DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PIK3C3 and Pi3K59F

DIOPT Version :9

Sequence 1:NP_002638.2 Gene:PIK3C3 / 5289 HGNCID:8974 Length:887 Species:Homo sapiens
Sequence 2:NP_477133.1 Gene:Pi3K59F / 37733 FlyBaseID:FBgn0015277 Length:949 Species:Drosophila melanogaster


Alignment Length:951 Identity:523/951 - (54%)
Similarity:670/951 - (70%) Gaps:75/951 - (7%)


- Green bases have known domain annotations that are detailed below.


Human     5 EKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKP 69
            :.|.||:|..|...||:|:|:||||:.|..|:.:||||:|:|||||.|......|..|||.:|:|
  Fly     6 DHFRYIHSSSLHERVQIKVGTLEGKKRQPDYEKLLEDPILRFSGLYSEEHPSFQVRLQVFNQGRP 70

Human    70 LALPVRTSYKAFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGKAVPVGGTTVSLFGKYG 134
            ..|||.:|||||..||:||||:.||:::.||||:|.:.|||.|..|.|:...:|||::|:|||.|
  Fly    71 YCLPVTSSYKAFGKRWSWNEWVTLPLQFSDLPRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDG 135

Human   135 MFRQGMHDLKVWPNVEADGSEPTKTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFR 199
            ||||||:||:||..||.||:.|::|||:...: |:.||.||.||.|.||.|.:.|||||||||||
  Fly   136 MFRQGMYDLRVWLGVEGDGNFPSRTPGKGKES-SKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFR 199

Human   200 EIEMINESEKRSSNFMYLMVEFRCVKCDDK-EYGIVYYEKDGDESSPILTSFELVKVPDPQMSME 263
            |||:|||.|||.|::|:||:||..:..||. .|.:||:|.:||....:....:||.|||.::.||
  Fly   200 EIEVINEREKRMSDYMFLMIEFPAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQME 264

Human   264 NLVESKHHKLARSLRSGPSDHDLKPNAATRDQLNIIV-SYPPTKQLTYEEQDLVWKFRYYLTNQE 327
            ||||.|||:||||.|||.||.|.||.|:.||||:.|| .||||..|:.||||||||||:||::.:
  Fly   265 NLVERKHHRLARSERSGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHK 329

Human   328 KALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDL 392
            |||||||||:||.|..|..|||.:|..|.||||||:|||||..:|:|.||:|||:||.||.||||
  Fly   330 KALTKFLKCINWKLEDEVTQALWMLANWAPMDVEDALELLSPTFTHPQVRKYAVSRLAQAPDEDL 394

Human   393 LMYLLQLVQALKYEN---------------------FDDIKNGLEPTKKDSQSSVSE-NVSNSGI 435
            |:||||||||||||:                     .||..:.|:      |||:|: :.::||:
  Fly   395 LLYLLQLVQALKYEDPRHIVHLHGCIFPERDVVRSILDDNGSLLD------QSSLSDLSATSSGL 453

Human   436 NSAEIDSSQIITS---------------------------PLPSVSSP-PPASKTKEVPDGEN-- 470
            :.:.|.::|...|                           .||:.|:| .|.|.:.......|  
  Fly   454 HGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALPNPSAPATPGSSSLPCDSNSNAL 518

Human   471 ----------LEQDLCTFLISRACKNSTLANYLYWYVIVECED-QDTQQRDPKTHEMYLNVMRRF 524
                      :..:||||||.|||.|:|||||.|||:.:|.|: :..:::|.:.|:||..|::.|
  Fly   519 MLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEVESVRKQDERAHDMYAMVLKMF 583

Human   525 SQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNE--KMNLSD 587
            .:.|..|:.::|.:...|..|:.|:|.||.|:|.|.:|.|||.||.|:.|.||.:.:  |:|.::
  Fly   584 LKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNKKTEKFQKLLAEQDMFKVNFTN 648

Human   588 VELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDG-GKYPVIFKHGDDLRQDQLILQII 651
            .|.||.||:|::.|..|:|...:|||||||||:|.|.|... .:|..||||||||||||||||:|
  Fly   649 FEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHEYAAIFKHGDDLRQDQLILQMI 713

Human   652 SLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSENGPNG 716
            :|||||||:||||||||||||||||:||||:|::.|..|||||..||:|.|||||:.|.:|||.|
  Fly   714 TLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLAREGNIHNFFRKHHPCDNGPYG 778

Human   717 ISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNK 781
            |||||||||:|||||||||||:||||||||||||||..||||||||||||||||||:||||||:|
  Fly   779 ISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLFHIDFGYILGRDPKPMPPPMKLSK 843

Human   782 EMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKF 846
            ||||.|||..||.:.|||||||||:|||||::|::||||||||||.:|||||||||.||||::..
  Fly   844 EMVEAMGGISSEHHHEFRKQCYTAYLHLRRHANVMLNLFSLMVDATVPDIALEPDKAVKKVEENL 908

Human   847 RLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK 887
            :|.|:|||||.::|||:|.|:.|:..|:|||||:|.|||||
  Fly   909 QLGLTDEEAVQHLQSLLDVSITAVMPALVEQIHRFTQYWRK 949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PIK3C3NP_002638.2 C2_PI3K_class_III 26..186 CDD:176042 86/159 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 149..170 9/20 (45%)
PI3Ka_III 283..503 CDD:238442 123/282 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 447..467 7/47 (15%)
PI3Kc_III 539..883 CDD:270628 233/346 (67%)
Pi3K59FNP_477133.1 C2_PI3K_class_III 27..186 CDD:176042 86/159 (54%)
PI3Ka_III 284..561 CDD:238442 123/282 (44%)
PI3Kc_III 601..945 CDD:270628 233/343 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159501
Domainoid 1 1.000 234 1.000 Domainoid score I2398
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1986
Inparanoid 1 1.050 1007 1.000 Inparanoid score I291
Isobase 1 0.950 - 0 Normalized mean entropy S1375
OMA 1 1.010 - - QHG54334
OrthoDB 1 1.010 - - D204282at2759
OrthoFinder 1 1.000 - - FOG0005021
OrthoInspector 1 1.000 - - oto91755
orthoMCL 1 0.900 - - OOG6_101850
Panther 1 1.100 - - LDO PTHR10048
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1651
SonicParanoid 1 1.000 - - X3549
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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