Protein Alignment PIK3CA and Pik3ca

DIOPT Version :10

• Sequence 1: NP_006209.2
• Gene: PIK3CA / 5290
• HGNCID: 8975
• Length: 1068
• Species: Homo sapiens
• Sequence 2: NP_032865.2
• Gene: Pik3ca / 18706
• MGIID: 1206581
• Length: 1068
• Species: Mus musculus
• Alignment Length: 1068
• Identity: 1054/1068 - (98%)
• Similarity: 1061/1068 - (99%)
• Gaps: 0/1068 - (0%)

Human     1 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDE 65
            ||||||||||||||||||||||||||||||||||||||||||:|||||||:||||||||||||||
Mouse     1 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFREARKYPLHQLLQDE 65

Human    66 SSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDM 130
            :|||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||
Mouse    66 TSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFVIGMPVCEFDM 130

Human   131 VKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIW 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 VKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIW 195

Human   196 VIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEY 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 VIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEY 260

Human   261 FLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTK 325
            ||||||||||||||||||||||||||||||||||||||:|.||||||||||||||||||||||||
Mouse   261 FLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPIDSFTMPSYSRRISTATPYMNGETSTK 325

Human   326 SLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYD 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 SLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYD 390

Human   391 IYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDL 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 IYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDL 455

Human   456 LNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARD 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
Mouse   456 LNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARD 520

Human   521 NELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYC 585
            |||||||||||:|:.||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 NELRENDKEQLRALCTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYC 585

Human   586 LVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLV 650
            |||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
Mouse   586 LVKDWPPIKPEQAMELLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLV 650

Human   651 RFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINL 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 RFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINL 715

Human   716 TDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW 780
            |||||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||
Mouse   716 TDILKQEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW 780

Human   781 LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCV 845
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   781 LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCV 845

Human   846 GLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFI 910
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   846 GLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFI 910

Human   911 LGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTR 975
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
Mouse   911 LGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQEYTKTR 975

Human   976 EFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFM 1040
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.
Mouse   976 EFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFT 1040

Human  1041 KQMNDAHHGGWTTKMDWIFHTIKQHALN 1068
            ||||||||||||||||||||||||||||
Mouse  1041 KQMNDAHHGGWTTKMDWIFHTIKQHALN 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CA	NP_006209.2	PI3K_p85B	31..108	CDD:197539	73/76 (96%)
		PI3K_rbd	173..292	CDD:197540	118/118 (100%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	158/158 (100%)
		PI3Ka_I	525..696	CDD:238444	166/170 (98%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	365/368 (99%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	771..777		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	912..920		7/7 (100%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	931..957		25/25 (100%)
Pik3ca	NP_032865.2	PI3K_p85B	31..108	CDD:197539	73/76 (96%)
		PI3K_rbd	173..292	CDD:197540	118/118 (100%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	158/158 (100%)
		PI3Ka_I	525..696	CDD:238444	166/170 (98%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	365/368 (99%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	771..777		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	912..920		7/7 (100%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	931..957		25/25 (100%)