases, catalytic domain	716..1077	CDD:473864	290/361 (80%)