Protein Alignment PIK3CA and pik3ca

DIOPT Version :10

• Sequence 1: NP_006209.2
• Gene: PIK3CA / 5290
• HGNCID: 8975
• Length: 1068
• Species: Homo sapiens
• Sequence 2: XP_009304452.1
• Gene: pik3ca / 561737
• ZFINID: ZDB-GENE-130409-1
• Length: 1069
• Species: Danio rerio
• Alignment Length: 1069
• Identity: 980/1069 - (91%)
• Similarity: 1027/1069 - (96%)
• Gaps: 1/1069 - (0%)

Human     1 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDE 65
            ||||||||||||||||||||||:||||||||:|||||||||||||||||||||||||||.|||:|
Zfish     1 MPPRPSSGELWGIHLMPPRILVDCLLPNGMILTLECLREATLITIKHELFKEARKYPLHHLLQEE 65

Human    66 SSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDM 130
            :||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||||:
Zfish    66 TSYIFVSVTQEAEREEFYDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDL 130

Human   131 VKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIW 195
            ||||||||||||||||||::|:|||.:..||||:||||||||||||||||||.||||||||||||
Zfish   131 VKDPEVQDFRRNILNVCKDSVELRDASGAHSRALYVYPPNVESSPELPKHIYGKLDKGQIIVVIW 195

Human   196 VIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEY 260
            ||||||||||||||||||||||||||||||||||||||||:||||:||.||||||||||||||||
Zfish   196 VIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSAEQLKMCVQEYQGKYILKVCGCDEY 260

Human   261 FLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTK 325
            .|||||:|||||:||||||||:||||||:|:|||||||||.||||||||||||||||||||.|||
Zfish   261 LLEKYPISQYKYVRSCIMLGRLPNLMLMSKDSLYSQLPMDNFTMPSYSRRISTATPYMNGEASTK 325

Human   326 SLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYD 390
            |||.|||.|||::|||||||||||||||||||||||||||.|||||||||||||||||||||.||
Zfish   326 SLWTINSTLRIRVLCATYVNVNIRDIDKIYVRTGIYHGGEQLCDNVNTQRVPCSNPRWNEWLTYD 390

Human   391 IYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDL 455
            :||||:||||||||||||||||||||||||||||||:||||||.|||||||||||||||||||||
Zfish   391 MYIPDIPRAARLCLSICSVKGRKGAKEEHCPLAWGNVNLFDYTHTLVSGKMALNLWPVPHGLEDL 455

Human   456 LNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARD 520
            |||||||||||||||||||||||:|||.||||||:.||:||||.:|||.|::|..:|.|:|:|||
Zfish   456 LNPIGVTGSNPNKETPCLELEFDYFSSPVKFPDMATIEDHANWIISREMGYNYCQSGQSSRVARD 520

Human   521 NELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYC 585
            :.:.|.|.|||:.:..||||||||||||||||.||.|||.|||||||:||:||||||||||||||
Zfish   521 HAMTEADIEQLRQLGNRDPLSEITEQEKDFLWRHRQYCVNIPEILPKILLAVKWNSRDEVAQMYC 585

Human   586 LVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLV 650
            |:||||.||||||||||||||||||:|.||||||||||||||||||||||||||||||||||.||
Zfish   586 LLKDWPAIKPEQAMELLDCNYPDPMIRDFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNPLV 650

Human   651 RFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINL 715
            ||||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||
Zfish   651 RFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSRQVEAMEKLINL 715

Human   716 TDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW 780
            ||||||||||||||||||||||||||||:|||||.|.|||||||||||||||:||||||||||||
Zfish   716 TDILKQEKKDETQKVQMKFLVEQMRRPDYMDALQNFTSPLNPAHQLGNLRLEDCRIMSSAKRPLW 780

Human   781 LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCV 845
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   781 LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCV 845

Human   846 GLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFI 910
            |||||||:|||||||||||||||||||||.|||||||||||||:||.||||||||||||||||||
Zfish   846 GLIEVVRSSHTIMQIQCKGGLKGALQFNSTTLHQWLKDKNKGEMYDMAIDLFTRSCAGYCVATFI 910

Human   911 LGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISK-GAQECTKT 974
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||| |.||||||
Zfish   911 LGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGGTQECTKT 975

Human   975 REFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYF 1039
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
Zfish   976 REFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALDYF 1040

Human  1040 MKQMNDAHHGGWTTKMDWIFHTIKQHALN 1068
            |||||||||||||||||||||||:.||.|
Zfish  1041 MKQMNDAHHGGWTTKMDWIFHTIRHHAQN 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CA	NP_006209.2	PI3K_p85B	31..108	CDD:197539	71/76 (93%)
		PI3K_rbd	173..292	CDD:197540	109/118 (92%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	147/158 (93%)
		PI3Ka_I	525..696	CDD:238444	153/170 (90%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	357/369 (97%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	771..777		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	912..920		7/7 (100%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	931..957		25/25 (100%)
pik3ca	XP_009304452.1	PI3K_p85B	34..107	CDD:460483	68/72 (94%)
		PI3K_rbd	173..292	CDD:413336	109/118 (92%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	147/158 (93%)
		PI3Ka_I	529..696	CDD:238444	151/166 (91%)
		Protein Kinases, catalytic domain	695..1065	CDD:473864	357/369 (97%)