Protein Alignment PIK3CA and pik3ca

DIOPT Version :10

• Sequence 1: NP_006209.2
• Gene: PIK3CA / 5290
• HGNCID: 8975
• Length: 1068
• Species: Homo sapiens
• Sequence 2: NP_001119972.1
• Gene: pik3ca / 100144924
• XenbaseID: XB-GENE-998106
• Length: 1065
• Species: Xenopus tropicalis
• Alignment Length: 1063
• Identity: 976/1063 - (91%)
• Similarity: 1018/1063 - (95%)
• Gaps: 0/1063 - (0%)

Human     1 MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDE 65
            ||||||||||||||||||||||||||||||:|.|||||||||:.||||||||||||||:.|||||
 Frog     1 MPPRPSSGELWGIHLMPPRILVECLLPNGMVVVLECLREATLVNIKHELFKEARKYPLYHLLQDE 65

Human    66 SSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDM 130
            ||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||
 Frog    66 SSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVVEPVGNREEKILNREIGFAIGMPVCEFDM 130

Human   131 VKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIW 195
            |||.||||||:|||||||::|:|||.|.|.|||:||||||||||.||||||.:||||||||||||
 Frog   131 VKDSEVQDFRKNILNVCKDSVELRDANGPISRALYVYPPNVESSSELPKHIESKLDKGQIIVVIW 195

Human   196 VIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEY 260
            |||||||:||||:||||||||||.|||||||||||||||||||||||||||||||||||||||||
 Frog   196 VIVSPNNEKQKYSLKINHDCVPEHVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEY 260

Human   261 FLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTK 325
            .|||||||||||||||||||||||||||||:|||||:|:|.|||||||||||||.||||||.|.|
 Frog   261 LLEKYPLSQYKYIRSCIMLGRMPNLMLMAKDSLYSQIPVDVFTMPSYSRRISTAAPYMNGEASAK 325

Human   326 SLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYD 390
            |||.|||.||||||||||||||||||||||||||||||.|||||||||||||||||||||||.||
 Frog   326 SLWAINSTLRIKILCATYVNVNIRDIDKIYVRTGIYHGVEPLCDNVNTQRVPCSNPRWNEWLLYD 390

Human   391 IYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDL 455
            ::|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   391 MFIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDL 455

Human   456 LNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARD 520
            ||||||:||||||||||||||||.|||.||||||:.||:|||..:.||.|::|||:|||||:.|:
 Frog   456 LNPIGVSGSNPNKETPCLELEFDCFSSPVKFPDMTAIEDHANKVLEREMGYNYSHSGLSNRIVRE 520

Human   521 NELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYC 585
            ||:||:|||||||||.||||||||||||:||||||.||..|||||||||||||||.||:|:||||
 Frog   521 NEVRESDKEQLKAISNRDPLSEITEQEKEFLWSHRLYCRNIPEILPKLLLSVKWNCRDDVSQMYC 585

Human   586 LVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLV 650
            |:|:||.|:|||||||||.||||.:||.|||.|||||||||||||||||||||:||||||||.||
 Frog   586 LLKEWPAIRPEQAMELLDFNYPDRIVRSFAVSCLEKYLTDDKLSQYLIQLVQVMKYEQYLDNHLV 650

Human   651 RFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINL 715
            ||||||||.||||||||||.||||||||||||||||||||||||||||||||::|||||||||||
 Frog   651 RFLLKKALVNQRIGHFFFWLLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLSKQVEAMEKLINL 715

Human   716 TDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW 780
            ||||||||||||||||||||||||:|||||||||||.||||||||||||||||||||||||||||
 Frog   716 TDILKQEKKDETQKVQMKFLVEQMKRPDFMDALQGFTSPLNPAHQLGNLRLEECRIMSSAKRPLW 780

Human   781 LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCV 845
            |||||||||||:||.||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   781 LNWENPDIMSEMLFLNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCV 845

Human   846 GLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFI 910
            |||||||.|||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
 Frog   846 GLIEVVRCSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGETYDAAIDLFTRSCAGYCVATFI 910

Human   911 LGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTR 975
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||.|||||||
 Frog   911 LGIGDRHNSNIMVKDNGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGIQECTKTR 975

Human   976 EFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFM 1040
            :||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   976 DFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFM 1040

Human  1041 KQMNDAHHGGWTTKMDWIFHTIK 1063
            |||||||||||||||||||||||
 Frog  1041 KQMNDAHHGGWTTKMDWIFHTIK 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3CA	NP_006209.2	PI3K_p85B	31..108	CDD:197539	69/76 (91%)
		PI3K_rbd	173..292	CDD:197540	111/118 (94%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	150/158 (95%)
		PI3Ka_I	525..696	CDD:238444	148/170 (87%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	358/369 (97%)
		G-loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	771..777		5/5 (100%)
		Catalytic loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	912..920		7/7 (100%)
		Activation loop. /evidence=ECO:0000255|PROSITE-ProRule:PRU00269	931..957		25/25 (100%)
pik3ca	NP_001119972.1	PI3K_p85B	34..107	CDD:460483	67/72 (93%)
		PI3K_rbd	173..292	CDD:413336	111/118 (94%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	150/158 (95%)
		PI3Ka_I	525..696	CDD:238444	148/170 (87%)
		Protein Kinases, catalytic domain	695..1064	CDD:473864	358/369 (97%)