Protein Alignment PIK3CA and Pi3K92E

DIOPT Version :9

• Sequence 1: NP_006209.2
• Gene: PIK3CA / 5290
• HGNCID: 8975
• Length: 1068
• Species: Homo sapiens
• Sequence 2: NP_001262770.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 1122
• Identity: 391/1122 - (34%)
• Similarity: 611/1122 - (54%)
• Gaps: 115/1122 - (10%)

Human     2 PPRPS-------SGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLH 59
            ||..:       |..||...::....|: ||||||.::.|......|:..||.|:..:|::.||.
  Fly    21 PPEEAEPPCMRFSVNLWKNEMLNWVDLI-CLLPNGFLLELRVNPANTIQVIKVEMVNQAKQMPLG 84

Human    60 QLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREE-----------KIL 113
            .::::...|....:: ....|.:.|||:||.::   ||:..::. :|.|.:           |::
  Fly    85 YVIKEACEYQVYGIS-TFNIEPYTDETKRLSEV---QPYFGILS-LGERTDTTSFSSDYELTKMV 144

Human   114 NREIGFAIGMPVCEFDMVK---DPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSP 175
            |..||       ..||..:   .||:.|||..:...|......|...:...|.:|.:|..:.:|.
  Fly   145 NGMIG-------TTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYEHPLRLANST 202

Human   176 ELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK 240
            ::|:.|..:......::|    |...||:..:||.:|....|..:....::|..||.:..:::
  Fly   203 KMPELIRERHPTRTFLIV----VKNENDQSTFTLSVNEQDTPFSLTESTLQKMNRSQMKMNDR-- 261

Human   241 LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMP 305
                  ...|||||.|.|||.|..|||.|:.||:..:....:||::|   :|:|.   ::.:...
  Fly   262 ------TSDYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPNVVL---QSVYR---LESYINH 314

Human   306 SYSRRISTATPYMNGET-----STKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGE 365
            ...:.:.|..|.....|     |..|||.:.:..::.:...:.||.:.....|:.|...:|||.:
  Fly   315 HNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCLYHGDK 379

Human   366 PLCDNVNTQRVPCSNPRWNEWL------NYDIYIPDLPRAARLCLSICSV----KGRKGAKEEHC 420
            .||...:|.   ..|..::.:|      ::||.:.:|||..|||:.|..|    :.:|.:..:..
  Fly   380 KLCAQRSTD---SPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDI 441

Human   421 ----------PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLE--DLLNPIGVTGSNPNKETPCL 473
                      ||||.|..:||:.|.|.:|:..|..|.....::  ::.:|:|....||.|| .|.
  Fly   442 ALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKE-ECA 505

Human   474 ELEFDWFSS---VVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAIS 535
            .::..:.||   .|::|...|:.::|   ..||.         .|||.|.....|...::||.:.
  Fly   506 LVDLTFLSSGTGTVRYPSEEVVLQYA---ADREQ---------VNRLQRQLAGPEKPIKELKELM 558

Human   536 TR----DPLSEITEQEKDFLWSHRHYCV-TIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKP 595
            ..    |.:.|:.:|:::.:|..|:..: .:||.|..||..|.|..||:||.|:.|:|.||.|..
  Fly   559 ANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISI 623

Human   596 EQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN 660
            |:::||||..||||.||.||:|||. :|.|:.|..||:||||.:|:|.||::.||.|||::||.|
  Fly   624 ERSLELLDYAYPDPAVRRFAIRCLH-FLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRN 687

Human   661 QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKD 725
            |||||:|||||:|||...::..|||||||.|.:.|..::..|.:|:..:|||...:.|.|:..|:
  Fly   688 QRIGHYFFWHLRSEMQTPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKE 752

Human   726 ETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMS 790
            :.:.:...||.:|.....|    |...:||||:.:...:..:.|::|.|..||||:.:||.|:.:
  Fly   753 KVKTMLQDFLRDQRNSAVF----QNIQNPLNPSFRCSGVTPDRCKVMDSKMRPLWVVFENADVNA 813

Human   791 ELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSH 855
                .:..|||||||||||||||||::|:|:.:|:..|:|.||..|.|:|:...:|:|||||::.
  Fly   814 ----SDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAE 874

Human   856 TIMQIQCKGGLKGALQ-FNSHTLHQWLKDKNK-GEIYDAAIDLFTRSCAGYCVATFILGIGDRHN 918
            ||..||.:.|:..|.. |...:|..|||:.|| .:..:.||:.||.|||||||||::||:.|||:
  Fly   875 TIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCAGYCVATYVLGVADRHS 939

Human   919 SNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEM 983
            .|||||.:||||||||||.|.|.|:|.|.:|||||||||.||:.||:||..: .:::||..|||:
  Fly   940 DNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFND-RESKEFCHFQEL 1003

Human   984 CYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHH 1048
            |.:|:|.:|:|..|.::|||||:.:|:|||.|..|:.|:|:||.||.||::|.|:|..:.::|..
  Fly  1004 CERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALA 1068

Human  1049 GGWTTKMDWIFHTIKQH 1065
            ..|.|.::|..|...::
  Fly  1069 NSWKTSLNWASHNFSKN 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CA	NP_006209.2	PI3K_p85B	32..107	CDD:396665	17/74 (23%)
		PI3K_rbd	173..292	CDD:197540	33/118 (28%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	47/183 (26%)
		PI3Ka_I	525..696	CDD:238444	83/175 (47%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	165/370 (45%)
Pi3K92E	NP_001262770.1	PI3K_p85B	56..132	CDD:295322	19/80 (24%)
		PI3K_rbd	200..307	CDD:197540	34/121 (28%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	47/181 (26%)
		PI3Ka_I	552..723	CDD:238444	82/171 (48%)
		PI3Kc_I	727..1084	CDD:270709	164/365 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D204282at2759
OrthoFinder	1	1.000	-	-		FOG0001201
OrthoInspector	1	1.000	-	-		otm42149
orthoMCL	1	0.900	-	-		OOG6_100986
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5021
SonicParanoid	1	1.000	-	-		X531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.750