Protein Alignment PIK3CA and pik3

DIOPT Version :9

• Sequence 1: NP_006209.2
• Gene: PIK3CA / 5290
• HGNCID: 8975
• Length: 1068
• Species: Homo sapiens
• Sequence 2: NP_594699.1
• Gene: pik3 / 2543444
• PomBaseID: SPAC458.05
• Length: 801
• Species: Schizosaccharomyces pombe
• Alignment Length: 770
• Identity: 206/770 - (26%)
• Similarity: 351/770 - (45%)
• Gaps: 170/770 - (22%)

Human   384 NEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSG--------- 439
            :|||::.:.:.:|...|:..:|  :.|.....:|.:..:......|||..:.|..|
pombe    74 HEWLDFGVTVSELSLNAKFVVS--AWKPSFNDEEVYEFVGCTTYRLFDENNLLRQGLQKIPLQTS 136

Human   440 ---------------------------KMALNLWPVPHGLEDLLNPIGVTGSNPNKE-----TPC 472
                                       |:.|...|..:.|:|:  ..|......:|.     .|.
pombe   137 KEIKKYSPTSLELEQVKEINRLDGLLLKLQLGDVPSVNWLDDI--SFGKIKDFRSKHMSLVTIPI 199

Human   473 LELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLS-----------NRLAR------- 519
            |.|:|..||    ||   |:.:.:.:..|....: ||...|.           .||.|
pombe   200 LYLDFLQFS----FP---VVFQRSYYPKSENRVY-YSSFDLELNLDSPAELKHRRLVRSQRNGPL 256

Human   520 DNELRENDK--EQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQ 582
            |.:|:.|.|  ::|::|.:..|..|::.:|||.:|..|.|.....:.:.|.|.||.|....||.|
pombe   257 DKDLKPNSKIRKELESILSYPPSEELSLEEKDLIWKFRFYLTRNKKAMTKFLKSVVWTDSSEVNQ 321

Human   583 MYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKY------ 641
            ...|:..|..|..:.|:|||..::..|.||.:||..||. .::::|..||:||||.|:|
pombe   322 ALSLLDSWTEIDIDDALELLSPSFVHPKVRAYAVSRLET-ASNEELLLYLLQLVQALRYDNPISS 385

Human   642 -EQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQ 705
             |::..:.|..||:.:|:::..||:..:|:|..|:.::.||:.|..::       .::.|.|::.
pombe   386 DERFQPSPLALFLVNRAISSPSIGNDLYWYLVVEIEDEPVSKLFSSVM-------FLFQKELSKS 443

Human   706 VEA-------------MEKLINLTDILKQEKKDETQKVQ-MKFLVEQMRRPDFMDALQGFLSPLN 756
            ||.             :|||:.::..::..:....:|:: :|.|:|. .:...:| ......||:
pombe   444 VEGRLIRETLSAQAKFVEKLLRISKSVQSFRGTRLKKIEYLKVLLED-HKYHLLD-FHALPLPLD 506

Human   757 PAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNE-----IIFKNGDDLRQDMLTLQI 816
            |:..:..:..:.|.:..|..:||           .|||:..:     ||||||||||||.|.:||
pombe   507 PSVNIVGIIPDACTVFKSTMQPL-----------RLLFKCQDGSKYPIIFKNGDDLRQDQLVIQI 560

Human   817 IRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQI--QCKGGLKGALQFNSHTLHQ 879
            :.:|:.:.:.:.|||.:.||..|:.|...|.::.| .|.|:..|  :..|.:...|:.|:.  ..
pombe   561 LTLMDKLLKKEKLDLHLKPYRILATGPTHGAVQFV-PSKTLATILAEYHGSVLAYLRENNP--DD 622

Human   880 WLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKK 944
            .|...|.| |...|:|.:.||||||||.|::||:||||..|:::..||..||.|||:.|....|.
pombe   623 GLNSANYG-IDPVAMDNYVRSCAGYCVITYLLGVGDRHLDNLLITKDGHFFHADFGYILGRDPKL 686

Human   945 F---------------GYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQH 994
            |               ||..   ||                      :::|:..||..:.|:|:.
pombe   687 FSPAMKLSKEMVEGMGGYNS---PF----------------------YQQFKSYCYTTFTALRKS 726

Human   995 ANLFINLFSMMLGSGMPELQSFD--DIAY-IRKTLALDKTEQEALEYFMKQMNDA 1046
            :||.:||||:|:.:.:|::: ||  .:.| :::...|..:|.:|::||.:.:||:
pombe   727 SNLILNLFSLMVDANIPDIK-FDKEKVVYKVKERFCLQMSESDAIKYFEQLINDS 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CA	NP_006209.2	PI3K_p85B	32..107	CDD:396665
		PI3K_rbd	173..292	CDD:197540
		C2_PI3K_class_I_alpha	325..484	CDD:176043	26/140 (19%)
		PI3Ka_I	525..696	CDD:238444	56/179 (31%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	112/391 (29%)
pik3	NP_594699.1	TEL1	<1..801	CDD:227365	206/770 (27%)
		C2	30..181	CDD:301316	18/110 (16%)
		PI3Ka_III	257..422	CDD:238442	55/165 (33%)
		PI3Kc_III	450..797	CDD:270628	108/374 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810